Biomedical micro/nanorobots as active delivery systems with the features of self-propulsion and controllable navigation have made tremendous progress in disease therapy diagnosis, detection, biodetoxification. However, existing are still suffering from complex drug loading, physiological stability, uncontrollable release. To solve these problems, nanocatalytic medicine two independent research fields were integrated this study to achieve self-propulsion-induced deeper tumor penetration...

Conventional chemotherapy drugs such as paclitaxel (PTX) can effectively inhibit tumor growth by killing the majority of proliferating cancer cells; however, it also results in multi-drug resistance (MDR) and facilitates conversion non-cancer stem cells (non-CSCs) to (CSCs), which are considered reason for resistance, relapse, metastasis. Thus, exploring combination therapy with multiple chemotherapeutics is a promising approach simultaneously eliminating CSCs non-CSCs. Here, we fabricated...

Chemo-photothermal therapy shows great potential for inhibiting tumor growth. However, achieving maximal chemo-photothermal synergistic efficacy is challenging because of the low efficiency controllable chemo-drug release in response to external or internal triggers. Thus, a nano-delivery system that could effectively achieve photothermal and dual stimuli-responsive (heat pH) drug inhibit both primary breast growth metastases required.

Fumarase catalyzes the interconversion of fumarate and L-malate in tricarboxylic acid cycle. The Dahl salt-sensitive (SS) rat, a model hypertension, exhibits fumarase insufficiencies. To investigate mechanism mediating effect fumarase-related metabolites on we considered pathway which can be converted to oxaloacetate, aspartate, argininosuccinate, L-arginine, substrate nitric oxide (NO) synthase. levels citrulline, NO were significantly decreased kidneys SS rats compared salt-insensitive...

In addition to its vasodilatory effect, ligustrazine (LZ) improves the sensitivity of multidrug resistant cancer cells chemotherapeutic agents. To enhance specificity LZ delivery tumor cells/tissues, folate‑chitosan nanoparticles (FA‑CS‑NPs) were synthesized by combination folate ester with amine group on chitosan serve as a vehicle for (FA‑CS‑LZ‑NPs). The structure and characteristics FA‑CS‑LZ‑NPs, including size, encapsulation efficiency, loading capacity release rates analyzed. MCF‑7...

The ferroptosis pathway is recognized as an essential strategy for tumor treatment. However, killing cells in deep regions with agents still challenging because of distinct size requirements intratumoral accumulation and penetration. Herein, intelligent nanocapsules size-switchable capability that responds to acid/hyperthermia stimulation achieve are developed. These constructed using poly(lactic-co-glycolic) acid Pluronic F127 carrier materials, Au-Fe

Purpose To present a pulse sequence and mathematical models for quantification of blood–brain barrier water exchange permeability. Methods Motion‐compensated diffusion‐weighted (MCDW) gradient‐and‐spin echo (GRASE) pseudo‐continuous arterial spin labeling (pCASL) was proposed to acquire intravascular/extravascular perfusion signals from five postlabeling delays (PLDs, 1590–2790 ms). Experiments were performed on 11 healthy subjects at 3 T. A comprehensive set permeability parameters...

Due to advances in high-frequency ultrasound technology, it is easier detect fine structures of skin lesions. The aim this study was examine the ultrasonographic features and use recurrence risk stratification assess diagnostic performance pre-operative examination basal cell carcinoma (BCC).This a retrospective study. Forty-six BCC lesions underwent using 50- 20-MHz probes. Ultrasonographic shape, margin, internal echoes, hyper-echoic spots, posterior depth lesion were evaluated correlated...

As a result of their ability to transform into bulk cancer cells and resistance radiotherapy chemotherapy, stem (CSCs) are currently considered as major obstacle for treatment. Application multiple drugs using nanocarriers is promising approach simultaneously eliminate noncancer (non-CSCs) CSCs. Herein, employ the advantages nanomedicine while avoiding new excipients, pH-responsive prodrug (PEG-CH═N-DOX) was employed surfactant fabricate cargo-free codelivery DOX conjugated with SN38...

