A5085540202- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hydrogen Storage and Materials
- Ammonia Synthesis and Nitrogen Reduction
- Orthopaedic implants and arthroplasty
- Nerve injury and regeneration
- Wound Healing and Treatments
- Boron and Carbon Nanomaterials Research
- Inorganic Chemistry and Materials
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Laser and Thermal Forming Techniques
- Total Knee Arthroplasty Outcomes
- Railway Engineering and Dynamics
- Iron and Steelmaking Processes
- Boron Compounds in Chemistry
- Vehicle Noise and Vibration Control
- Laser Material Processing Techniques
- Network Traffic and Congestion Control
- Energetic Materials and Combustion
- Collagen: Extraction and Characterization
Shenyang Institute of Automation
2015-2024
Chinese Academy of Sciences
2015-2024
University of Chinese Academy of Sciences
2023
Fudan University
2014-2018
Hunan University
2012-2014
Harbin Institute of Technology
2008-2012
Three-dimensional (3D) bioprinting combines biomaterials, cells and functional components into complex living tissues. Herein, we assembled function-control modules cell-laden scaffolds using 3D bioprinting. A customized printer was able to tune the microstructure of printed bone mesenchymal stem cell (BMSC)-laden methacrylamide gelatin at micrometer scale. For example, pore size adjusted 282 ± 32 μm 363 60 μm. To match requirements printing nozzle, collagen microfibers with a length 22 13...
Gelatin/sodium alginate/carboxymethyl chitosan hydrogel mixed with bone mesenchymal stem cells for 3D bioprinting.
Abstract Complicated vessels pervade almost all body tissues and influence the pathophysiology of human significantly. However, current fabrication strategies have limited success at multiscale vascular biofabrication. This study reports a methodology to fabricate soft vascularized tissue centimeter scale using multimaterial bioprinting by customized multistage‐temperature‐control printer. The printed constructs can be perfused via branched endothelialized vasculatures support well‐formed 3D...
As the essential foundation of bioprinting technology, cell-laden bio-ink is confronted with inevitable contradiction between printability and bioactivity. For example, type I collagen has been widely applied for its excellent biocompatibility; however, relatively low self-assembly speed restricts performance in high-precision structures. In this study, we synthesize norbornene-functionalized neutral soluble (NorCol) by reaction acid-soluble (Col) carbic anhydride aqueous phase. NorCol...
Abstract Engineered implantable functional thick tissues require hierarchical vasculatures within cell‐laden hydrogel that can mechanically withstand the shear stress from perfusion and facilitate angiogenesis for nutrient transfer. Yet current extrusion‐based 3D printing strategies are unable to recapitulate networks, highlighting need bioinks with tunable properties. Here, we introduce an approach whereby crosslinkable microgels enhance mechanical stability induce spontaneous microvascular...
Traditional tissue engineering skin are composed of living cells and natural or synthetic scaffold. Besize the time delay risk contamination involved with cell culture, lack autologous source persistence allogeneic in heterologous grafts have limited its application. This study shows a novel functional by carrying minimal unit (MFUS) 3D-printed polylactide-co-caprolactone (PLCL) scaffold collagen gel (PLCL + Col MFUS). MFUS is full-layer micro harvested from rat tail skin. PLCL elastic has...
Biochemical and physical guidance cues are both pivotal for axonal nerve regeneration. However, fabrication of a platform that can integrate biochemical gradients topographical remains challenging, especially in three-dimensional (3D) scaffold closely mimics vivo outgrowth conditions ready to be used repair. In this study, new method was introduced construct 3D scaffolds displaying continuous along longitudinally oriented microchannels by combining the modified printing directional freezing...
Bioprinting is a promising technology focusing on tissue manufacturing, whose vital problem the precise assembly of multiple materials. As primary solution, extrusion-based multi-printhead bioprinting (MPB) method requires printhead switching during printing process, which induces inefficient motion time and material interface defects. We present valve-based consecutive (VCB) to resolve these problems, containing integrated well-matched voxelated digital model. The rotary valve built-in VCB...
Biodegradable polycaprolactone/β-tricalcium phosphate (PT) composites are desirable candidates for bone tissue engineering applications. A higher β-tricalcium (TCP) ceramic content improves the mechanical, hydrophilic and osteogenic properties of PT scaffolds in vitro. Using a dynamic degradation reactor, we established steady vitro model to investigate changes physio-chemical biological during degradation.PT46 PT37 underwent more rapidly than with lower TCP contents. In vivo studies...
