A5101525457- Hepatitis C virus research
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Biochemical and Molecular Research
- Peroxisome Proliferator-Activated Receptors
- Adenosine and Purinergic Signaling
- Retinal Development and Disorders
- Gastric Cancer Management and Outcomes
- Retinoids in leukemia and cellular processes
- RNA regulation and disease
- Gastroesophageal reflux and treatments
- Retinal Diseases and Treatments
- RNA and protein synthesis mechanisms
- Lung Cancer Treatments and Mutations
- Eicosanoids and Hypertension Pharmacology
- Cytokine Signaling Pathways and Interactions
- Inflammatory mediators and NSAID effects
- Sirtuins and Resveratrol in Medicine
- Microbial metabolism and enzyme function
- Folate and B Vitamins Research
- Pharmacological Receptor Mechanisms and Effects
University of Electronic Science and Technology of China
2024
Eon Corporation (United States)
2020-2023
Research Center Borstel - Leibniz Lung Center
2022
Xi'an University of Finance and Economics
2022
Binzhou People's Hospital
2011-2021
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2014-2021
The Seventh Affiliated Hospital of Sun Yat-sen University
2021
Sun Yat-sen University
2021
Shanghai Sixth People's Hospital
2021
Chinese PLA General Hospital
2020
Efforts to target glucose metabolism in cancer have been limited by the poor potency and specificity of existing anti-glycolytic agents a understanding dependence subtypes vivo. Here, we present an extensively characterized series potent, orally bioavailable inhibitors class I transporters (GLUTs). The representative compound KL-11743 specifically blocks metabolism, triggering acute collapse NADH pools striking accumulation aspartate, indicating dramatic shift toward oxidative...
Abstract T effector cells promote inflammation in asthmatic patients, and both Th2 Th17 CD4 have been implicated severe forms of the disease. The metabolic phenotypes dependencies these cells, however, remain poorly understood regulation airway inflammation. In this study, we show bronchoalveolar lavage fluid patients had markers elevated glucose glutamine metabolism. Further, peripheral blood asthmatics broadly expression proteins when analyzed by mass cytometry compared with healthy...
Obesity is increasing worldwide and leads to a multitude of metabolic diseases, including cardiovascular disease, type 2 diabetes, nonalcoholic fatty liver steatohepatitis (NASH). Cysteine-rich angiogenic inducer 61 (CYR61) associated with the progression NASH, but it has been described have anti- proinflammatory properties. We sought examine role CYR61 in NASH progression. liver-specific knockout mice on diet showed improved glucose tolerance, decreased inflammation, reduced fibrosis....
Abstract N,N ‐Dimethylaminophenyl moiety is a common fragment in medicinal chemistry as several pharmaceuticals bearing this privileged motif are on the market and under clinical evaluation. Oxidative N ‐demethylation generally regarded major metabolic pathway. However, pharmacokinetics, metabolites studies well further structural modification precluded by impracticality of chemical synthesis. Here we report that acetic acid can significantly accelerate visible‐light photoredox catalyzed...
A major obstacle in the treatment of chronic hepatitis C virus (HCV) infection has been lack effective, well-tolerated therapeutics. Notably, recent development HCV cell culture system now allows not only for study entire viral life cycle, but also screening inhibitors against all aspects infection. However, order to screen libraries potential antiviral compounds, it is necessary develop a highly reproducible, accurate assay adaptable high-throughput (HTS) automation. Using an internally...
We aimed, in the present study, to measure risk related high-grade cervical intraepithelial neoplasia grade 3 (CIN3) or worse (CIN3+) worse/high-grade squamous lesions with respect changes human papillomavirus (HPV) and smoking status.A structured interview underwent for 7129 women. Then, we obtained their cells subjected HPV testing. High-risk infected "no prevalent" disease women were followed up 12 years (at baseline; n = 1531). Hazard ratios (HRs) diagnosis of CIN3 (or worse) calculated...
Aerobic glycolysis, originally identified by Warburg as a hallmark of cancer, has recently been implicated in immune cell activation and growth. Glucose, the starting material for is transported through cellular membrane family glucose transporters (GLUTs). Therefore, targeting to regulate aerobic glycolysis an attractive approach identify potential therapeutic agents cancers autoimmune diseases. Herein, we describe discovery optimization class potent, orally bioavailable inhibitors...
Abstract Abnormal vascular smooth muscle cell (VSMC) proliferation plays an important role in the pathogenesis of both atherosclerosis and restenosis. Recent studies suggest that high-dose salicylates, addition to inhibiting cyclooxygenase activity, exert antiproliferative effect on VSMC growth in-vitro in-vivo. However, whether all non-steroidal anti-inflammatory drugs (NSAIDs) similar effects VSMCs, do so via a common mechanism action, remains be shown. In this study, we demonstrate NSAIDs...
