A5071213317- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Medical Image Segmentation Techniques
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Luminescence Properties of Advanced Materials
- Nuclear Physics and Applications
- Nanoplatforms for cancer theranostics
- 3D Shape Modeling and Analysis
- Photodynamic Therapy Research Studies
- Advanced Vision and Imaging
- Radiation Therapy and Dosimetry
- Computer Graphics and Visualization Techniques
- Neuroscience and Neural Engineering
- Medical Imaging and Analysis
- Ion channel regulation and function
- Click Chemistry and Applications
- Cardiac Imaging and Diagnostics
- Advanced Radiotherapy Techniques
- Nicotinic Acetylcholine Receptors Study
- Particle Detector Development and Performance
- Radiomics and Machine Learning in Medical Imaging
- Vanadium and Halogenation Chemistry
- RNA Interference and Gene Delivery
University of Chicago
2010-2024
University of Illinois Chicago
1996-2021
National Health Research Institutes
2005-2010
University of Chicago Medical Center
2010
Franklin Institute
1987-1990
Abstract The characterization of near‐infrared (NIR) mesoporous silica nanoparticles (MSN) suitable for in vivo optical imaging with high efficiency is presented. Trimethylammonium groups modified MSN (MSN‐TA) the average size 50–100 nm was synthesized incorporation TA into framework MSN. It further adsorbed indocyanine green (ICG) by electrostatic attraction to render MSN‐TA‐ICG as an efficient NIR contrast agent imaging. studies stability against pH indicated bonding stable over range from...
The segmentation and three‐dimensional representation of the liver from a computed tomography (CT) scan is an important step in many medical applications, such as surgical planning for living‐donor transplant automatic detection documentation pathological states. A method being developed to automatically extract structure abdominal CT scans using priori information about morphology digital image‐processing techniques. Segmentation performed sequentially image‐by‐image (slice‐by‐slice),...
A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the conjugates provide a delayed drug-releasing mechanism allow NSC migration towards distant tumor site; 3) eventually undergo cell death release impregnated MSN-Dox, which subsequently induces toxicity surrounding glioma cells.
Purpose The accurate segmentation of liver and tumors from CT images can assist radiologists in decision‐making treatment planning. contours are currently obtained by manual labeling, which is time‐consuming subjective. Computer‐aided methods have been widely used the tumors. However, due to diversity shape, volume, image intensity, still a difficult task. In this study, we present Spatial Feature Fusion Convolutional Network (SFF‐Net) automatically segment images. Methods First, extract...
Reports on a new method in which spatially correlated magnetic resonance (MR) or X-ray computed tomography (CT) images are employed as source of prior information the Bayesian reconstruction positron emission (PET) images. This incorporates structural anatomic templates can be used for extracting about boundaries that separate regions exhibiting different tissue characteristics. In order to avoid possible introduction artifacts caused by discrepancies between functional and boundaries,...
A recent trend in PET instrumentation is the use of silicon photomultipliers (SiPMs) for high resolution and time-of-flight (TOF) detection. Due to its small size, a system can large number SiPMs hence effective scalable multiplexing readout methods become important. Unfortunately, generally degrades fast timing properties necessary TOF, especially at channel reduction. Previously, we developed stripline (SL)-based method that uses time-based mechanism. This maintains by design has been...
Cone‐beam microcomputed tomography (microCT) is one of the most popular choices for small animal imaging which becoming an important tool studying models with transplanted diseases. Region‐of‐interest (ROI) techniques in CT, can reconstruct ROI image from projection data set ROI, be used not only reducing imaging‐radiation exposure to subject and scatters detector but also potentially increasing spatial resolution reconstructed images. Increasing microCT images facilitate improved accuracy...
Abstract Herein, we report the development of an 18 F‐labeled, activity‐based small‐molecule probe targeting cancer‐associated serine hydrolase NCEH1. We undertook a focused medicinal chemistry campaign to simultaneously preserve potent and specific NCEH1 labeling in live cells animals, while permitting facile F radionuclide incorporation required for PET imaging. The resulting molecule, [ F]JW199, labels active at nanomolar concentrations greater than 1000‐fold selectivity relative other...
Traditional photodynamic therapy (PDT), a clinical cancer therapeutic approach using light in killing cells, is often limited by insufficient penetration, inefficient photosensitizer energy transfer, and inadequate oxygen hypoxic tumors. Employing X-ray to activate PDT can potentially overcome these limitations. Here, we compared protocols synthesize novel nano-photosensitizer composed of europium-doped yttrium oxide core with silica shell (Y2O3:Eu@SiO2) which be utilized such method, i.e.,...
Traditional photodynamic therapy (PDT) is often limited in its efficacy by insufficient light penetration, inefficient photosensitizer energy transfer, and inadequate target tissue oxygenation. X-ray activated PDT (XPDT), using nanoparticle (NPs) photosensitizers comprised of europium-doped yttrium oxide cores encased within silica shells (Y2O3:Eu@SiO2), offers the potential overcoming most these limitations. Aimed at maximizing generation reactive oxygen species (ROS), this study reports...