Owing to its crucial role in the human body, collagen has immense potential as a material for biofabrication of tissues and organs. However, highly refined fabrication using remains difficult, primarily because notably soft properties. A quantitative platform construct collagen-based peripheral nerve grafts, incorporating bionic structural chemical guidance cues, is introduced. viscoelastic model collagen, which facilitates simulating relaxation fabricating neural achieving maximum channel...
 With high precision, drop-on-demand, and noncontact material delivery advantages, inkjet bioprinting technology has been widely used in tissue manufacturing. However, the main challenge of is that bioink must be liquid-like printhead to avoid clogging nozzle, then form microdroplets, finally undergo crosslinking quickly a gel make an object with strength precision. The primary solution relies on fast sodium alginate by calcium chloride. Nevertheless, it difficult guarantee...
Nerve guidance conduits (NGCs) are an essential solution for peripheral nerve repair and regeneration in tissue engineering medicine. However, the ability of current NGCs is limited to repairing longer gap (i.e., >20 mm) because it cannot meet following two conditions simultaneously: (1) directional axial high-density channels (2) regenerative stimulation extracellular matrix secreted by Schwann cells (SCs). Therefore, we propose a multi-material 3D bioprinting process fabricate...
Abstract Fabricating connective tissue with printing fidelity, structural stability, biocompatibility, and cellular orientation remains a challenge for bioink. Collagen, as inherent fibers to provide strength in vivo , should be the ideal material printing. However, current collagen-bioink exhibits poor printability mechanical properties. Here, light-crosslinkable norbornene-collagen (NorCol) is developed solve this dilemma. NorCol complete collagen structure outstanding shear-thinning...
Collagen, one of the most biocompatible materials in nature, is widely used wound healing and organ repair. However, limited mechanical strength biological effectiveness collagen restrain its application as a hemostasis filling material medicine. To overcome these limitations, ultraporous collagen/oxidized regenerated cellulose (Col/ORC) composites were prepared. The results showed that Col-0.25%ORC composite had optimal wettability, porosity, water absorption. An MTT assay proved Col...
We report a strategy of using small cations to construct ionic liquid octahydrotriborate. The novel Li(NH3)B3H8, prepared by facile reaction NH4B3H8 with LiH, froze below -33.4 °C and crystallized into monoclinic unit cell lattice parameters = 8.813(1) Å, b 8.8626(1) c 8.2076(1) β 110.1046(5)°, providing promising functional octahydrotriborate the highest B3H8- content lowest freezing temperature.
An efficient synthesis of unsolvated KB3H8 was achieved by the reaction a liquid K-Na alloy with BH3·THF at room temperature. found to release hydrogen and minor boranes subsequent cleavage its B-H B-H-B bonds during pyrolysis, yield K2B12H12 as major product.
Three-dimensional (3D) printing has emerged as a transformative technology for tissue engineering, enabling the production of structures that closely emulate intricate architecture and mechanical properties native biological tissues. However, fabrication complex microstructures with high accuracy using biocompatible, degradable thermoplastic elastomers poses significant technical obstacles. This is primarily due to inherent soft-matter nature such materials, which complicates real-time...
Step-wise combination of NH3 with BH4(-) was found to proceed in the AlCl3·mNH3-nLiBH4 system. Firstly, only two N-H bonds groups combined B-H at low temperature. Secondly, residual could react further excess elevated This process is believed be a common feature for many metal borohydride ammoniates.
A series of novel hydrogen storage compounds (Al(BH<sub>4</sub>)<sub>3</sub>·<italic>n</italic>C<sub>2</sub>H<sub>8</sub>N<sub>2</sub>, <italic>n</italic> = 4, 3, 2, 1) were synthesized. This system turned out to be a reliable candidate.
During the past few decades, a variety of novel hydrogen-enriched boron–nitrogen–hydrogen (BNH) materials have been developed as prospective hydrogen storage candidates. Owing to their unique composition and properties, it has recently realized suggested that BNH may be potential solid propellants additives applied in hybrid rockets. Amine metal borohydride is system with promising properties. To investigate its propellant, combustion properties two newly ethylene diamine aluminum...
Laser forming is a highly flexible sheet metal technique. In laser along curved irradiation paths, the heated zone bigger and effects of processing parameters on deformation are complex. The behaviors ring metals have been investigated from thermal-mechanics analysis by finite element (FE) simulation based proposed method model. central angle scanning path were investigated. results as follows: (1) in comparison with bending linear path, marked third point has two peak temperatures during...