Abstract Peroxisome proliferator-activated receptors (PPARs) are lipid-sensing nuclear that have been implicated in multiple physiologic processes including cancer. Here, we determine PPARδ induces cell proliferation through a novel cyclin E1–dependent mechanism and is up-regulated many human thyroid tumors. The expression of was induced coordinately with primary cells by the activation serum, thyroid-stimulating hormone/cyclic AMP, or epidermal growth factor/mitogen-activated protein kinase...
<b><i>Objective:</i></b> This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C methionine synthase (MTRR) A66G polymorphisms pregnant women in Jiaodong region China, investigate whether folic acid supplementation affect pregnancy complications. <b><i>Setting:</i></b> A total 7,812 from Shandong province China. <b><i>Methods:</i></b> By...
This study was to investigate the effect of resveratrol (RSV) administration on diabetes-induced neural apoptosis and RNA-dependent-protein-kinase (PKR)-associated protein X (RAX), PKR phosphorylated (P-PKR) expression distribution in retina diabetic rats.Retina obtained from normal Sprague-Dawley rats with or without RSV (5 10 mg/kg/d) treatment at 30-, 32-, 34- 36-weeks. Apoptosis retinal cells RAX/P-PKR assessed by TUNEL immunofluorescence methods. Expression RAX, P-PKR evaluated qRT-PCR...
One common feature of the more than 1,000 complement-type repeats (or low density lipoprotein (LDL)-A modules) found in LDL receptor and other members superfamily is a cluster five highly conserved acidic residues C-terminal region, DXXXDXXDXXDE. However, role third aspartate these LDL-A modules protein folding ligand recognition has not been elucidated. In this report, using model module several experimental approaches, we demonstrate that residue, like four residues, involved...
Hepatitis C virus (HCV) affects an estimated 3% of the population and is a leading cause chronic liver disease worldwide. Since HCV therapeutic preventative options are limited, development new antivirals has become global health care concern. This spurred cell-based infectious high-throughput screening assays to test ability compounds inhibit infection. unit describes methods that may be used assess in vitro efficacy using fluorescence resonance energy transfer (FRET) infection assay, which...
Abstract Background Although primary and established human hepatoma cell lines have been evaluated for hepatitis C virus (HCV) infection in vitro , thus far only Huh7 cells found to be highly permissive infectious HCV. Since our understanding of the HCV lifecycle would benefit from identification additional lines, we assembled a panel hepatic non-hepatic assessed their ability support infection. Here show PLC/PRF/5 Hep3B with culture-derived (HCVcc), albeit lower levels than that achieved...
To study the expression of PTEN, p53 and epidermal growth factor receptor (EGFR) in molecular subtypes breast carcinoma to evaluate correlations with triple-negative cancer. Immunohistochemical MaxVision(TM) method was used detect p53, EGFR, estrogen (ER), progesterone (PR) human 2 (HER2) 291 cases infiltrating ductal breast. The positive EGFR protein 57.0%, 57.0% 38.5%, respectively, which were significantly different from those benign diseases (P<0.05). PTEN or cancer correlated tumor...
Abstract Neuropathic pain is the most common chronic that caused by nerve injury or disease influences nervous system. Increasing evidence suggested microRNAs (miRNAs) play a crucial role in neuropathic and neuroinflammation development. However, functional of miR‐217 development remains unknown. In this study, we used rats to establish model showed expression level was upregulated spinal dorsal horn bilateral sciatic constriction (bCCI). not changed anterior cingulated cortex (ACC),...
With 2 to 3% of the worldwide population chronically infected, hepatitis C virus (HCV) infection continues be a major health care burden. Unfortunately, current interferon-based treatment options are not effective in all patients and associated with significant side effects. Consequently, there is an ongoing need identify develop new anti-HCV therapies. Toward this goal, we previously developed cell-based HCV assay for antiviral compound screening based on low-multiplicity-of-infection...
ABSTRACT Tva is the receptor for subgroup A Rous sarcoma virus, and it contains a single LDL-A module which site of virus interaction. In this study, we expressed entire extracellular region (referred to as Ecto-Tva) GST fusion protein characterized its refolding properties. We demonstrated that correct folding Ecto-Tva protein, like module, calcium dependent. used IAsys system measure kinetics binding between surface (SU) subunit viral glycoprotein in real time. found displayed similar...