A5100363705- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Genomics, phytochemicals, and oxidative stress
- Galectins and Cancer Biology
- Digestive system and related health
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Mast cells and histamine
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- Retinal Diseases and Treatments
- Medicinal plant effects and applications
- Phytochemical and Pharmacological Studies
- Gut microbiota and health
- Diet and metabolism studies
- DNA and Nucleic Acid Chemistry
- Pancreatic and Hepatic Oncology Research
- Blood groups and transfusion
- Glaucoma and retinal disorders
- Adenosine and Purinergic Signaling
- Synthesis and biological activity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Hydrolysis and Bioactive Peptides
Korea University
2006-2024
National Cancer Institute
2008-2023
Soonchunhyang University
2015-2020
National Institutes of Health
1989-2020
Eulji University
2020
Pennsylvania State University
2005-2018
Center for Cancer Research
2007-2017
City Of Hope National Medical Center
2005-2017
Soonchunhyang University Hospital
2015-2017
University of Florida
2017
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, commercially available probiotic supplement use melanoma patients performed parallel preclinical studies. Higher fiber was associated with significantly improved progression-free survival 128 ICB, most pronounced benefit observed sufficient intake no use. Findings were...
ABSTRACT Mucin expression was analysed, in relation to cell growth, parental HT-29 cells and two populations of mucus-secreting selected by adaptation methotrexate (HT29-MTX) or 5-fluorouracil (HT29-FU). These express mature mucins that differ their immunoreactivity antibodies against gastric colonic In the population, at late confluency, only very few produce MUC1 glycoprotein, this being consistent with low level mRNAs corresponding MUC5C mucin genes. HT29-MTX HT29-FU populations,...
Sodium butyrate and dimethylsulfoxide (DMSO) have marked effects on the growth, morphology, biochemistry of two human colonic adenocarcinoma cell lines in culture. Doubling times were increased between 18% 660% while viability was unaffected. Both formed colonies soft agar absence DMSO, but no observed presence these agents. However, differences vivo tumorigenicities, when cells implanted athymic mice, seen following treatment. Gross morphological alterations including enlargement, process...
Membrane glycopeptides were examined in human colonic adenocarcinoma and normal mucosa. The carbohydrates of membrane found to be markedly reduced tumor tissue the relative proportions various sugars altered. Although all lower when compared adjacent mucosa, galactosamine, fucose, sialic acid more significantly reduced. Examination blood group activity lectin-binding properties revealed that specific carbohydrate structures had changed tissue. Most striking these changes was disappearance...
Sporadic and non-hereditary mutations account for the majority of colorectal cancers (CRC). After loss adenomatous polyposis coli (APC) function activation β-catenin/LEF signaling pathway, activating in Kras are major drivers sporadic CRC. Preventing outgrowth cells that develop will decrease Resveratrol, a naturally occurring polyphenolic compound has anti-inflammatory, anti-oxidant anti-cancer activities. We used genetically engineered mouse model CRC where APC locus is knocked out...
Triple-negative breast cancer (TNBC) represents the poorest prognosis among all of subtypes with no currently available effective therapy. In this study, we hypothesized that sulforaphane, a dietary component abundant in broccoli and its sprouts, can inhibit malignant cell proliferation tumor sphere formation stem-like cells (CSC) TNBC. CSC population was isolated using FACS analysis combined stem surface markers, CD44+/CD24-/CD49f+ The effect sulforaphane on stem-related embryonic oncogene...
Human colon cancer is associated with antigenic and structural changes in mucin-type carbohydrate chains (O-glycans). To elucidate the control of biosynthesis these O-glycans cancer, we have studied glycosyltransferase sulphotransferase activities involved assembly elongated O-glycan structures. We analysed homogenates prepared from tissue, adjacent normal distal tissue 20 patients. Several transferase showed pronounced tissue. The correlate previous findings a loss mucins, but did not...
Abstract Purpose: The relationship between global hypomethylation, chromosomal instability (CIN), and microsatellite (MSI) remains unclear in colorectal cancer. aim of this study was to investigate the methylation status, loss heterozygosity (LOH), MSI sporadic Experimental Design: We determined levels 80 cancers, 51 adjacent normal tissues, 20 tissues using long interspersed nucleotide elements–combined bisulfite restriction analysis method. also analyzed cancers for status LOH at...
Recent evidence suggests tumor-initating cells (TICs), also called cancer stem cells, are responsible for tumor initiation and progression; therefore, they represent an important cell population development of future anti-cancer therapies. In this study, we show that the sesquiterpene lactone parthenolide (PTL) is cytotoxic to prostate TICs isolated from lines: DU145, PC3, VCAP, LAPC4, as well primary TICs. Furthermore, PTL inhibited TIC-driven formation in mouse xenografts. Using integrated...
Analysis of the Polyp Prevention Trial showed an association between isorhamnetin-rich diet and a reduced risk advanced adenoma recurrence; however, mechanism behind chemoprotective effects isorhamnetin remains unclear. Here, we show that prevents colorectal tumorigenesis FVB/N mice treated with chemical carcinogen azoxymethane subsequently exposed to colonic irritant dextran sodium sulfate (DSS). Dietary decreased mortality, tumor number, burden by 62%, 35%, 59%, respectively. MRI,...
Transforming growth factor-β (TGF-β) and related factors are multifunctional cytokines that regulate diverse cellular processes, including proliferation, differentiation, apoptosis, immune response. The involvement of TGF-β receptor-mediated signaling in bacteria-induced up-regulation mucin, a primary innate defensive response for mammalian airways, however, still remains unknown. Here, we report the bacterium nontypeable<i>Haemophilus influenzae</i> (NTHi), an important human respiratory...