A5101561139- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- MicroRNA in disease regulation
- Air Quality and Health Impacts
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Myasthenia Gravis and Thymoma
- Cancer-related gene regulation
- Estrogen and related hormone effects
- Cancer Risks and Factors
- Cell death mechanisms and regulation
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Genetic factors in colorectal cancer
- Inflammatory mediators and NSAID effects
- PARP inhibition in cancer therapy
- Sirtuins and Resveratrol in Medicine
- NF-κB Signaling Pathways
- Metabolomics and Mass Spectrometry Studies
- Kidney Stones and Urolithiasis Treatments
- Hippo pathway signaling and YAP/TAZ
- TGF-β signaling in diseases
- Cancer Mechanisms and Therapy
Shanghai Ninth People's Hospital
2020-2024
Shanghai Jiao Tong University
2024
ZheJiang Academy of Agricultural Sciences
2017-2023
Animal Science Research Institute
2017-2023
Daping Hospital
2006-2022
Army Medical University
2009-2022
Chinese People's Liberation Army
2022
Mayo Clinic
2013-2017
Mayo Clinic in Florida
2014-2016
Southwest University
2016
Background Under stress, AMP-activated protein kinase (AMPK) plays a central role in energy balance, and the heat shock response is protective mechanism for cell survival. The relationship between AMPK activity (HSP) expression under stress unclear. Methodology/Principal Findings We found that induced dephosphorylation of AMPKα subunit (AMPKα) various types from human rodent. In HepG2 cells, turn caused acetyl-CoA carboxylase upregulation phosphoenolpyruvate carboxykinase, two downstream...
Novel and targetable mutations are needed for improved understanding treatment of lung cancer in never-smokers. Twenty-seven adenocarcinomas from never-smokers were sequenced by both exome mRNA-seq with respective normal tissues. Somatic detected compared pathway deregulation, tumor phenotypes clinical outcomes. Although somatic DNA or mRNA ranged hundreds to thousands each tumor, the overlap between two only a few couple hundreds. The number either was not significantly associated...
An important precursor to lung cancer development is chronic obstructive pulmonary disease (COPD), independent of exposure tobacco smoke. Both diseases are associated with increased host susceptibility, inflammation, and genomic instability. However, validation the candidate genes functional confirmation test shared genetic contribution cellular mechanisms in patients COPD remains underexplored. Here, we show that loss PARK2 (encoding Parkin) increases expression proinflammation factors as...
Objective To explore the association between representative insulin resistance (IR) indices and risk of kidney stone disease in an American adult population. The IR referred to metabolic score for (METS-IR), triglyceride high-density lipoprotein cholesterol (TG/HDL-C) ratio, glucose-body mass index (TyG-BMI), visceral adiposity (VAI), homeostatic model assessment (HOMA-IR). Methods We investigated participants who joined 2015–2018 National Health Nutrition Examination Survey (NHANES)...
Objective Our previous study suggested the potential clinical implications of BCAR1 in non-small-cell lung cancer (NSCLC) (Mol Diagn Ther. 2011. 15(1): 31–40). Herein, we aim to evaluate predictive power as a marker for poor prognosis NSCLC cases, verify carcinogenic roles A549 adenocarcinoma cell line, and testify BCAR1/phospho-p38 axis. Methods Between January 2006 June 2010, there were total 182 patients with (151 cases available follow up data, 31 lost follow-up due invalid contact...
The aim of this study was to evaluate the safety and effectiveness robot-assisted thymectomy (RAT) in large anterior mediastinal tumors (AMTs) (size ≥6 cm) compared with video-assisted (VAT) open surgery.A total 132 patients AMTs who underwent surgical resection from January 2016 June 2022 were included study. A 61 RAT, 36 VAT 35 surgery. Perioperative outcomes compared.There no significant differences tumor size (p = 0.141), or pathological types 0.903). Compared group, RAT groups...