Fulfilling potentials of ultrahigh field for pseudo-Continuous Arterial Spin Labeling (pCASL) has been hampered by B1/B0 inhomogeneities that affect pCASL labeling, background suppression (BS), and the readout sequence. This study aimed to present a whole-cerebrum distortion-free three-dimensional (3D) sequence at 7T optimizing labeling parameters, BS pulses, an accelerated Turbo-FLASH (TFL) readout. A new set parameters (G

Introduction Global phase III clinical trials have shown superior hypoglycemic efficacy to insulin and other oral agents. However, there is a scarcity of real-world data comparing different glucagon-like peptide 1 receptor agonist (GLP-1RA) directly. This study aimed assess the safety effectiveness various GLP-1RA in treating type 2 diabetes mellitus (T2DM) setting identify predictive factors for favorable treatment outcomes. Methods was retrospective, single-center, study. The changes...

Abstract Purpose To present a Swin Transformer‐based deep learning (DL) model (SwinIR) for denoising single‐delay and multi‐delay 3D arterial spin labeling (ASL) compare its performance with convolutional neural network (CNN) other methods. Methods SwinIR CNN‐based spatial models were developed ASL. The trained on 66 subjects (119 scans) tested 39 (44 from three different vendors. Spatiotemporal using another dataset (6 subjects, 10 of A range input conditions was single ASL, respectively....

We examined the expression of ezrin and moesin in laryngeal squamous cell carcinoma (LSCC) their correlation with patient clinicopathological characteristics overall survival.Immunohistochemical staining reverse transcription-polymerase chain reaction (RT-PCR) for were applied to 60 tissues, adjacent normal 33 metastatic lymph nodes.Survival functions estimated using Kaplan-Meier method compared by log-rank test.RT-PCR demonstrated that intensity ratios β-actin higher LSCC than mucous...

Purpose To optimize pseudo‐continuous arterial spin labeling (pCASL) for 7 T, and to further improve the efficiency with parallel RF transmission transmit B 1 ( ) shimming. Methods pCASL parameters were optimized based on field distributions at T simulation. increase efficiency, amplitude inflowing arteries was increased The “indv‐shim” shimming weights calculated each individual subject, “univ‐shim” universal a group of 12 subjects, compared circular polarized (CP) shim. sequences three...

Abstract Background Background: Parotid gland neoplasms occur near the facial nerve. Hence, it is crucial to determine whether malignant involve nerve and sacrifice of in surgery necessary. Furthermore, while 20% all are malignant, most common benign neoplasm, pleomorphic adenoma, has a risk for transformation, making early detection treatment essential. 7T magnetic resonance imaging offers increased signal‐to‐noise ratio (SNR) sensitivity. Aim In this work, we address parotid since remains...

To predict subject-specific local specific absorption rate (SAR) distributions of the human head for parallel transmission (pTx) systems at 7 T.Electromagnetic energy deposition in tissues is nonuniform T, and interference patterns due to individual channels pTx may result increased SAR values, which can only be estimated with very high safety margins. We proposed, designed, demonstrated a multichannel 3D convolutional neural network (CNN) architecture maps as well peak-spatial (ps-SAR)...

CTP (Computed Tomography Perfusion) is widely used in clinical practice for the evaluation of cerebrovascular disorders. However, involves high radiation dose (≥~200mGy) as X-ray source remains continuously on during passage contrast media. The purpose this study to present a low technique termed K-space Weighted Image Average (KWIA) using novel projection view-shared averaging algorithm with reduced tube current. KWIA takes advantage k-space signal property that image primarily determined...

To present a Swin Transformer-based deep learning (DL) model for denoising of single-delay and multi-delay 3D arterial spin labeling (ASL) compare its performance with convolutional neural network (CNN) methods.Swin Transformer CNN-based spatial models were developed ASL. The trained on 59 subjects (104 scans) tested 44 (57 from 3 different vendors. Spatiotemporal using another dataset (6 subjects, 10 A range input conditions was single ASL respectively. evaluated similarity metrics,...

Multi-delay arterial spin labeling (MDASL) can quantitatively measure cerebral blood flow (CBF) and transit time (ATT), which is particularly suitable for pediatric perfusion imaging. Here we present a high resolution (iso-2mm) MDASL protocol performed test-retest scans on 21 typically developing children aged 8 to 17 years. We further proposed Transformer-based deep learning (DL) model with k-space weighted image average (KWIA) denoised images as reference training the model. The...