A5100336109- Barrier Structure and Function Studies
- Polysaccharides and Plant Cell Walls
- Proteins in Food Systems
- Advanced Glycation End Products research
- Protein Hydrolysis and Bioactive Peptides
- Polysaccharides Composition and Applications
- Flavonoids in Medical Research
- Aluminum toxicity and tolerance in plants and animals
- Phytochemicals and Antioxidant Activities
- Helicobacter pylori-related gastroenterology studies
- Macrophage Migration Inhibitory Factor
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Biosensors and Analytical Detection
- Saffron Plant Research Studies
- Advanced biosensing and bioanalysis techniques
- Magnesium in Health and Disease
- Gut microbiota and health
- Tea Polyphenols and Effects
- Connective tissue disorders research
- Transcranial Magnetic Stimulation Studies
- Chronic Kidney Disease and Diabetes
- Phytochemistry and Biological Activities
- Extracellular vesicles in disease
- Food composition and properties
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Guangdong University of Petrochemical Technology
2020-2025
China National Center for Food Safety Risk Assessment
2022
Huazhong Agricultural University
2022
Anhui University of Traditional Chinese Medicine
2019
Capital Medical University
2018
Zhejiang University
2016
Shaanxi Research Association for Women and Family
2010
Whether changes in endothelial tight junctions (TJs) lead to the formation of thoracic aortic aneurysm and dissection (TAAD) serve as an early indicator therapeutic target remains elusive.Single-cell RNA sequencing analysis showed aberrant TJ expressions aortas patients with TAAD. In a β-aminopropionitrile (BAPN)-induced TAAD mouse model, function was disrupted at stage (5 10 days) observed by vascular permeability assay, while intercellular distribution crucial components significantly...
The pathogenesis of thoracic aortic aneurysm (TAA) in Marfan syndrome (MFS) is generally attributed to vascular smooth muscle cell (VSMC) pathologies. However, the role immune cell-mediated inflammation remains elusive. Single-cell RNA sequencing identified a subset CX3CR1+ macrophages mainly located intima roots and ascending aortas Fbn1C1041G/+ mice, further validated MFS patients. Specific elimination cells by diphtheria toxin Cx3cr1-CreERT2iDTRF/+Fbn1C1041G/+ mice efficiently ameliorated...
Abstract BACKGROUND Tea dregs, typically generated during the production of instant tea or beverages, have conventionally been regarded as waste material and routinely discarded. Nevertheless, contemporary research endeavors are concentrating on discovering efficient methods for utilizing potential this discarded resource. RESULTS In study, we employed a sequential extraction method using chemical chelating agents to extract isolate four distinct cell wall polysaccharides, designated CWTPS‐1...
This study investigated the structural characteristics and hypoglycemic activity of polysaccharides isolated from Ganpu tea (GPT) in different storage periods. Three polysaccharide fractions (GPTPS1-E2, GPTPS3-E2, GPTPS5-E2, representing 1, 3, 5 years storage, respectively, where GPTPS is polysaccharides) were extracted purified GPT. Chemical composition analysis revealed that all predominantly acidic with total sugar content exceeding 90%. Monosaccharide showed galacturonic acid as primary...
The present study was aimed at investigating whether dietary anemonin could alleviate LPS-induced intestinal injury and improve barrier restoration in a piglet model. Eighteen 35-d-old pigs were randomly assigned to three treatment groups (control, LPS LPS+anemonin). control fed basal diet, the + group received diet 100 mg anemonin/kg diet. After 21 d of feeding, LPS- anemonin-treated piglets i.p. administration LPS; saline. At 4 h post-injection, jejunum samples collected. results showed...
The aims of the present study were to investigate anti-inflammatory function two flavonoids apigenin and genistein in rat intestinal epithelial (IEC-6) cells stimulated by tumor necrosis factor-alpha (TNF-α) clarify whether heat treatment might affect flavonoid activity. at lower dosage (e.g. 5 μmol/L) had no toxic effect but growth promotion on cells. Meanwhile, pretreatment before TNF-α stimulation could maintain cellular morphology, decrease production prostaglandin E2 pro-inflammatory...
Biosensors for mercury (II) (Hg2+) with high sensitivity are urgently required food safety, ecosystem protection and disease prevention. In this study, a simple fast detection method of Hg2+ based on the molecular beacon aptamer was established, according to principle that could change structure aptamer, resulting in changed fluorescence intensity. All conditions were optimized. It found an optimal MB3 showed response signal optimized reaction environment, which 0.08 μmol/L MB3, 50 mmol/L...
The soluble and non-digestible longan (Dimocarpus Lour.) polysaccharides (LP) with Se content less than 0.01 g/kg were extracted selenylated chemically the HNO3-Na2SeO3 system, to prepare two products namely SeLP1 SeLP2 enhanced contents of 1.46 4.79 g/kg, respectively. LP, SeLP1, then measured compared for their saccharide features bioactivity in human colon carcinoma HCT-116 cells. Compared both contained more neutral saccharides, but showed reduced uronic acid undetectable sulfate....
In this study, milk protein casein was glycated by oligochitosan through the catalysis of transglutaminase (TGase) and then hydrolyzed trypsin. The obtained hydrolysates (GCNH) were assessed for their anti-inflammatory activities, using lipopolysaccharide (LPS)-stimulated rat intestinal epithelial cells (IEC-6) as cell models (CNH) without TGase controls. results showed that GCNH had incorporation thus possessed a glucosamine content 5.74 g/kg protein. general, at dose levels 25-100 μg/mL...
The anti-cancer effects of selenylated plant polysaccharides are a focus research. As natural with extensive biological effects, there have been few studies related to edible purslane (Portulaca oleracea L.). Thus, in this study, soluble P. (PPS) were extracted from the dried and then chemically using HNO3-Na2SeO3 method obtain two products, namely, SePPS1 SePPS2. Compared PPS, SePPS2 had much higher Se contents (840.3 1770.5 versus 66.0 mg/kg) while also showing lower three...
To observe the effects of a traditional Chinese medicine (TCM) capsule for replenishing qi, nourishing yin and activating blood on Notch/Hes1 signaling pathway in renal tissue vascular endothelial CD34 CD144 expressions rat model diabetic nephropathy.Rat models early-stage nephropathy were established by left nephrectomy high- fat sugar feeding combined with intraperitoneal injection STZ. The rats randomized into group, benazepril high-, moderate-, low-dose TCM groups corresponding...