A5037119494- Spine and Intervertebral Disc Pathology
- Macrophage Migration Inhibitory Factor
- Whipple's Disease and Interleukins
- TGF-β signaling in diseases
- Extracellular vesicles in disease
- Connective tissue disorders research
- S100 Proteins and Annexins
- Cervical and Thoracic Myelopathy
- Tuberculosis Research and Epidemiology
Southern Medical University
2021-2024
Nanfang Hospital
2024
First Affiliated Hospital of Kunming Medical University
2019
Kunming Medical University
2019
Abstract Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates bone healing, but the underlying mechanism is unclear. This study shows after TBI, injured neurons, mainly those in hippocampus, release osteogenic microRNA (miRNA)-enriched small extracellular vesicles (sEVs), which targeted osteoprogenitors to stimulate formation. We show miR-328a-3p and miR-150-5p, enriched sEVs promote osteogenesis by directly targeting 3′UTR of FOXO4 or CBL ,...
Lumbar spinal canal stenosis is primarily caused by ligamentum flavum hypertrophy (LFH), which a significant pathological factor. Nevertheless, the precise molecular basis for development of LFH remains uncertain. The current investigation observed notable increase in thrombospondin-1 (THBS1) expression through proteomics analysis and single-cell RNA-sequencing clinical specimens. In laboratory experiments, it was demonstrated that THBS1 triggered activation Smad3 signaling induced...