A5071451953- Catalytic C–H Functionalization Methods
- X-ray Diffraction in Crystallography
- Oxidative Organic Chemistry Reactions
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Synthesis of Indole Derivatives
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Radical Photochemical Reactions
- Zeolite Catalysis and Synthesis
- Antimicrobial Peptides and Activities
- Biochemical and Molecular Research
- Catalysis and Oxidation Reactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthesis and characterization of novel inorganic/organometallic compounds
- Ferrocene Chemistry and Applications
- Asymmetric Hydrogenation and Catalysis
- Monoclonal and Polyclonal Antibodies Research
- Abdominal Surgery and Complications
- Sulfur-Based Synthesis Techniques
- Nerve injury and regeneration
- Acupuncture Treatment Research Studies
Fudan University
1993-2024
Fuzhou University
2016-2019
Zhongshan Hospital
2018
Southwest University
2016
Peking University
2012-2014
State Key Laboratory of Organometallic Chemistry
2012
Chinese Academy of Sciences
2012
Shanghai University
2010
Shanghai Medical College of Fudan University
2010
Nanchang University
1994
Oxygen? That's radical! A method for the direct synthesis of substituted alcohols, ketones, and diketones through a catalyst-controlled highly chemoselective coupling oxygenation olefins has been developed. The is simple practical, can be switched by selection different catalysts, employs molecular oxygen as both an oxidant reagent.
A novel Mn-promoted aerobic oxidative C–C bond cleavage of aldehydes with dioxygen activation has been developed. The usage molecular oxygen (1 atm) as oxidant, reactant, and an initiator to trigger this transformation makes very green practical. plausible radical process is proposed on the basis mechanistic studies. Furthermore, method provides a practical, neutral, mild synthetic approach formamides, which are important units in biologically active molecules.
Abstract The observation of an unexpected oxidative rearrangement coupling reaction led to the development a novel method for efficient functionalization tetrahydro‐β‐carbolines (THβCs). treatment THβCs with photogenerated singlet oxygen ( 1 O 2 ) afforded unstable dioxetanes, which underwent further transformation form new bonds in presence trifluoroacetic acid. This operationally simple protocol exhibits broad functional‐group tolerance and is suitable late‐stage complex druglike molecules.
Der direkte Zugang zu substituierten Alkoholen, Ketonen und Diketonen im Sinne der Titelreaktion ist einfach praktisch, kann über die Auswahl unterschiedlicher Katalysatoren gelenkt werden nutzt molekularen Sauerstoff als Oxidationsmittel Reagens.
Abstract N,N ‐Dimethylaminophenyl moiety is a common fragment in medicinal chemistry as several pharmaceuticals bearing this privileged motif are on the market and under clinical evaluation. Oxidative N ‐demethylation generally regarded major metabolic pathway. However, pharmacokinetics, metabolites studies well further structural modification precluded by impracticality of chemical synthesis. Here we report that acetic acid can significantly accelerate visible‐light photoredox catalyzed...
Abstract Naturally occurring conjugated allenynes are of general interest owing to their potent and various biological activities. The 1,5‐H transfer alka‐1,4‐diyn‐3‐yl amines would be one the most straightforward yet challenging approaches such compounds since, in principle, two regioisomers may formed involving C−C triple bonds. Herein, a catalytic recipe copper halides with mixed oxidation states, i.e., CuCl/CuBr 2 , has been identified address issues side reaction conjugate addition...
Chirality is one of the most important types steric information in nature. In addition to central chirality, axial chirality has been catching more and attention from scientists. However, although much recently paid creation transfer allenes, no study disclosed as memory such an chirality. The reason very obvious: chiral stored over three carbon atoms. Here, first example (MOC) allenes recorded, which was realized via optically active alkylidene-π-allyl iridium intermediate, leading a highly...
Global profiling of the target proteins ART for its anti-inflammatory activity <italic>via</italic> ABPP combined with quantitative chemical proteomics.
Esters are bulk and fine chemicals ubiquitous in polymers, bioactive compounds, natural products. Their traditional synthetic approach is the esterification of carboxylic acids or their activated derivatives with alcohols. Herein, a bimetallic relay catalytic protocol was developed for aerobic one alcohol presence slowly oxidizing alcohol, which has been identified as methanol. A concise synthesis phlomic acid executed to demonstrate practicality potential this reaction.
A palladium-catalyzed C–O bond formation reaction between phenols and allenylic carbonates to give 2,3-allenic aromatic ethers with decent excellent yields under mild conditions has been described.
Herein, we report a nickel‐catalyzed crossing‐coupling reaction for the synthesis of diaryl ethers. The desired products are achieved by coupling heterocyclic alcohols with aryl bromides bearing strong electron withdrawing nitro group under catalyst system NiCl 2 (PPh 3 ) and weak base KHCO . This mild exhibits broad functional tolerance. Compound 4 as an important intermediate is suitable further structural modification MALT1 inhibitor MI‐2.
Abstract The observation of an unexpected oxidative rearrangement coupling reaction led to the development a novel method for efficient functionalization tetrahydro‐β‐carbolines (THβCs). treatment THβCs with photogenerated singlet oxygen ( 1 O 2 ) afforded unstable dioxetanes, which underwent further transformation form new bonds in presence trifluoroacetic acid. This operationally simple protocol exhibits broad functional‐group tolerance and is suitable late‐stage complex druglike molecules.
Abstract Naturally occurring conjugated allenynes are of general interest owing to their potent and various biological activities. The 1,5‐H transfer alka‐1,4‐diyn‐3‐yl amines would be one the most straightforward yet challenging approaches such compounds since, in principle, two regioisomers may formed involving C−C triple bonds. Herein, a catalytic recipe copper halides with mixed oxidation states, i.e., CuCl/CuBr 2 , has been identified address issues side reaction conjugate addition...
Abstract A method for the direct synthesis of substituted alcohols, ketones, and diketones through a catalyst‐controlled highly chemoselective coupling oxygenation olefins is developed.
Abstract An alkenylation of indoles at C‐3 is developed through tandem addition and oxidative dehydration.
Abstract Mutagenic active molecules (XIII) and (XV) the antimalarial compound (XVII) are easily synthesized under neutral conditions.