A5019008546- Research on Leishmaniasis Studies
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Extracellular vesicles in disease
- Trypanosoma species research and implications
- MicroRNA in disease regulation
- Vector-borne infectious diseases
- Hearing Loss and Rehabilitation
- Vascular Malformations and Hemangiomas
- Neurofibromatosis and Schwannoma Cases
- Circular RNAs in diseases
- Vascular Anomalies and Treatments
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Acute Ischemic Stroke Management
- Head and Neck Anomalies
- Head and Neck Surgical Oncology
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- IgG4-Related and Inflammatory Diseases
- Viral Infections and Vectors
- Cancer-related molecular mechanisms research
- Autoimmune Bullous Skin Diseases
- Trigeminal Neuralgia and Treatments
Universidade Estadual do Piau
2025
Fundação Getulio Vargas
2023
Massachusetts Eye and Ear Infirmary
2015-2023
Harvard University
2016-2023
Universidade de Brasília
2012-2016
University of California, San Diego
2016
Massachusetts General Hospital
2016
University of Amsterdam
2016
Universidade Federal do Piauí
2008-2014
Hospital Universitário de Brasília
2011-2012
Abstract Vestibular schwannomas (VSs) are the most common tumours of cerebellopontine angle. Ninety-five percent people with VS present sensorineural hearing loss (SNHL); mechanism this SNHL is currently unknown. To establish first model to study role VS-secreted factors in causing SNHL, murine cochlear explant cultures were treated human tumour secretions from thirteen different unilateral, sporadic VSs subjects demonstrating varied degrees ipsilateral SNHL. The extent damage due secretion...
Vestibular schwannoma (VS) is a tumor of the vestibular nerve that transmits balance information from inner ear to brain. Sensorineural hearing loss occurs in 95% patients with these tumors, but cause this not well understood. We posit role VS-secreted extracellular vesicles (EVs) as major contributing factor cochlear damage. Using differential centrifugation, we isolated EVs VS cell line HEI-193 and primary cultured human cells good or poor hearing. The were characterized using Nanosight...
Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide, frequently caused by noise trauma and aging, with inflammation being implicated in both pathologies. Here, we provide first direct measurements of proinflammatory cytokines inner ear fluid, perilymph, adolescent 2-year-old mice. The perilymph mice exposed to intensity resulting permanent auditory threshold elevations had significantly increased levels IL-6, TNF-α, CXCL1 6 h after exposure, elevated (19.3 ± 6.2...
Tuberculous otomastoiditis is a rare disease. Diagnosis generally occurs late when the patient already has irreversible sequelae. Two cases are reported with an unusual presentation of coalescent mastoiditis caused by Mycobacterium tuberculosis. The patients underwent several antibiotic treatments without clinical improvement, evolving temporal bone erosion and severe/profound hearing loss. Maintaining high degree suspicion regarding this entity important to obtain early diagnosis,...
The diagnosis of visceral leishmaniasis (VL) is still a major problem in Brazil and several other countries where the disease endemic. use an easy-to-use interpret, sensitive, specific method that requires no complex infrastructure or specialized professionals, such as direct agglutination test (DAT) rK39-based rapid immunochromatographic may enhance disease. This study evaluated performance (DiaMed- IT-LEISH®) DAT for VL 213 parasitologically confirmed cases 119 controls with clinical...
ResumoO teste imunocromatográfico rápido IT-LEISH® (DiaMed IT-LEISH®) foi validado para o diagnóstico da leishmaniose visceral (LV) em quatro áreas endêmicas do Brasil.O desempenho comparado ao reação de imunofluorescência indireta; e imunoenzimática, usando-se antígeno solúvel Leishmania chagasi recombinante K39 (rK39).O estudo incluiu 332 pacientes com quadro clínico sugestivo LV: 213 casos LV confirmados parasitologicamente; 119 não-casos, confirmação outra etiologia.O apresentou...
The AIDS epidemic has become a worldwide phenomenon of enormous magnitude and extension, deeply transforming medical practices public health initiatives. This retrospective survey aimed to analyze clinical epidemiological characteristics patients with HIV/AIDS admitted the Institute Tropical Diseases Natan Portella, Teresina, Piauí, Brazil, from January, 2001 through December, 2004. Of 828 patients, 43% were other states 71.3% men. Average patient age was 35.4 +/- 11.5 years-old 85.5%...
Knowledge of the population in regards to stroke has clinical and epidemiological importance. Prompt identification symptoms means efficient medical attendance within window therapeutic opportunities reducing significantly morbidity-mortality. Our aim was evaluate level knowledge Teresina (PI) concerning factors risk, treatment stroke. The door-to-door study carried out by a standardized application questionnaire on risk factors, attitude when faced with victim. 991 forms were selected....
