A5101724849- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Nerve injury and regeneration
- Hip disorders and treatments
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Bone fractures and treatments
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Neurogenesis and neuroplasticity mechanisms
- Hip and Femur Fractures
- Tendon Structure and Treatment
- Dental Implant Techniques and Outcomes
- Advanced materials and composites
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Tribology and Wear Analysis
- Titanium Alloys Microstructure and Properties
- Selenium in Biological Systems
- Electrospun Nanofibers in Biomedical Applications
- Ovarian function and disorders
- Kruppel-like factors research
University College London
2006-2024
Ningxia Medical University
2011-2024
Columbia University
2024
Flinders University
2024
Stanmore College
1994-2021
Pennsylvania State University
2020-2021
Northwick Park Institute for Medical Research
2021
Middlesex University
2015-2021
Royal National Orthopaedic Hospital
1999-2017
Middlesex University
2014
ABSTRACT Widespread concern exists about adverse tissue reactions after metal‐on‐metal (MoM) total hip replacement (THR). Concerns have also been expressed with wear and corrosion of taper junctions in THR. We report the effect surface finish contact area associated a single combination materials modular tapers. In an vitro test, we investigated head/neck (CoCrMo/Ti) interface THRs using commercially available heads. Wear surfaces was compared following 10 million loading cycle. Surface...
We report the theoretical basis of a method to measure axial migration femoral components total hip replacements (THR). The use top greater trochanter and lateral point on collar stem, allowing for variations up 10 degrees rotation femur in any direction between successive radiographs, gave maximum error 0.37 mm. At more realistic 5 rotational variation, was only 0.13 These data were confirmed an experimental study using digitisation points special software. also showed that centre head,...
Mesenchymal stem cells have become a very attractive source of cell implantation for neural tissue engineering. The ideal transplantation should be easily obtained, and rapidly proliferate in vitro low immunogenicity. purpose this study was to investigate the regenerative potential adipose-derived (ADSC) on peripheral nerve repair. ADSCs were isolated from rat adipose cultured until adherent became morphologically homogeneous with fibroblast-like shape, transplanted acellular allografts...
Recent evidence suggests that the implantation of bone marrow-derived mesenchymal stem cells improves peripheral nerve regeneration. In this study we aimed to investigate whether adipose-derived (ADSCs) can be used for repair.In a rat model, regeneration was evaluated across 15 mm lesion in sciatic by using an acellular injected with allogenic ADSCs. The walking behaviour rats measured footprint analysis, and electrophysiological analysis histological examination were performed evaluate...
Acellular nerves possess the structural and biochemical features similar to those of naive endoneurial tubes, have been proved bioactive for allogeneil graft in nerve tissue engineering. However, source allogenic donators is restricted clinical treatment. To explore sufficient substitutes acellular allografts (ANA), we investigated effectiveness xenografts (ANX) combined with bone marrow stromal cells (BMSCs) on repairing peripheral injuries. The derived from Sprague-Dawley rats New Zealand...
Treatment of critical size bone defects pose a challenge in orthopedics. Stem cell therapy together with cytokines has the potential to improve repair as they cause migration and homing stem cells defect site. However, engraftment, participation, recruitment other within regenerating tissue are important. To enhance involvement, this study investigated overexpression stromal cell-derived factor 1 (SDF-1) using an adenovirus. We hypothesized that these engineered would effectively increase...
Titanium and its alloys or tantalum (Ta) are materials used in orthopaedic dental implants due to their excellent mechanical properties biocompatibility. However, bioactivity osteoconductivity is low. With a view improving the of these we hypothesised that surface Ta TiAl6V4 can be functionalised with biomimetic, amorphous nano-sized calcium phosphate (CaP) apatite-like deposits, instead creating uniform coatings, which lead flaking, delamination poor adherence. We metal discs smooth rough...
