A5070717046- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Circular RNAs in diseases
- Medicinal Plant Pharmacodynamics Research
- Neurological Disorders and Treatments
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- Technology Assessment and Management
- Pharmacological Effects of Natural Compounds
- Tissue Engineering and Regenerative Medicine
- Nerve injury and regeneration
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Anesthesia and Neurotoxicity Research
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Hydrogen's biological and therapeutic effects
- Cytokine Signaling Pathways and Interactions
- Medical Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
Fourth Affiliated Hospital of China Medical University
2005-2021
China Medical University
2008-2021
Shenyang University of Technology
2007
Cerebral ischemia/reperfusion injury (CIRI) leads to in distant organs, most commonly the lungs, although limited studies have examined self-protective mechanisms during CIRI-induced lung injury. Here, we investigated that attenuate stress-related and promote angiogenetic repair of epithelial function by measuring nuclear factor erythroid-related 2 (Nrf2) hypoxia-inducible factor-1α (HIF-1α) levels. A CIRI model was established male Sprague-Dawley rats blocking middle cerebral artery. Rats...
Ischemic stroke is known as a neurodegenerative disorder, which induces long-period tissue damage. Chemokine (C-X-C motif) ligand 8 (CXCL8) involved in acute inflammation and tumor progression through the phosphoinositide-3-kinase/protein kinase B/nuclear factor-κB (PI3K/Akt/NF-κB)-signaling pathway. In this study, we aimed to explore mechanism of CXCL8 ischemic relation PI3K/Akt/NF-κB-signaling pathway.Microarray-based gene expression profiling peripheral blood mononuclear cells was used...
Ischemic stroke (IS), which is characterized by high morbidity, disability, and mortality, recognized as a major cerebrovascular disease. MicroRNA-31 (miR-31) was reported to participate in the progression of brain The present study conducted order investigate effect miR-31 on oxidative stress-induced neuronal injury IS mice with involvement protein kinase D1 (PKD1) JAK/STAT3 pathway. C57BL/6J were used establish middle cerebral artery occlusion (MCAO) model. Astrocytes transfected mimic,...
Serenoa repens, the extract of berry in Southeastern United States, is one several phytotherapeutic agents available for treatment Benign prostatic hyperplasia (BPH). In this study, we found first time that repens effectively inhibited growth human U87 and U251 glioma cells. Flow cytometry assay showed induced apoptosis cells a dose-dependent manner. Also, increased expression cleaved-PARP, Caspase-3 or p27 protein these two cell lines, respectively. addition, down-regulated basal level...
Signal transducer and activator of transcription factor 3 (STAT3) plays an important role in the proliferation angiogenesis human glioma. Previous research indicated that saw palmetto extract markedly inhibited glioma cells through STAT3 signal pathway. But its effect on tumor metastasis antiangiogenesis is not clear. This study to further clear impact cell metastasis, antiangiogenesis, mechanism. TUNEL assay apoptotic treated group are higher than control (<mml:math...
Ischemic stroke, caused by the blockage of blood supply, is a major cause death worldwide. For identifying potential candidates, we explored effects microRNA‐150 (miR‐150) has on ischemic stroke and its underlying mechanism developing stable middle cerebral artery occlusion (MCAO) rat model. Gene expression microarray analysis was performed to screen differentially expressed genes associated with MCAO. We evaluated miR‐150 Mal status ERK1/2 axis in brain tissues MCAO rats. Then cortical...
Saw palmetto extract can induce the apoptosis of prostate cancer cells. The aim present study was to investigate effect saw on phosphatidylinositol 3-kinase (PI3K)/Akt signaling transduction pathway in human glioma U87 and U251 cell lines. Suspensions cells a logarithmic growth phase were seeded into six-well plates at density 104 cells/well. In experimental group, 1 μl/ml added, while control group cultured without drug for 24 h. expression levels PI3K, B-cell lymphoma-extra large (Bcl-xL)...
Sonchus oleraceus is a kind of medicinal and edible plant which widely distributed. In this study, two new sesquiterpenes 1 2 along with three known compounds 3-5 were isolated from by the methods column chromatography. The structures novel constructed on basis HR-MS NMR spectra. Cytotoxicities assayed EOMA cell lines exhibited no inhibitory effect while elicited moderate cells IC50 value 26.5 μM. Western Blot assay indicated that could suppress proliferation inducing apoptosis through...
The majority of patients that suffer a stroke have excessive sputum, which accelerates the development pulmonary complications. However, it is unclear whether cerebral ischemia and reperfusion (I/R) injury induces mucus hypersecretion, potential role inflammation remains unknown. In present study, reversible middle artery occlusion model was applied in rats to induce I/R injury. were grouped according duration (6, 12, 24, 48 72 h). Neurological dysfunction evaluated by Longa scoring lung...
Objective To investigate the effect of saw palmetto extract (SR) on GL261 glioma in rats and immune system. Methods The 40 were divided into 4 groups randomly, one was control group without tumor (n=10), other 30 given subcutaneous inoculation cells then 3 groups: tumor-bearing low dose SR high (n=10). After 1 weeks feeded, extract, 50 mg/kg once a day every 300 day. The received same distilled water. feeding, we measured weight inhibition rate calculated. cell apoptosis detected by...