A5102794749- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Acute Myocardial Infarction Research
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
- Atrial Fibrillation Management and Outcomes
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Metabolism and Genetic Disorders
- Autophagy in Disease and Therapy
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Adenosine and Purinergic Signaling
- RNA modifications and cancer
- Cardiac Valve Diseases and Treatments
- Kawasaki Disease and Coronary Complications
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Chemotherapy-induced cardiotoxicity and mitigation
- Gout, Hyperuricemia, Uric Acid
Guangxi University of Chinese Medicine
2025
Fudan University
2016-2024
The First Affiliated Hospital, Sun Yat-sen University
2016-2024
Zhongshan Hospital
2016-2024
Shanghai Clinical Research Center
2021-2024
Sun Yat-sen University
2016-2024
Shanghai Institute of Hematology
2017-2024
National Clinical Research
2022-2023
Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects against endothelial dysfunction, mitochondrial and DCM; however, its effects on mitophagy remain unexplored. The present study aimed to assess the beneficial of nicorandil DCM underlying mechanisms. Cardiac perfusion was assessed using a lectin assay, while via mt-Keima transfection transmission electron microscopy....
Current evidence indicates that coronary microcirculation is a key target for protecting against cardiac ischemia-reperfusion (I/R) injury. Mitochondrial calcium uniporter (MCU) complex activation and mitochondrial ([Ca2+]m) overload are underlying mechanisms involved in cardiovascular disease. Histidine triad nucleotide-binding 2 (HINT2) has been reported to modulate [Ca2+]m via the MCU complex, our previous work demonstrated HINT2 improved cardiomyocyte survival preserved heart function...
Abstract Aim To explore the beneficial effects of L‐carnitine on cardiac microvascular dysfunction in diabetic cardiomyopathy from perspectives mitophagy and mitochondrial integrity. Methods Male db/db db/m mice were randomly assigned to groups treated with or a solvent for 24 weeks. Endothelium‐specific PARL overexpression was attained via adeno‐associated virus serotype 9 (AAV9) transfection. Adenovirus (ADV) vectors overexpressing wild‐type CPT1a, mutant transfected into endothelial cells...
Doxorubicin (DOX) as a chemotherapeutic agent can cause mitochondrial dysfunction and heart failure. COX5A has been described an important regulator of energy metabolism. We investigate the roles in DOX-induced cardiomyopathy explore underlying mechanisms. C57BL/6J mice H9c2 cardiomyoblasts were treated with DOX, expression was assessed. An adeno-associated virus serum type 9 (AAV9) lenti-virus system used to upregulate expression. Echocardiographic parameters, morphological histological...
Abstract Calcium overload is the key trigger in cardiac microvascular ischemia–reperfusion (I/R) injury, and calreticulin (CRT) a calcium buffering protein located endoplasmic reticulum (ER). Additionally, role of pinacidil, an antihypertensive drug, protecting microcirculation against I/R injury has not been investigated. Hence, this study aimed to explore benefits pinacidil on with focus endothelial homeostasis CRT signaling. Cardiac vascular perfusion no-reflow area were assessed using...
Abstract Coronary microembolization (CME), a common reason for periprocedural myocardial infarction (PMI), bears very important prognostic implications. However, the molecular mechanisms related to CME remain largely elusive. Statins have been shown prevent PMI, but underlying mechanism has not identified. Here, we examine whether NLRP3 inflammasome contributes CME-induced cardiac injury and investigate effects of statin therapy on CME. In vivo study, mice with were treated 40 mg/kg/d...
Abstract Background Indobufen is widely used in patients with aspirin intolerance East Asia. The OPTION trial launched by our cardiac center examined the performance of indobufen based dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). However, vast majority acute syndrome (ACS) and were excluded. We aimed to explore this question a real-world population. Methods Patients enrolled ASPIRATION registry grouped according DAPT strategy that they received PCI....
