A5084534450- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Hemophilia Treatment and Research
- Lymphoma Diagnosis and Treatment
- Case Reports on Hematomas
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood disorders and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmacogenetics and Drug Metabolism
- Enzyme function and inhibition
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Chronic Lymphocytic Leukemia Research
- Hormonal Regulation and Hypertension
- Liver Disease and Transplantation
- Cardiac tumors and thrombi
- Hepatitis C virus research
- Clusterin in disease pathology
- Vitamin K Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cognitive and psychological constructs research
- Aldose Reductase and Taurine
- Hemostasis and retained surgical items
- Cardiovascular Issues in Pregnancy
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
2008-2024
Azienda Sanitaria Locale Alessandria
1990-2019
University of Debrecen
2019
University of Modena and Reggio Emilia
2017
Presidio Ospedaliero
2016
Thrombosis Research Institute
2010
Universitat de Barcelona
2005
New Frontier
1998
University of Pavia
1983
Abstract Heparins and vitamin K antagonists are the mainstay of treatment splanchnic vein thrombosis (SVT). Rivaroxaban is a potential alternative, but data to support its use limited. We aimed evaluate safety efficacy rivaroxaban for acute SVT. In an international, single-arm clinical trial, adult patients with first episode noncirrhotic, symptomatic, objectively diagnosed SVT received 15 mg twice daily 3 weeks, followed by 20 intended duration months. Patients Budd-Chiari syndrome those...
Intracranial haemorrhage is a serious and potentially fatal complication of oral anticoagulant therapy. Prothrombin complex concentrates can substantially shorten the time needed to reverse effects anticoagulants. The aim this study was determine efficacy safety prothrombin concentrate for rapid reversal therapy in patients with intracranial haemorrhage.Patients receiving suffering from acute were eligible prospective cohort if their International Normalised Ratio (INR) higher than or equal...
Acquired haemophilia A (AHA) is a rare bleeding disorder due to autoantibodies coagulation factor VIII that may be secondary autoimmune diseases, cancer, drugs, pregnancy, infections, or idiopathic. Recurrent bleeding, often severe, mostly in muscles and soft tissues, isolated prolonged activated partial thromboplastin time (aPTT), the absence of personal family history are typical features should raise suspicion AHA. Poor awareness disease results diagnostic delays inappropriate...
Summary Current data suggests that the risk of venous thromboembolism (VTE) in patients with non-Hodgkin lymphoma (NHL) is comparable to observed solid tumours, although more robust confirmatory analyses are required. With mind, we investigated occurrence VTE a pooled analysis 12 “Fondazione Italiana Linfomi” (FIL) prospective clinical studies. Specifically, wished assess cumulative incidence NHL patients, evaluate predictive value Khorana Score (KS), and identify other potential factors for...
Inherited dysfibrinogenemia is a rare disorder, for which clinical studies related to the risk of bleeding or thrombosis and type causative mutation are scanty.We analyzed laboratory, clinical, genotypic features 50 patients with inherited belonging 19 unrelated families.In all index cases, fibrinogen activity by Clauss method was below normal range, while it observed in 57.9% only PT-derived method. In three families, hypodysfibrinogenemia evident, associated novel mutations (Ter492Gln FGB,...
<i>Background:</i> Intracranial haemorrhage (ICH) is a serious and potentially fatal complication of oral anticoagulant therapy (OAT). Prothrombin complex concentrates (PCCs) produce rapid effective reversal OAT effects, but little evidence exists on their efficacy safety in the management ICH patients OAT. <i>Aim:</i>To evaluate PCCs for with ICH. <i>Methods:</i> Patients suffering from acute while receiving were eligible this prospective cohort study if...
It is generally recommended that patients with splanchnic vein thrombosis (SVT) should receive a minimum of 3 months anticoagulant treatment. However, little information available on the long-term risk recurrent thrombotic events. The aim this study was to evaluate venous and arterial after discontinuation vitamin K antagonist (VKA) in SVT patients. Retrospective from cohort treated VKA followed by 37 Italian Anticoagulation Clinics, up June 2013, collected. Only who discontinued did not any...
Regular physical activity can increase joint stability and function, reduce the risk of injury, improve quality life people with haemophilia (PwH). However, a recent review literature shows that appropriate sport are not always promoted enough in overall management PwH. A group Italian experts care undertook consensus procedure to provide practical guidance on when how recommend exercise programmes PwH clinical practice. Three main topics were identified-haemophilia its impact movement,...
Clusterin is a multifunctional glycoprotein associated with development and tissue injury. Because renal function decreases advancing age in the obese Zucker rat, clusterin mRNA expression was examined kidney of young adult rats compared age-related changes Fischer 344 (F344) rats. Renal levels rat were 2.5-fold higher by 3 mo fourfold at 5 lean strain. In comparison, 12-mo-old F344 twofold than 3-mo-old animals tenfold 24 age. positively correlated urinary protein excretion negatively...
The prevention of phosphate retention in chronic renal disease may reduce both osteodystrophy and progression. We evaluated the expression sodium-dependent transporter, NaPi-2, response to phosphonoformic acid (PFA) rats with 5/6 nephrectomy-induced failure. Partial nephrectomy resulted a significant proteinuria reduced function. In addition, there was an approximately 50% reduction NaPi-2 mRNA. Treatment for 48 hr PFA (0.6% glucose drinking fluid) had no effect on mRNA; however, increase...
SB 203220, [(E)-alpha-[[2-butyl-1-[(4-carboxy-1-naphthalenyl)-methyl]-1H- imidazol-5-yl]-methylene]-2-thiophene-propanic acid], is a novel nonpeptide angiotensin II receptor antagonist with significant oral activity. In the present study, we compared cardiovascular and renal effects of 203220 captopril in rats chronic failure induced by 5/6 nephrectomy. Preliminary studies indicated that (600 ppm diet) (250 mg/l drinking water) significantly attenuated pressor activity exogenous I,...
Background Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare autoimmune condition characterized by acquired prothrombin (FII) deficiency associated with antiphospholipid (APS) and life-threatening bleeding. We present the case of 34-year-old woman heavy menstrual bleeding (HMB), positive (LA) test, high titer anticardiolipin antibodies Immunoglobulin G (ACA IgG) anti-β2 glycoprotein I IgG (antiB2GPI IgG). Severe iron anemia necessitated recurrent blood transfusions...
There is evidence to suggest that thromboxane synthesis inhibition will attenuate the hypertension and proteinuria associated with subtotal renal ablation. In present study, receptor antagonist, daltroban, (30 mg/kg/day i.p.) or vehicle was administered rats for 3 weeks starting 2 after partial ablation (right uninephrectomy ligation of approximately two-thirds blood supply left kidney). Renal increased systolic pressure. Neither nor affected by daltroban administration. Histological...