An analysis of the dietary content haematophagous insects can provide important information about transmission networks certain zoonoses. The present study evaluated potential polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) mitochondrial cytochrome B (cytb) gene to differentiate between vertebrate species that were identified as possible sources sandfly meals. complete cytb sequences 11 available in National Center for Biotechnology Information database digested...
Knowledge on the anatomy of sphenopalatine artery (SPA) and its branches is fundamental for success endoscopic treatment posterior epistaxis. However, complex anatomical variations seen in irrigation nasal cavity poses a significant surgical challenge.This paper aims to describe SPA human cadavers.This contemporary cross-sectional cohort study carried out between April 2010 August 2011. The presence ethmoidal crest lamina perpendicular palatine bone location principal foramen (PSF) accessory...
Summary Tumor necrosis factor ( TNF ) family cytokines are important mediators of inflammation. Elevated levels serum ‐α associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression ‐related apoptosis‐inducing ligand TRAIL and its signaling death receptor 5 DR 5) in murine inner ear show that exogenous can trigger hair cell neuronal degeneration, which be partly prevented 5‐blocking antibodies.
Introduction Vestibular schwannoma (VS) is an intracranial tumor that arises on the vestibular branch of cranial nerve VIII and typically presents with sensorineural hearing loss (SNHL). The mechanisms this SNHL are postulated to involve alterations in inner ear’s microenvironment mediated by genetic cargo VS-secreted extracellular vesicles (EVs). We aimed identify EV associated poor determine whether its delivery caused cochlear damage a mouse model vivo. Methods VS tissue was collected...
Eagle's syndrome is characterized by cervicopharyngeal signs and symptoms associated with elongation of the styloid apophysis. This may occur through ossification stylohyoid ligament, or growth apophysis due to osteogenesis triggered a factor such as trauma. Elongation give rise intense facial pain, headache, dysphagia, otalgia, buzzing sensations, trismus. Precise diagnosis difficult, it generally confounded other manifestations pain. To describe case syndrome. A 53-year-old man reported...
1 Graduation (Otorhinolaryngologist, Brasilia University). 2 (Otorhinolaryngology Medical Resident, 3 (Assistant Professor, Department of Otorhinolaryngology and Head Neck Surgery, 4 PhD in Sciences, ENT Department, University Sao Paulo (Adjunct 5 Federal Hospital Surgery. Send correspondence to: Vitor Yamashiro Rocha Soares. SGAN, Via L2 Norte, Quadra 604/605, Asa HUB, Anexo III. CEP: 70840-050. Tel: 55 (61) 8130-0972. Email: vyrsoares@yahoo.com.br Paper submitted to the BJORL-SGP...
Knowledge of genotype distribution hepatitis C virus (HCV) has clinical importance due to 1 lower response treatment compared with genotypes 2 and 3. The goal this survey was describe laboratorial profiles patients chronic (CHC) in the State Piauí, as well expand overall awareness HCV genotyping Northeast Brazil. A retrospective cross-sectional study carried out between April 1999 August 2005. total 153 were included, 119 (77.8%) males 34 (22.2%) females; mean age = 48.01 ± 9.11 years. We...
We present a case of hepatectomy in patient with liver's lymphangioma associated Situs Inversus Totalis.The first medical literature.
To review key evidence-based recommendations for the diagnosis and treatment of peripheral facial palsy in children adults. Task force members were educated on knowledge synthesis methods, including electronic database search, selection relevant citations, critical appraisal selected studies. Articles written English or Portuguese eligible inclusion. The American College Physicians' guideline grading system Thyroid Association's criteria used evidence therapeutic interventions. topics...
The major objective of a stapedotomy is the restoration hearing. In training centers, hearing results obtained by resident physicians are lower than those achieved more experienced surgeons. An analysis surgical essential to identification deficiencies in learning process.To analyze postoperative otosclerosis patients who underwent performed surgeons residency program.The pre- and audiometric were evaluated retrospective study 98 from January 2000 December 2010.The distribution according was...
Imaging of the cochlea and internal auditory canals are increasingly important nowadays because growing number cochlear implants being performed throughout world. We report a case 4-year-old boy who was born deaf evaluated in our service for possible implantation. Audiometry disclosed profound bilateral deafness. The magnetic resonance imaging revealed only two nerves each inner canal: one anterior superior quadrant, identified as facial nerve, on posterior quadrants, representing both...