Brain ischemia disrupts endoplasmic reticulum (ER) dynamics, causes ER stress, and triggers the unfolded protein response (UPR). During UPR, kinase RNA-like (PERK) phosphorylates eIF2α, shutting down global synthesis, inhibits provides neuroprotection during acute ischemic stroke. Herein, middle cerebral artery occlusion/reperfusion (MCAO/R) PERK neuron-specific deletion conditional knockout mice were employed to observe function mechanisms of PERK. CCT020312, a novel selective activator,...
Heart failure is a worldwide pandemic with an unacceptable high level of morbidity and mortality. Understanding the different pathophysiological mechanisms will contribute to prevention individualized therapy heart failure. We established mouse models for ischemic cardiomyopathy (ICM) dilated (DCM) by inducing myocardial infarction Coxsackievirus B3 infection respectively. Isobaric tags relative absolute quantitation liquid chromatography coupled tandem mass spectrometry technology was used...
The internal thoracic artery (ITA) that differs from coronary (CA), rarely develops atherosclerosis. Understanding the mechanism underlying such a difference will help to pave new way prevention and treatment of disease. We hypothesize herein in susceptibility atherosclerosis between CA ITA is attributable heterogeneity perivascular adipose tissues (PVATs) surrounding these two kinds arteries, i.e. PVAT-CA PVAT-ITA. isolated PVAT eight patients heart disease (CHD) four non-CHD patients. Gene...
Gut microbiota community shift with coronary artery disease (CAD) has been reported in several limited cohorts during the past years. However, whether enriched or decreased taxa CAD can be reproducible deserves further investigation and validation. In this study, 78 human subjects were recruited. Of these, 19 diagnosed without stenosis (control group, referred to herein as Ctrl), 14 less than 50% (LT50), 45 greater (GT50). Fecal samples collected DNA was extracted perform 16S ribosomal RNA...
Abstract Background Angiographic no‐reflow is associated with poor outcomes in patients ST‐segment elevation myocardial infarction (STEMI). We sought to develop and validate a score system predict angiographic primary percutaneous coronary intervention (PCI). Methods undergoing PCI were consecutively enrolled randomly divided into the training validation set. was defined as thrombolysis (TIMI) flow grade 0 2 after PCI. In set, independent predictors identified by logistic regression...
The perturbation of fatty acid metabolism in heart failure (HF) has been a critical issue. It is unclear whether the amounts circulating carnitines will benefit primary etiology diagnosis and prognostic prediction HF. This study was designed to assess diagnostic values serum carnitine profiles between ischemic non-ischemic derived failure.HF patients (non-ischemic dilated cardiomyopathy: DCM-HF, n = 98; disease: IHD-HF, 63) control individuals (n 48) were enrolled consecutively....
To explore the role of histidine triad nucleotide-binding 2 (HINT2) protein in heart failure. Neonatal mouse ventricle myocytes (NMVMs) and myocardial infarction-induced failure mice were used for vitro or vivo experiments. Adenovirus (ADV) adeno-associated virus serum type 9 (AAV9) vectors to regulate HINT2 expression. The expression was determined by quantifying mRNA levels. Cell survival analysed using CCK-8 kit TUNEL staining. Mitochondrial function mitochondrial membrane potential...
Coronary microembolization (CME) is an important clinical problem and it related to poor outcome. The specific molecular mechanisms of CME are not fully understood. In the present study, we established a mice model CME. Isobaric tags for relative absolute quantitation (iTRAQ) liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) technologies identified 249 differentially expressed proteins in myocardial tissues as compared sham-operated mice. Bioinformatics analysis...
Abstract Dilated cardiomyopathy (DCM), as characterized by the left ventricular dilatation and contractile dysfunction, is one of molecular mechanisms which are largely unexplored. Here, we profiled region‐resolved transcriptome proteome healthy DCM human myocardial tissue obtained deep‐coverage dataset consisting 7,605 proteins 19,880 transcripts in four chambers heart. On basis core characters hearts, chamber‐specific alterations were further revealed end‐stage DCM, among extracellular...
Predictors of prognosis in patients with coronary chronic total occlusion (CTO) undergoing elective percutaneous intervention (PCI) have remained lacking. Lipidomic profiling enables researchers to associate lipid species disease progression and may improve the prediction cardiovascular events.