A5100327854- Sinusitis and nasal conditions
- Asthma and respiratory diseases
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Ear Surgery and Otitis Media
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Nasal Surgery and Airway Studies
- Otitis Media and Relapsing Polychondritis
- Salivary Gland Disorders and Functions
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Pain Mechanisms and Treatments
- Breast Lesions and Carcinomas
- Allergic Rhinitis and Sensitization
- Dysphagia Assessment and Management
- Oral microbiology and periodontitis research
- Nutrition and Health in Aging
- Breast Cancer Treatment Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Psoriasis: Treatment and Pathogenesis
- HER2/EGFR in Cancer Research
- Ear and Head Tumors
- IgG4-Related and Inflammatory Diseases
- Lung Cancer Diagnosis and Treatment
Jinan University
2025
Shenzhen Children's Hospital
2025
First Affiliated Hospital of Bengbu Medical College
2023-2024
Institut Català d'Ornitologia
2024
Institut Català d'Oncologia
2022-2024
Institut d'Investigació Biomédica de Bellvitge
2022-2024
Jilin University
2005-2023
Second Affiliated Hospital of Harbin Medical University
2011-2023
Harbin Medical University
2011-2023
Government of the United States of America
2023
The underlying mechanisms of pediatric antrochoanal polyps (ACP)and chronic rhinosinusitis with nasal (CRSwNP) remain largely unexplored. This study investigates their proteomic and metabolomic profiles to uncover unique overlapping pathways, shedding light on causes. Specimens were collected from six children ACP, CRSwNP, normal inferior turbinate mucosa (CK) at Shenzhen Children's Hospital. Protein analyzed using data-independent acquisition (DIA) mass spectrometry, while metabolite...
Objective This study aimed to explore the shared mechanism and candidate drugs of multiple sclerosis (MS) Sjögren’s syndrome (SS). Methods MS- SS-related susceptibility genes differentially expressed (DEGs) were identified by bioinformatics analysis based on genome-wide association studies (GWAS) transcriptome data from GWAS catalog Gene Expression Omnibus (GEO) database. Pathway enrichment, Ontology (GO) analysis, protein–protein interaction for DEGs performed. The targeting common...
Background: Tests or test algorithms for diagnosing HPV-driven oral cavity and laryngeal head neck carcinomas (HNC) have not been yet validated, the differences among sites comprehensively evaluated. We aimed to assess utility of a diagnostic algorithm detection (OCC), oropharyngeal (OPC) (LC) using HPV-DNA testing followed by p16INK4a immunohistochemistry, taking E6*I mRNA as reference standard. Methods: Formalin-fixed paraffin-embedded OCC, OPC, LC were collected from pathology archives in...
<i>Objective:</i> To identify the regulatory mechanisms of Toll- like receptor (TLR)-associated genes in chronic rhinosinusitis (CRS) with nasal polyps (NP) using gene microarray analyses. <i>Methods:</i> We pooled: (1) NP biopsy specimens from 10 nonatopic CRS patients and (2) healthy mucosal tissue additional (controls). These pooled samples were evaluated by microarrays that included 125 for TLRs associated signaling elements. validate product expressions, 20 15...
Objectives: We performed this study to investigate the expression profile of immune-associated genes and probe role related in immune pathogenesis nasal polyps. Methods: Microarray analysis was used find 491 In validation studies, immunohistochemical staining Western blot were detect interleukin (IL)–17 IL-17 receptor (IL-17R) polyps controls. Results: Eighty-seven differentially expressed gene polyps, 15 showed differential both chips. polyp tissues, mainly cytoplasm plasma cells a lesser...
We examined the expression of ezrin and moesin in laryngeal squamous cell carcinoma (LSCC) their correlation with patient clinicopathological characteristics overall survival.Immunohistochemical staining reverse transcription-polymerase chain reaction (RT-PCR) for were applied to 60 tissues, adjacent normal 33 metastatic lymph nodes.Survival functions estimated using Kaplan-Meier method compared by log-rank test.RT-PCR demonstrated that intensity ratios β-actin higher LSCC than mucous...
