A5065452746- Prion Diseases and Protein Misfolding
- Advanced Photocatalysis Techniques
- TiO2 Photocatalysis and Solar Cells
- Healthcare and Environmental Waste Management
- Neurological diseases and metabolism
- Pharmaceutical and Antibiotic Environmental Impacts
- Monoclonal and Polyclonal Antibodies Research
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Food Allergy and Anaphylaxis Research
- Polyamine Metabolism and Applications
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Trace Elements in Health
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Endoplasmic Reticulum Stress and Disease
Aristotle University of Thessaloniki
2005-2024
AHEPA University Hospital
2020
Laboratoire de Chimie
2012-2013
MRC Prion Unit
2013
Centre for Research and Technology Hellas
2003
Prions are postulated to be the infectious agents of a family transmissible, fatal, neurodegenerative disorders affecting both humans and animals. The possibility prion transmission constitutes public-health risk that confronts regulatory authorities everywhere. main problem in handling prions is fact they extremely resistant standard decontamination methods. Thus, use harsh expensive practices destroy inevitable. development applicable efficient prion-inactivation still highly important for...
Abstract BACKGROUND Recombination of photogenerated carriers in titanium dioxide (TiO 2 )‐mediated semiconducting photocatalysis is considered to be the principal obstacle its unlimited exploitation practical applications. Hybridization TiO with graphene‐based materials appears a highly promising alternative. In this context, reduced graphene oxide (rGO)/TiO composites were prepared using simple ultrasonically assisted route under mild reaction conditions. RESULTS The as‐prepared...
Photocatalytic inactivation of pathogens in aqueous waste is gaining increasing attention. Several homogeneous and heterogeneous photocatalytic protocols exist using the Fenton's reagent TiO2, respectively. A comprehensive study photocatalysis on a range microorganisms will significantly establish most efficient method. Here, we report comparative TiO2- Fe+3-based under UV-A diverse microorganisms, including Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli) bacteria,...
Abstract Background Transmissible spongiform encephalopathies (TSEs), a group of neurodegenerative diseases, are thought to be caused by an abnormal isoform naturally occurring protein known as cellular prion protein, PrP C . The form Sc accumulates in the brain affected individuals. Both isoforms encoded same gene ( PRNP ), and structural changes occur post-translationally. Certain mutations result genetic TSEs or increased susceptibility TSEs. Case presentation A 70 year old woman was...
Prions are notorious for their extraordinary resistance to traditional methods of decontamination, rendering transmission a public health risk. Iatrogenic Creutzfeldt-Jakob disease (iCJD) via contaminated surgical instruments and medical devices has been verified both experimentally clinically. Standard prion inactivation by sodium hydroxide or hypochlorite have failed, in some cases, fully remove infectivity, while they often impractical routine applications. Prion accumulation peripheral...
Abstract BACKGROUND Treatment of liquid hazardous medical wastewater produced by healthcare laboratories is a global matter that has been inadequately addressed. In this study, the potential heterogeneous and homogeneous photocatalytic oxidation to detoxify disinfect such effluents was investigated. Experiments were performed using two toxic one simultaneous infectious composition in pilot scale, novel inactivation system. RESULTS Photocatalytic experimental runs with both showed...
Prion diseases are fatal, neurodegenerative characterized by the structural conversion of normal, cellular prion protein, PrPC into an abnormally structured, aggregated and partially protease-resistant isoform, termed PrPSc. Although substantial research has been directed toward development therapeutics targeting prions, there is still no curative treatment for disease. Benzoxazines bicyclic heterocyclic compounds possessing several pharmaceutically important properties, including...
Prions are proteinaceous pathogens responsible for a variety of devastating diseases in mammals, including scrapie sheep and goats, chronic wasting disease cervids, Creutzfeldt–Jakob (CJD) humans. They characterized by their exceptional persistence to common inactivation procedures. This applies all possible sources prion contamination as prions may be present the tissues biological fluids infected individuals. Hence, efficient procedures still being sought minimize risk intra- or...
The discovery of neural precursor cells (NPCs) and the concomitant intensive research in field offer regenerative medicine novel approaches, enabling it to tackle conditions, such as neurodegenerative diseases. Transplantation NPCs is nowadays considered a cutting-edge treatment for these conditions many related clinical trials have been already completed or are still ongoing. However, little known about antigenicity NPCs, with most studies addressing question whether their could lead...