A5057796493- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Pregnancy and Medication Impact
- Pediatric Hepatobiliary Diseases and Treatments
- Pressure Ulcer Prevention and Management
- Pregnancy and preeclampsia studies
- Drug Transport and Resistance Mechanisms
- Lung Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- Wound Healing and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- BRCA gene mutations in cancer
- Economic and Financial Impacts of Cancer
- Pharmaceutical Economics and Policy
- Cardiac Ischemia and Reperfusion
- Genetic factors in colorectal cancer
- Liver Diseases and Immunity
- Metabolism and Genetic Disorders
- Intensive Care Unit Cognitive Disorders
Wexham Park Hospital
2002-2021
Cancer Research UK
2012-2021
Frimley Health NHS Foundation Trust
2019-2021
Cancer Research Horizons
2016-2018
The University of Texas Southwestern Medical Center
2014
Caris Life Sciences (United States)
2012
Bedford Hospital
2011
Papworth Hospital
1990-1992
Objective To explore the clinical features of obstetric cholestasis pregnancies in UK white Caucasians. Design A questionnaire survey. Setting Study coordinated at Queen Charlotte's Hospital. Population Clinical 352 affected 227 Caucasian women identified via a patient support group. Methods Evaluation gestation which prematurity and intrauterine death occur, recording additional complicated by cholestasis. Main outcome measures The timing prematurity. Results Among pregnancies, 23 (7%) were...
If we are to beat cancer, early detection and diagnosis arguably the most effective means have at our disposal. Progress during past 40 years has transformed prospects of people diagnosed with cancer in UK, survival doubling since 1970s.1Quaresma M Coleman MP Rachet B 40-year trends an index for all cancers combined adjusted age sex each England Wales, 1971–2011: a population-based study.Lancet. 2014; 385: 1206-1218Summary Full Text PDF PubMed Scopus (336) Google Scholar However, further...
BackgroundThe management of NSCLC has been transformed by stratified medicine. The National Lung Matrix Trial (NLMT) is a UK-wide study exploring the activity rationally selected biomarker/targeted therapy combinations.Patients and methodsThe Cancer Research UK (CRUK) Stratified Medicine Programme 2 undertaking large volume national molecular pre-screening which integrates with NLMT. At initiation, there are eight drugs being used to target 18 cohorts. aim determine whether sufficient signal...
Reversible detyrosination of tubulin, the building block microtubules, is crucial for neuronal physiology. Enzymes responsible were recently identified as complexes vasohibins (VASHs) one or two with small VASH-binding protein (SVBP). Here we report three consanguineous families, each containing multiple individuals biallelic inactivation SVBP caused by truncating variants (p.Q28* and p.K13Nfs*18). Affected show brain abnormalities microcephaly, intellectual disability delayed gross motor...
Background The variability of Covid-19 severity between patients has driven efforts to identify prognosticating laboratory markers that could aid clinical decision-making. Procalcitonin is classically used as a diagnostic marker in bacterial infections, but its role predicting disease emerging. We aimed the association procalcitonin and critical care setting whether co-infection implicated. Methods retrospectively reviewed with concentrations measured at our institution February September...
#### Learning points A 34 year old South Asian nursery worker presented to her general practitioner at 32 weeks’ gestation in first pregnancy complaining of increasingly severe itching. There was no relevant medical or family history, and she not taking regular medication. Physical examination normal with evident rash. Her blood pressure 115/65 mm Hg, there proteinuria. The liver function tests were: total bilirubin 6 μmol/L, alkaline phosphatase 178 IU/L, alanine transaminase 42 IU/L,...
To evaluate enzymatic total serum bile acid quantification as a monitoring strategy for women with intrahepatic cholestasis of pregnancy (ICP) treated ursodeoxycholic (UDCA).Cohort.One UK university hospital.29 ICP cases UDCA.Serial samples were collected prospectively throughout gestation. Total acids measured enzymatically and individual by high-performance liquid chromatography-tandem mass spectrometry. Data log-transformed analysed random effects generalised least square regression.The...
Objective: To investigate whether women with preeclampsia and abnormal liver function tests have raised serum bile acids. Design: Measurement of acids in specimens collected at the John Radcliffe Hospital, Oxford. Setting: Imperial College School Medicine. Sample: Stored sera from 37 19 controls. Methods: Enzymic total acid assay. Main outcome measures: Total levels. Results: Women had higher median levels than controls (5.7 vs. 3.2, p = 0.01). The reason for patient group is that three (8%)...
This study seeks to establish the normal serum concentrations of biochemical markers related nutrition, inflammation and disease, investigate how levels change with age diet in rat. To this end, we fed rats from weaning on three diets differing their protein, carbohydrate fatty acid content. The consisted a control, nutritionally balanced diet, same supplemented 10% (wt/wt) beef tallow, that was high fat low protein. Blood samples at two different ages, 3 months 12 months, were then...
This paper investigates a novel in vitro method of ascertaining quantitative comparative data on selection commercially available odour adsorbent wound dressings. The aim this study is to determine and evaluate desirable the efficiency adsorbency along with other comparable physical characteristics commercial part an ongoing research programme into design development dressings for managing malodorous wounds. also includes controlled test that simulates more realistic situation. A activated...
It is unclear whether electrographic features are predictive of ketogenic diet efficacy and how evolution electroencephalogram (EEG) findings correlates with clinical improvement. We aimed to identify predictors for seizure reduction on the as it serial EEGs. reviewed 89 patients at Children’s Medical Center from 2005 2012. developed scoring criteria analyze EEG characteristics (2 scales: 0-3 encephalopathy; 0-6 interictal discharges). Those lowest encephalopathy scores last strongly...
11094 Background: The Stratified Medicine Programme is demonstrating large scale molecular testing of solid tumours in the UK using a range technologies. collaborative model has allowed three laboratories to share and compare data on mutation frequencies including exclusivity, test turnaround times failure rates, inform future routine service for clinical care. Methods: Phase One two-year pilot study analysis surplus diagnostic FFPE tumour tissue obtained from patients with cancer breast,...
IntroductionPhase I of the Cancer Research UK Stratified Medicine Programme (SMP1) was designed to roll out molecular pathology testing nationwide at point cancer diagnosis, as well facilitate an infrastructure where surplus tissue could be used for research. It offered a non-trial setting examine common genetics in real-world context.MethodsA total 26 sites England, Wales and Scotland, recruited samples from 7814 patients genetic examination between 2011 2013. Tumour types involved were...
11079 Background: Increasing demand for testing multiple markers targeted therapies requires a platform to incorporate molecular diagnostics in the normal pathway of care. This programme was planned demonstrate applicability nationwide testing, linked healthcare records central database. Methods: From 8/2011 6/2013, patients with breast, colorectal, prostate, lung or ovarian cancer, melanoma, were approached at 26 hospitals consent centralised routine biopsies. Formalin-fixed...