A5066235148- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Erythropoietin and Anemia Treatment
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Diverse Scientific Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Asthma and respiratory diseases
- Acute Kidney Injury Research
- Allergic Rhinitis and Sensitization
- Healthcare and Venom Research
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA regulation and disease
- Tissue Engineering and Regenerative Medicine
- Cancer, Hypoxia, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Neurogenesis and neuroplasticity mechanisms
Aristotle University of Thessaloniki
2013-2024
National and Kapodistrian University of Athens
2022
AHEPA University Hospital
2008
St. Christopher's Hospital for Children
1998-2001
Hahnemann University Hospital
2001
Winthrop-University Hospital
1999
Drexel University
1999
University of Pennsylvania
1998
Allegheny College
1998
Erythropoietin (EPO), originally identified for its critical role in promoting erythrocyte survival and differentiation, has been shown to exert multiple paracrine/autocrine functions. Protective effects of EPO have demonstrated various tissues experimental models ischaemia-induced injury. In the present study, we investigated effect on an vivo rat model renal ischaemia/reperfusion (I/R) injury possible mechanisms implicated EPO-mediated anti-apoptotic action.Male Wistar rats, subjected...
Exposure to environmental enrichment can beneficially influence the behavior and enhance synaptic plasticity. The aim of present study was investigate mediated effects on postnatal stress-associated impact with regard behavior, stress reactivity as well plasticity changes in dorsal hippocampus. Wistar rat pups were submitted a 3 h maternal separation (MS) protocol during days 1-21, while another group left undisturbed. On day 23, subgroup from each rearing condition (maternal separation,...
Inhibition of the myelin-associated neurite outgrowth inhibitor Nogo-A has been found to be beneficial in experimental autoimmune encephalomyelitis (EAE), but there are little data on its expression dynamics during disease course. We analyzed mRNA and protein course EAE 27 C57BL/6 mice 8 controls. Histopathologic molecular analyses were performed Day 0 (naive), preclinical (Day 10), acute (Days 18–22) chronic 50) time points. In situ hybridization real-time polymerase chain reaction revealed...
Stress-related mental disorders have become increasingly prevalent, thus endangering health worldwide. Exploring stress-associated brain alterations is vital for understanding the possible neurobiological mechanisms underlying these changes. Based on existing evidence, endogenous cannabinoid system (ECS) plays a significant role in stress response, and disruptions its function are associated with neurobiology of various stress-related disorders. This study primarily focuses investigating...
Perinatal asphyxia (PA) is a major determinant for long-term sensorimotor and locomotor deficits. The model of neonatal hypoxia-ischemia (HI) in 7-day-old rats produces cortex, thalamus striatum injury, which are all critical the maintenance sensory motor function. aim this study was to evaluate neurodevelopmental disturbances above experimental assess neuroprotective effect MgSO(4) terms behavioral morphological changes. Seven-day-old were separated into three groups: A (control), neither...
Both heat acclimation (HA) and post-injury treatment with recombinant human erythropoietin (Epo, rhEpo, exogenous Epo) are neuroprotective against traumatic brain injury (TBI). Our previous data demonstrated that HA-induced neuroprotection includes improved functional recovery reduced cerebral edema formation. Additionally, in earlier Western-blot analyses, we found HA mice display increased expression of the specific receptor (EpoR) hypoxia-inducible factor-1 alpha (HIF-1 alpha), inducible...
Exposure to early-life stress is associated with long-term alterations in brain and behavior, may aggravate the outcome of neurological insults. This study aimed at investigating possible interaction between maternal separation, a model early stress, subsequent neonatal hypoxia-ischemia on emotional behavior markers synaptic plasticity hippocampus. Therefore, rat pups (N=60) were maternally separated for prolonged (MS 180min) or brief 15min) period during first six postnatal days, while...
Hypoxic ischemic (HI) brain injury that occurs during neonatal period has been correlated with severe neuronal damage, behavioral deficits and infant mortality. Previous evidence indicates N-acetylcysteine (NAC), a compound antioxidant action, exerts potential neuroprotective effect in various neurological disorders including induced by ischemia. The aim of the present study was to investigate role NAC as therapeutic agent rat model HI explore its long-term effects. To this end, (50...
Background The pathophysiologic mechanism of allergy is dependent on the action many redox‐sensitive proinflammatory mediators. However, even though redox disturbances are believed to be a hallmark inflammation, little known effect imbalance pathophysiology allergic rhinitis. We thus opted investigate relation oxidative stress and rhinitis, through utilization potent antioxidant substance (N‐acetylcysteine [NAC]) in rat model rhinitis evaluation its specific markers inflammation. Methods NAC...
Purkinje cells (PCs) are vulnerable to hypoxic/ischemic insults and rich in calcium calcium-buffering/sequestering systems, including calcium-binding proteins (CaBPs). Calbindin-D28k is an EF-hand CaBP, which highly expressed pCs where it acts primarily as a cellular Ca++ buffer. Elevation of [Ca++] the cytosol nuclei pivotal cell death. We hypothesize that hypoxia results decreased concentration, or availability calbindin-D28k pCs, thereby decreasing their buffering capacity resulting...
Abstract This study aims at investigating whether early stress interacts with brain injury due to neonatal hypoxia‐ischemia (HI). To this end, we examined possible changes in synaptophysin (SYN) and brain‐derived neurotrophic factor (BDNF) expression the medial prefrontal cortex (mPFC) of maternally separated rats that were subsequently exposed a HI episode. Rat pups ( n = 11) during postnatal days 1 6 (3hr/day), while another group was left undisturbed 11). On day 7, subgroup 12) from each...