A5086356713- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Cancer-related gene regulation
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Blood properties and coagulation
- Diagnosis and Treatment of Venous Diseases
- Pharmacogenetics and Drug Metabolism
- Heparin-Induced Thrombocytopenia and Thrombosis
- Atrial Fibrillation Management and Outcomes
- Reproductive Health and Contraception
- Statistical Methods in Clinical Trials
- Potassium and Related Disorders
- Adolescent and Pediatric Healthcare
- Autoimmune Bullous Skin Diseases
- Orthopaedic implants and arthroplasty
- Hemostasis and retained surgical items
- Chronic Disease Management Strategies
- Tendon Structure and Treatment
- Pregnancy and preeclampsia studies
- Erythrocyte Function and Pathophysiology
- Hepatitis C virus research
Istituto delle Scienze Neurologiche di Bologna
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Azienda USL di Bologna
2022
Policlinico S.Orsola-Malpighi
2003-2021
University of Bologna
2002-2021
University of Ferrara
2003
Istituto Oncologico Romagnolo
2002
Baxter (Austria)
2002
Background— We have shown that normal D-dimer levels obtained after the discontinuation of oral anticoagulant treatment (OAT) has a high negative predictive value for recurrent venous thromboembolism (VTE). The aim present study was to assess VTE in subjects with previous unprovoked event who are either carriers inherited thrombophilia or not. Methods and Results— prospectively evaluated 599 patients (301 males) episode. They were repeatedly examined OAT withdrawal screened thrombophilic...
Summary The natural history of calf deep-vein thrombosis (DVT) is still uncertain and it debated whether warrants to be diagnosed treated. We aimed investigate the complication rate untreated isolated DVT (ICDVT). Symptomatic outpatients were prospectively managed with serial compression ultrasonography (SCUS). Those without proximal likely pre-test clinical probability (PCP) or altered D-dimer received immediate subsequent complete examination deep veins (CCUS) by a different operator....
Haemophilia, a genetic disorder characterised by deficient clotting factors, often leads to musculoskeletal complications such as haemophilic arthropathy. These result in reduced functional capacity, muscle weakness and kinesiophobia, which further exacerbate physical inactivity psychological distress. The World Federation of Haemophilia recommends including regular activity the management plans for individuals with haemophilia, emphasising its benefits bone strengthening, improved...
Abstract Background: Venous thromboembolism (VTE) is a major complication of myeloma therapy recently observed with the increasing use up‐front thalidomide and dexamethasone (thal–dex). The pathogenesis thal‐induced VTE not well recognized, role prothrombotic factors, especially thrombophilic abnormalities, yet determined. Material methods: Two hundred sixty‐six patients newly diagnosed multiple (MM) were primarily treated thal–dex in preparation for subsequent high‐dose autologous stem‐cell...
Summary Von Willebrand disease ( VWD ) is an inherited bleeding disorder caused by the quantitative or qualitative deficiency of von factor VWF ). Replacement therapy with plasma‐derived /factor VIII FVIII concentrates required in patients unresponsive to desmopressin. To assess efficacy, safety and ease use a new, volume‐reduced VR formulation / concentrate Haemate ® P requiring treatment for prophylaxis recurrent invasive procedures. Pharmacoeconomic variables were also recorded. Data...
Summary. A Registry of inherited bleeding disorders was set up in the Region Emilia‐Romagna (RER) to collect information about these diseases and improve quality care. From January 2003, eight Haemophilia Centres (HC) RER began use computerized clinical records; every 6 months, they send data Parma Hospital be processed published a website ( http://www.registroemofiliarer.it ). Great efforts are made ensure high data. Results general interest included free ‘public area’ more sensitive...
Haemophilia A (HA) is an X-linked recessive bleeding disorder caused by a lack or decrease of coagulation factor VIII activity. The molecular diagnosis HA challenging and variety different mutations have been identified throughout the F8 gene. Our aim was to detect causative mutation in 266 patients from Emilia-Romagna region (Italy) all suspected carriers. Molecular analysis 201 (152 index cases) performed with combination several indirect direct approaches, such as long distance polymerase...
Regular physical activity can increase joint stability and function, reduce the risk of injury, improve quality life people with haemophilia (PwH). However, a recent review literature shows that appropriate sport are not always promoted enough in overall management PwH. A group Italian experts care undertook consensus procedure to provide practical guidance on when how recommend exercise programmes PwH clinical practice. Three main topics were identified-haemophilia its impact movement,...
Abstract Background: Laboratory investigation with specific factor XIII (FXIII) assays plays a crucial role in diagnosis of FXIII deficiency. According to the International Society on Thrombosis and Hemostasis (ISTH), it is necessary blank sample iodoacetamide, provided by kit or locally prepared, when ammonia release are used, avoid activity overestimation. Methods: In this study we set up modification Berichrom chromogenic assay, which iodoacetamide was added BCS analyzer reaction mixture...
The main aim of the research is to study how youths affected by haemophilia, a congenital hemorrhagic chronic disease, make sense their condition, with particular reference transition from early adolescence adulthood. We administered face-to-face semi-structured interviews 20 Italian aged 11–25 years, in on-demand treatment or prophylaxis therapy. A thematic analysis was performed help software for textual data figure out topics and role two selected variables emergence themes (age type...
Background In older people, multiple chronic ailments lead to the intake of medications (polypharmacy) that carry a number negative consequences (adverse events, prescription and errors, poor adherence, higher mortality). Because ageing patients with haemophilia (PWHs) may be particularly at risk due their pre‐existing comorbidities (arthropathy, liver disease), we chose analyse pattern drug in cohort PWHs aged 60 years or more. Patients methods S + PHERA is multicentre observational study,...
Haemophilias are X-linked inherited bleeding disorders, due to de novo F8/F9 gene variants in 30-50% of cases. The identification causative variant index cases (IC) is crucial for genetic counselling related women. Over the last 20 years Emilia-Romagna Regional Haemophilia Registry documented high proportions sporadic severe haemophilia.To clarify if carriers' reproductive choices influence sporadic/familial ratio haemophilia.Genetic and genotyping 221 relatives IC were retrospectively...