Abstract Low sensitivity to chemotherapy has been a major challenge in the treatment of non-small-cell lung cancer (NSCLC). It is great clinical significance discover its mechanisms improve cell chemotherapeutic drugs. The forkhead box subfamily O (FOXO) transcriptional factors are downstream phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathway and reported play pro-apoptotic roles variety cells including NSCLC cells. But their mediating response remain be discovered. We...
Interleukin (IL)‑1β is a member of the IL‑1 family proteins. receptor antagonist (IL‑1RA) an agent that binds to receptor, preventing from transmitting signals cells. The present study aimed identify role IL‑1β/1RA axis in epithelial‑mesenchymal transition (EMT), cell invasion, migration, proliferation and clone formation colorectal cancer (CRC) determine its underlying mechanisms action. Significantly increased expression both IL‑1β IL‑1RA was identified CRC patient data uploaded Cancer...
Even with optimal surgery, many early-stage non-small cell lung cancer (NSCLC) patients die of recurrence. Unfortunately, there are no precise predictors for postoperative recurrence in NSCLC, and the mechanism is still unclear. In this study, we found that simultaneous overexpression all miRNAs miR-23a/27a/24-2 cluster was closely associated recurrence, β-catenin upregulation promoter methylation p16 CDH13 NSCLC patients. addition, vitro vivo experiments show or inhibition significantly...
Background This study was designed to investigate the effects of a novel carcinogenetic molecule, p130cas (breast cancer antiestrogen resistance protein 1 or BCAR1) on proliferation and cell growth in lung adenocarcinoma. The also aimed identify possible underlying signal networks BCAR1. Methods First, we evaluated proliferation, colony formation, apoptosis, cycle after BCAR1 knocked out (KO) using CRISPR‐Cas9 technology H1975 H1299 human adenocarcinoma cells. Subsequently, upregulated 293T...
In lung cancer A549 cells, the present study evaluated associations between p130cas expression and activation of p38 or Smad2, which are components two main signaling pathways transforming growth factor-β1 (TGF-β1), i.e., epithelial-mesenchymal transition (EMT) apoptosis, respectively. TGF-β1-induced EMT was investigated by inspecting cell shape migration, testing E-Cadherin, N-Cadherin Vimentin biomarkers in p130cas-RNA interference (RNAi)-A549 cells. The changes cleaved Caspase-3 levels,...
This study investigated the expression profiles of Wnt genes in adult porcine longissimus dorsi (LD) from different genotypes and their associations with meat quality. The results showed that Wnt5a gene level was highest Jinhua (JHP) pigs, followed by Zhongbai (ZBP), Duroc×Zhongbai (DZB), Duroc×Yorkshire×Landrace (DYL) significant differences between ZBP, DZB, DYL (P<0.05). genotypic order reversed for Wnt7a, Wnt10b, Wnt11 expression, JHP having lowest expressive levels, respectively....
Objective: Our previous study suggested the potential clinical implications of BCAR1 in non-small-cell lung cancer (NSCLC) (Mol Diagn Ther.2011.15(1): 31-40).Herein, we aim to evaluate predictive power as a marker for poor prognosis NSCLC cases, verify carcinogenic roles A549 adenocarcinoma cell line, and testify BCAR1/phospho-p38 axis.Methods: Between January 2006 June 2010, there were total 182 patients with (151 cases available follow up data, 31 lost follow-up due invalid contact...
Long noncoding RNAs (lncRNAs) play crucial roles in various biological processes, and they are considered to be closely associated with the pathogenesis of intestinal diseases. However, role expression lncRNAs damage during weaning stress remain unknown. Herein, we investigated profiles jejunal tissue from piglets at 4 7 d after (groups W4 W7, respectively) suckling on same days S4 S7, respectively). Genome-wide analysis was also performed using RNA sequencing technology. A total 1809...
<p>NCI-MD Case-Control Study Genomic DNA was isolated from buffy coat samples containing white blood cells using Flexigene Kit (Qiagen) according to the manufacturer's instructions.</p>