A5061689993- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Fungal and yeast genetics research
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Photosynthetic Processes and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Chromatin Dynamics
- Immune Response and Inflammation
- Historical Turkish Studies
- Immune cells in cancer
- Gender Studies and Social Issues
- Ottoman Empire History and Society
- Turkey's Politics and Society
- Olfactory and Sensory Function Studies
- Biofuel production and bioconversion
- Music Education and Analysis
- Values and Moral Education
- Viral Infections and Immunology Research
- HIV Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- Influenza Virus Research Studies
Koç University
2016-2025
Columbia University
2018
Viral infections may disrupt the structural and functional integrity of nervous system, leading to acute conditions such as encephalitis, neuropsychiatric mood disorders, schizophrenia, neurodegenerative diseases. Investigating viral interactions human proteins reveal mechanisms underlying these effects offer insights for therapeutic interventions. This study explores molecular virus that be related disorders. Herpes Simplex Virus-1 (HSV-1), Cytomegalovirus (CMV), Epstein-Barr Virus (EBV),...
During the generation and evolution of eukaryotic cell, a proteobacterial endosymbiont was re-fashioned into mitochondrion, an organelle that appears to have been present in ancestor all present-day eukaryotes. Mitochondria harbor proteomes derived from coding information located both inside outside organelle, rate-limiting step toward formation cells may development import apparatus allowing protein entry mitochondria. Currently, widely conserved translocon allows proteins pass cytosol...
Proteins localized to mitochondria by a carboxyl-terminal tail anchor (TA) play roles in apoptosis, mitochondrial dynamics, and protein import. To reveal characteristics of TAs that may be important for targeting, we focused our attention upon the TA Saccharomyces cerevisiae Fis1 protein. Specifically, generated library Fis1p variants fused Gal4 transcription factor, then, using next-generation sequencing, revealed which mutations inhibited membrane insertion allowed Gal4p activity nucleus....
Protein degradation is known to be a key component of expression regulation for individual genes, but its global impact on gene has been difficult determine. We analyzed parallel dataset yeast meiotic differentiation, identifying instances coordinated protein-level decreases identify new cases regulated protein degradation, including ribosomes and targets the meiosis-specific anaphase-promoting complex adaptor Ama1. Comparison translation measurements over time also revealed that, although...
Abstract Prokaryotes can provide new genetic information to eukaryotes by horizontal gene transfer (HGT), and such transfers are likely have been particularly consequential in the era of eukaryogenesis. Since highly compartmentalized, it is worthwhile consider mechanisms which newly transferred proteins might reach diverse organellar destinations. Toward this goal, we focused our attention upon behavior bacteria-derived tail anchors (TAs) expressed eukaryote Saccharomyces cerevisiae . In...
ABSTRACT During the generation and evolution of eukaryotic cell, a proteobacterial endosymbiont was refashioned into mitochondrion, an organelle that appears to have been present in ancestor all present-day eukaryotes. Mitochondria harbor proteomes derived from coding information located both inside outside organelle, rate-limiting step toward formation cells may development import apparatus allowing protein entry mitochondria. Currently, widely conserved translocon allows proteins pass...
ABSTRACT Proteins localized to mitochondria by a carboxyl-terminal tail anchor (TA) play roles in apoptosis, mitochondrial dynamics, and protein import. To reveal characteristics of TAs that may be important for targeting, we focused our attention upon the TA Saccharomyces cerevisiae Fis1 protein. Specifically, generated library Fis1p variants fused Gal4 transcription factor, then, using next-generation sequencing, revealed which mutations inhibited membrane insertion allowed Gal4p activity...
To better understand the gene regulatory mechanisms that program developmental processes, we carried out simultaneous, genome‐wide measurements of mRNA, translation and protein through meiotic differentiation in budding yeast. Surprisingly, observed levels several hundred mRNAs are anti‐correlated with their corresponding products. We show rather than arising from canonical forms control, regulation at least 380 such cases—or over 8% all measured genes—involves temporally regulated switching...