The expectation maximization (EM) algorithm has received considerable attention in the area of positron emitted tomography (PET) as a restoration and reconstruction technique. In this paper, capabilities EM when applied to radiographic images is investigated. This application does not involve reconstruction. performance quantitatively evaluated using “perceived” signal‐to‐noise ratio (SNR) image quality metric. perceived SNR based on statistical decision theory includes both observer's...
In this preliminary study, a procedure for synthesizing novel PET radiotracer vanadium-48-labeled-vanadyl acetylacetonate was developed, including radioisotope production via cyclotron, separation of 48V, chelation as 48VO(acac)2, and assessment through in vitro cellular studies. We employed the beam-stop setup cyclotron target holder to irradiate titanium foils reaction natTi (p,n)48V. The rate 4.84 ± 0.67 μCi/μA-h. Overall radiochemical yield 12.86 0.51% with gamma-ray spectroscopy showing...
Abstract When compared with the many tamoxifen‐activated Cre mouse lines available for gene manipulation studies, relatively few RU486‐inducible mice are in use, due to leakiness issues. Here, we report generation of an triple fusion (GCrePR1e), consisting green fluorescent protein, Cre, and progesterone receptor ligand‐binding domain (F642‐L901). We sought improve GCrePR1e by selecting a truncated human lactoferrin (Lf) promoter drive its expression, based on promoter's low basal activity...
An all-digital positron emission tomography (PET) scanner for imaging small animals has been developed at Huazhong University of Science and Technology (HUST). The implementation block detector with position sensitive photomultiplier (PSPMT) multi-voltage threshold (MVT) technology is presented in this paper. comprises 12 basic modules (BDMs), which can be used to construct various types PET architecture due the modularized design. Each BDM composed a unit (DU) digital processing (DPU)....
In a recent study, we proposed sophisticated data-processing technique for correcting parallax errors that believe allows different, more efficient, and cost-effective design strategies. particular, demonstrated with conceptual the general feasibility of adopting this approach construction compact positron emission tomography (PET) systems. our design, employed new-generation depth-of-interaction detectors in circular, highly PET system to generate imperfect, but redundant, data. The...
We propose a new electronic design to overcome limitations in PET that arise from the need use high-cost fast analog-to-digital converters (ADCs). Our may completely remove of ADCs PET, and possibly constant fraction discriminator (CFD) as well. In our approach, we model electric pulse generated upon an event detection by linearly rising edge followed slower exponential decay. Based on this modeling, basic properties are relevant for detection, including decay constant, peak value time, can...
X-ray-induced luminescence (XIL) is a hybrid x-ray/optical imaging modality that employs nanophosphors in response to x-ray irradiation. X-ray-activated phosphorescent nanoparticles have potential applications radiation therapy as theranostics, nanodosimeters, or radiosensitizers. Extracting clinically relevant information from the luminescent signal requires development of robust model can determine nanophosphor distributions at depth an optically scattering environment surface radiance...
We report the design and experimental validation of a compact positron emission tomography (PET) detector module (DM) intended for building preclinical PET electron-paramagnetic-resonance-imaging hybrid system that supports sub-millimeter image resolution high-sensitivity, whole-body animal imaging. The DM is eight units (DU) in row. Each DU contains 12×12 lutetium-yttrium oxyorthosilicate (LYSO) crystals having 1.05 mm pitch read by 4×4 silicon photomultipliers (SiPM) 3.2 pitch. A...
Sinogram restoration followed by filtered backprojection (FBP) is a fast method for obtaining PET images of good quality and quantitative accuracy. In previous studies, the authors used detector motion projection onto convex sets sinogram to improve on FBP reconstruction; but, performance was observed degrade rapidly when noise level data increased. this paper, describe based Kalman filtering that provides promising results in computer simulations. The potential benefits new includes...
The multi-pixel photon counter (MPPC), also known as the silicon photo-multiplier (SiPM), is a novel, solid-state photodetector that contains an array of Geiger-mode photodiodes (called microcells below) to gain in range 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> -10 xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> when operating at low voltage 40-70 V. device has relatively high detection efficiency (PDE) and fast timing...
In this work, we will report solid evidences supporting the proposed compact, dual-head PET scanner design for achieving an unprecedented sensitivity. We also our initial imaging results generated by prototypical with phantoms and rats.
Proposes an approach applying artificial neural net techniques to 3D rigid motion analysis based on sequential multiple time frames. The consists of two phases: (1) matching between every consecutive frames and (2) estimating parameters the correspondences established. Phase 1 specifies constraints ensure a stable coherent feature correspondence establishment configures 2D Hopfield enforce these constraints. 2 constructs 3-layer estimate through supervised learning. method performs It...