Neuropathic pain is one of the most intractable diseases. The lack effective therapy measures remains a critical problem due to poor understanding cause neuropathic pain. aim this study was investigate effect dexmedetomidine (Dex) in trigeminal and underlying molecular mechanism order identify possible therapeutic targets. We used chronic constriction injury (CCI) model mice whether Dex prevents inflammation response. α 2-adrenoceptors (α2AR) inhibitor BRL44408 adenovirus for knocking down...
<b><i>Background:</i></b> Suppressor of cytokine signaling 1 (SOCS1) and SOCS3 play important roles in T helper cell differentiation, which is involved with the pathologic mechanisms allergic rhinitis (AR). The aim this study was to evaluate expression SOCS1 AR find their regulatory microRNAs (miRNAs) provide a basis for treatment AR. <b><i>Methods:</i></b> were analyzed by real-time PCR, immunohistochemistry, Western blot. correlative miRNAs...
MicroRNAs (miRNAs) play crucial roles in the pathogenesis of neuropathic pain. The present study investigated effects miR-448 on progression pain a rat model chronic constriction injury (CCI) sciatic nerve. Reverse-transcription quantitative polymerase chain reaction was conducted to detect gene expression. paw withdrawal threshold (PWT) and latency (PWL) were used assess threshold. protein expression levels interleukin (IL)-6, IL-1β tumor necrosis factor-α (TNF-α) detected by ELISA. target...
Abstract: Primary pulmonary inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) is extremely rare. Here, we report a case of 64-year-old female with primary IPT-like FDCS. The patient was found to have solid nodule in the right lower lobe (RLL) lung incidentally without any symptoms or signs discomfort. chest computed tomography (CT) showed that there an irregular basal segment RLL, approximately 2.0 cm × 1.1 1.0 size, 15 HU CT value. While result fiberoptic...
Abstract Background The labial salivary glands (LSGs) are important for the diagnosis, evaluation of therapeutic efficacy, and genetic analyses primary Sjögren’s syndrome (pSS). In autoimmune diseases, recognition self nucleic acids viral RNA DNA through endogenous Toll-like receptor(TLR) triggers production type I IFN pro-inflammatory cytokines, leading to occurrence progression disease. Here, we detected expression TLR7 in LSGs analyse its correlation with clinical features serum cytokines...
Objective: To compare the clinical effects of concurrent radiochemotherapy with those radiotherapy in treating locally advanced nasopharyngeal carcinoma (Stage III~IVa). Methods: A total 95 patients suffering from III~IVa) were divided into two groups: (Group CCRT, n=49) and RT, n=46). The groups both delivered conventional fractionated radiotherapy, while Group CCRT also received three cycles PF (DDP+5-Fu) or PLF (DDP+5-Fu+CF) chemotherapy. Results: complete remission rate higher than RT...
Backgrounds: With the excellent local control in T1 to T3 nasopharyngeal carcinoma (NPC) treated with intensity modulated radiotherapy (IMRT), importance of toxicities is increasingly being recognised.This retrospective propensity score analysis sought assess whether moderate dose reduction compromised long-term outcome compared standard T1-3 NPCs.Materials and Methods: A total 266 patients (67 female, 199 male) a median age 50 years between June 2011 2015 were analysed.All IMRT, or without...
IgA nephropathy (IgAN) is characterized by high serum levels and deposition in the renal mesangium. Recent research has indicated that pathogenic may originate from affected tonsils, where present enhancement of production class switching immuno-activation. Tripterygium Wilfordii (TW) was found to be especially effective IgAN its' immunosuppression effect. Given this background, we investigated mechanisms underlying role TW generation tonsillar GCs patients. Immunohistochemistry RT-PCR...