A5101765621- Neural Networks and Applications
- Control Systems and Identification
- Risk and Portfolio Optimization
- Advanced Vision and Imaging
- Model Reduction and Neural Networks
- Image and Signal Denoising Methods
- Advanced Bandit Algorithms Research
- Advanced Measurement and Detection Methods
- Matrix Theory and Algorithms
- Blind Source Separation Techniques
- Advanced Algorithms and Applications
- RNA modifications and cancer
- Full-Duplex Wireless Communications
- Cooperative Communication and Network Coding
- Face and Expression Recognition
- Wireless Communication Security Techniques
- Machine Learning and ELM
- Speech and Audio Processing
- Traffic control and management
- Cancer-related molecular mechanisms research
- Advanced Numerical Analysis Techniques
- Higher Education and Teaching Methods
- Multi-Criteria Decision Making
- Advanced Optimization Algorithms Research
- Video Surveillance and Tracking Methods
Air Force Medical University
2018-2025
East China Normal University
2025
Central South University
2022-2024
Chongqing University
2023
Tsinghua University
2008-2022
Ningbo University
2022
Qingdao University
2021
Qingdao Mental Health Center
2021
University of Waterloo
2013
Pingdingshan University
2012
CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, underlying mechanisms remain challenging to fully investigate. Here, we used Genome-wide CRISPR/Cas9 library screening combined with single-cell sequencing screen molecules mediating identified METTL14 as determinant of sensitivity. Clinical samples datasets were analyzed in vitro vivo experiments performed...
Despite the outstanding clinical success of immunotherapy, its therapeutic efficacy in glioblastoma (GBM) is still limited. To identify critical regulators GBM immunity, we constructed a mouse single-guide RNA (sgRNA) library corresponding to all disease-related immune genes, and performed an vivo CRISPR knockout (KO) screen syngeneic models. We demonstrated that deletion GDF15 cells ameliorated immunosuppressive tumor microenvironment (TME) enhanced antitumor checkpoint blockade (ICB)...
Out-of-distribution (OOD) generalization in Graph Neural Networks (GNNs) has gained significant attention due to its critical importance graph-based predictions real-world scenarios. Existing methods primarily focus on extracting a single causal subgraph from the input graph achieve generalizable predictions. However, relying can lead susceptibility spurious correlations and is insufficient for learning invariant patterns behind data. Moreover, many applications, such as molecular property...
Facial expression recognition (FER) is a crucial task for human-computer interaction and multitude of multimedia applications that typically call friendly, unobtrusive, ubiquitous, even long-term monitoring. Achieving such FER system meeting these multi-requirements faces critical challenges, mainly including the tiny irregular non-periodic deformation emotion movements, high variability in facial positions severe self-interference caused by users' own other behavior. In this work, we...
The problem of constructing a general continuous piecewise-linear neural network is considered in this paper. It shown that every projection domain an arbitrary function can be partitioned into convex polyhedra by using difference functions its local linear functions. Based on these polyhedra, group basis are formulated. proven combination plus constant, which we call standard network, represent all In addition, the proposed applied to solve some approximation problems. A number numerical...
Abstract FOXP3 is an important X-linked suppressor of breast cancer. It reported that usually mutant, absent, or cytoplasmic distribution in cancer cells, which increases the risk However, our study full-length transcript can be detected cells and nuclear expressed some samples. Therefore, question how tumor-suppressive function wild-type negated these cancers. We found Gal-1 a novel interacting protein Furthermore, results show FKH domain essential for its interaction with Gal-1. Through...
This brief proposes a truncated ℓ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> distance (TL1) kernel, which results in classifier that is nonlinear the global region but linear each subregion. With this subregion structure can be trained using all training data and local classifiers established simultaneously. The TL1 kernel has good adaptiveness to nonlinearity suitable for problems require different nonlinearities areas. Though not...
Tendon injury is a common but tough medical problem. Unsatisfactory clinical results have been reported in tendon repair using mesenchymal stem cell (MSC) therapy, creating need for better strategy to induce MSCs tenogenic differentiation. This study was designed examine the effect of hypoxia on differentiation different and their capacities under condition vitro investigate vivo inductility tenogenesis. Adipose tissue-derived (AMSCs) bone marrow-derived (BMSCs) were isolated characterized....
Silent Speech Interface (SSI) has been proposed as a means of reconstructing audible speech from silent articulatory gestures for covert voice communication in public and assistance the aphasic. Prior arts SSI, either relying on wearable devices or cameras, may lead to extended contact requirements privacy leakage risks. The recent advances acoustic sensing have brought new opportunities gestures, but their original intention is infer content classification instead reconstruction, resulting...
Although metabolic disorders and smoking are common in schizophrenia, few studies have investigated the effects of on or syndrome (MetS) schizophrenia patients, especially first-episode drug-naïve (FEDN) patients. We sought to investigate differences MetS between nonsmoking FEDN patients.A total 428 patients 435 controls were recruited. Blood pressure, waist circumference, body mass index (BMI), lipid profiles, glucose metabolism measured. The psychopathology was evaluated by Positive...
The recently reported inhibitory effects of angiotensin 1–7 (Ang-(1–7)) on various cancers indicate its potential use as a therapeutic agent for primary and metastatic cancers. However, extremely short half-life in the circulation greatly compromises applications. Here, we an Ang-(1–7) analogue peptide with amino carboxy termini protected by acetylation amination. vitro vivo degradation resulting analogue, Ang-AA, were determined using high-performance liquid chromatography (HPLC). At same...
A novel f-f model is developed constructively which can express any n-dimensional piecewise linear (PWL) function by a superposition of basis functions if it defined over an nth-order degenerate intersection formed (n-1)th-order minimal intersections. We also propose the concrete functional forms functions. Being simplest type intersection, most elementary "building block" PWL in arbitrary-dimensional space. In addition, constitutes natural continuation to Julian's canonical formulation and...
The adaptive hinging hyperplane (AHH) model is a popular piecewise linear representation with generalized tree structure and has been successfully applied in dynamic system identification. In this article, we aim to construct the deep AHH (DAHH) extend generalize networking of for high-dimensional problems. network DAHH determined through forward growth, which activity ratio introduced select effective neurons no connecting weights are involved between layers. Then, all can be flexibly...
In the last four decades, many efforts have been made to improve factors of safety and comfort in area vehicular traffic. future intelligent transportation systems, one important aspect automation components is design control systems that enables system behave autonomously, thus ensuring safety, best usage available infrastructure. this paper, two separate strategies are adopted for a longitudinal vehicle model. A third-order linear models power train dynamics. Based on theory optimal by QR...