Abstract Introduction Impaction allograft with cement is a common technique used in revision hip surgeries for the last 20 years. However, its clinical results are inconsistent. Recent studies have shown that mesenchymal stem cells (MSCs) seeded onto can enhance bone formation. This vitro study investigates whether increase temperature related to polymerisation of will affect viability human MSCs. Methods The MSCs was measured after incubating them at temperatures 38°C, 48°C and 58°C;...
Purpose: The purpose of this study was to screen the genes and pathways that are involved in spermatogonia stem cell (SSC) differentiation regulation during transition from Aundiff A1. Methods: RNA sequencing performed differentially expressed at 1 d 2 after SSC culture. KEGG pathway enrichment GO function analysis were reveal related initiation early differentiation. Results: showed Rpl21, which regulates initiation, significantly increased day expressions Fn1, Cd9, Fgf2, Itgb1, Epha2,...
Ideal goals for a primary uncemented femoral stem prosthesis are to transmit the loads femur proximally, and minimise interface migration. It has been proposed that addition of lateral flare which lower region greater trochanter will contribute positively these goals. Analytical radiographic studies were used study load transfer between bone, A comparison was made straight stem, with flare. The finite element showed migrated down canal approximately four millimeters before stabilisation...
Symmetrical, asymmetrical, and custom asymmetrical stems without collars were manufactured inserted cement, in that order, into each of eight femora. Displacement transducers mounted at different locations to measure relative motion between the stem bone. A load was applied simulate forces acting on a hip joint single-limb stance. force 1000 newtons three times order seat prosthesis, then cyclical head prosthesis; readings taken every 500 cycles, until 2500 cycles had been reached. The...
Abstract Tissue engineering approaches to regenerate bone stock in revision total hip replacements could enhance the longevity of implant and benefit quality patient's life. This study investigated impaction allograft with mesenchymal stem cells an ovine hemiarthroplasty model. In total, 10 sheep were divided into two groups 5 each group. The were: 1) mixed allograft; 2) only as a control. Ground reaction force was assessed for limb function showed that there no significant difference...
Acellular nerve allografts (ANA) possess bioactivity and neurite promoting factors in tissue engineering. Previously we reported that low dose ultrashort wave (USW) radiation could enhance the rate quality of peripheral regeneration with ANA repairing sciatic defects. Meanwhile, implanted bone marrow stromal cells (BMSCs) exhibited a similar result. Thus, it is interesting to know whether might yield synergistic effect when USW combined BMSCs-laden ANA. Here investigated effectiveness seeded...
Abstract Differences in the cross‐sectional shapes of intramedullary stems are expected to affect strains femur, a close proximal fit being proposed as particularly advantageous. We compared uncemented femoral different designs, well cemented stem, using intact femur control. The collarless were custom‐made, standard asymmetric, symmetric (i.e., neutral), and symmetric. These types stem inserted sequence into eight cadaver femurs. A photoelastic coating technique was used give measure shear...
Background and purpose — Muscle atrophy is seen in patients with metal-on-metal (MOM) hip implants, probably because of inflammatory destruction the musculo-tendon junction. However, like pseudotumors, it unclear when occurs whether progresses time. Our objective was to determine muscle associated MOM implants Patients methods We retrospectively reviewed 74 hips 56 (32 them women) using serial MRI. Median age 59 (23–83) years. The median time post-implantation 83 (35–142) months, interval...
The present study aimed to evaluate the molecular mechanisms underlying combinatorial bone marrow stromal cell (BMSC) transplantation and chondroitinase ABC (Ch‑ABC) therapy in a model of acellular nerve allograft (ANA) repair sciatic gap rats. Sprague Dawley rats (n=24) were used as donors Wistar (n=48) randomly divided into following groups: Group I, Dulbecco's modified Eagle's medium (DMEM) control group (ANA treated with DMEM only); II, Ch‑ABC III, BMSC seeded BMSCs IV, + (Ch‑ABC ANA...