A5038566355- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Prion Diseases and Protein Misfolding
- Mesenchymal stem cell research
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Prenatal Screening and Diagnostics
- Single-cell and spatial transcriptomics
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Multiple Sclerosis Research Studies
- Light effects on plants
- AI in cancer detection
- Calcium signaling and nucleotide metabolism
- SARS-CoV-2 and COVID-19 Research
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Plant Molecular Biology Research
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
Centre for Research and Technology Hellas
2015-2021
Tel Aviv University
2019
Aristotle University of Thessaloniki
2006-2013
G. Papanikolaou General Hospital
2011
Papageorgiou General Hospital
2011
Significance CLL is characterized by autonomous B cell receptor (BCR) signaling. subsets are empirically defined sequence similarities of the BCR heavy chain. However, in unfavorable subset 2, an acquired mutation (termed R110) light chain stimulates This study demonstrates that oncogenic R110 dictates prognosis and not restricted to conventional 2. Interestingly, carriers a particular light-chain allele ( IGLV3-21 * 01 ) predisposed develop because this enables signaling as single-point...
Terpenoids (isoprenoids) have numerous applications in flavors, fragrances, drugs and biofuels. The number of microbially produced terpenoids is increasing as new biosynthetic pathways are being elucidated. However, efforts to improve terpenoid production yeast mostly taken advantage existing knowledge the sterol pathway, while many additional factors may affect output engineered system.Aiming develop a strain that can support high titers sclareol, diterpene great importance for perfume...
The safety and efficacy of hematopoietic stem cell (HSC) mobilization was investigated in adult splenectomized (SPL) non-SPL patients with thalassemia major, two clinical trials, using different modes: granulocyte-colony-stimulating factor (G-CSF)-alone, G-CSF following pretreatment hydroxyurea (HU), plerixafor-alone. G-CSF-mobilization both safe effective patients. However, SPL the procedure resulted excessive response to G-CSF, expressed as early hyperleukocytosis necessitating significant...
Prions are postulated to be the infectious agents of a family transmissible, fatal, neurodegenerative disorders affecting both humans and animals. The possibility prion transmission constitutes public-health risk that confronts regulatory authorities everywhere. main problem in handling prions is fact they extremely resistant standard decontamination methods. Thus, use harsh expensive practices destroy inevitable. development applicable efficient prion-inactivation still highly important for...
// Nikos Papakonstantinou 1,2,* , Stavroula Ntoufa Elisavet Chartomatsidou 1 Konstantia Kotta Andreas Agathangelidis 3 Lefki Giassafaki Tzeni Karamanli Panagiota Bele Theodoros Moysiadis Panagiotis Baliakas 2 Lesley Ann Sutton Niki Stavroyianni 4 Achilles Anagnostopoulos Antonios M. Makris Paolo Ghia Richard Rosenquist and Kostas Stamatopoulos 1,2,4 Institute of Applied Biosciences, Center for Research Technology Hellas, Thessaloniki, Greece Department Immunology, Genetics Pathology, Science...
Abstract Background Transmissible spongiform encephalopathies (TSEs), a group of neurodegenerative diseases, are thought to be caused by an abnormal isoform naturally occurring protein known as cellular prion protein, PrP C . The form Sc accumulates in the brain affected individuals. Both isoforms encoded same gene ( PRNP ), and structural changes occur post-translationally. Certain mutations result genetic TSEs or increased susceptibility TSEs. Case presentation A 70 year old woman was...
Key Points Microenvironmental stimuli affect EZH2 expression and function in CLL. Combined B-cell signaling inhibition showed synergistic effects on primary CLL cells.
Summary The conformational transition of α‐helix‐rich cellular prion protein (PrP C ) to an isomer with high β‐sheet content is associated transmissible spongiform encephalopathies. With the ultimate long‐term goal using imaging techniques study PrP aggregation, we report results initial experiments determine whether molecules could be visualized as single molecules, and if observed size corresponded calculated for PrP. investigation not those embedded into larger aggregates, was key in our...
Naphthodianthrones such as fagopyrin and hypericin found mainly in buckwheat (Fagopyrum spp.) St. John’s wort (SJW) (Hypericum perforatum L.) are natural photosensitizers inside the cell. The effect of was studied under dark conditions on growth, morphogenesis induction death Saccharomyces cerevisiae. Fagopyrin induced a biphasic triphasic dose response cellular respectively, over 10-fold concentration change. In fagopyrin-treated cells, disruptions normal cell cycle progression were evident...
It has been proposed that vitamin D may play a role in prevention and treatment of cancer while epidemiological studies have linked insufficiency to adverse disease outcomes various B cell malignancies, including chronic lymphocytic leukemia (CLL). In this study, we sought obtain deeper biological insight into the its receptor (VDR) pathophysiology CLL. To end, performed expression analysis pathway molecules; complemented by RNA-Sequencing primary CLL cells were treated vitro with...
The inflammatory cytokine Stem Cell Factor (SCF, ligand of c-kit receptor) has been implicated as a pro-oncogenic driver and an adverse prognosticator in several human cancers. Increased SCF levels have recently reported small series patients with chronic lymphocytic leukemia (CLL), however its precise role CLL pathophysiology remains elusive. In this study, cells were found to predominantly express the membrane isoform that is known elicit more robust activation receptor. was significantly...
Flow cytometry (FC) is widely used for diagnostic purposes in clinical practice. This analysis typically aims at clustering cellular events according to their biological characteristics, known as gating, and then use the selected clusters order conclude about outcomes. As each step of this process highly subjective, various proposed methods have attempted automate procedure separately, but any method has been whole process. We constructed a tool that simulates experts decisions during if...