A5101604860- Pulmonary Hypertension Research and Treatments
- Pancreatitis Pathology and Treatment
- Cardiovascular Function and Risk Factors
- Intracranial Aneurysms: Treatment and Complications
- Parkinson's Disease Mechanisms and Treatments
- Occupational and environmental lung diseases
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- Advanced Sensor and Control Systems
- Frailty in Older Adults
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Virus-based gene therapy research
- Liver Diseases and Immunity
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- Diabetes Treatment and Management
- Glaucoma and retinal disorders
- Autophagy in Disease and Therapy
- Pituitary Gland Disorders and Treatments
- Lipid metabolism and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Effects of Exercise
- Genetic Neurodegenerative Diseases
- Liver Disease and Transplantation
- Cardiovascular Issues in Pregnancy
Tangshan Gongren Hospital
2021-2025
Nanjing General Hospital of Nanjing Military Command
2024
Nanjing University
2024
University of Sheffield
2023
Qingdao University
2023
Renji Hospital
2018-2022
Shanghai Jiao Tong University
2013-2022
Shanghai Changzheng Hospital
2022
Second Military Medical University
2022
The First People's Hospital of Guiyang
2021
The prognostic value of negative regulators ferroptosis in patients with colorectal cancer (CRC) has not yet been fully elucidated. present study performed a systematic silico identification and selection candidate using Cancer Genome Atlas data cohort (n=367), followed by clinical validation through immunohistochemistry samples from CRC (n=166) further vitro evaluation. In analysis identified specific light-chain subunit the cystine/glutamate antiporter, AIFM2, NFE2L2, FTH1, GLS2,...
The principal extracellular lesions of age-related maculopathy (ARM), the leading cause vision loss in elderly, involve Bruch's membrane (BrM), a thin vascular intima between retinal pigment epithelium (RPE) and its blood supply. With age, 80–100 nm solid particles containing esterified cholesterol (EC) accumulate normal BrM, apolipoprotein B (apoB) immunoreactivity is detectable BrM- ARM-associated lesions. Yet little evidence indicates that increased plasma risk factor for ARM. To...
The overall prognosis of advanced/metastatic gastric cancer (GC) remains poor despite the development pharmacotherapy. Therefore, other treatment options, such as complementary and alternative medicine, should be considered to overcome this aggressive malignancy. Andrographis, which is a generally unharmful botanical compound, has gained increasing interest for its anticancer effects in multiple malignancies via regulation progression‑associated signaling pathways. In present study, series...
Background . Pulmonary hypertension due to left ventricular heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly medical problem. The aim of the study was evaluate clinical efficacy fasudil on PH-HFpEF elderly patients and figure out subtype which may be therapeutic object fasudil. Method 58 were enrolled. Patients diagnosed passive pulmonary (PPH) or reactive (RPH) by right catheterization all receiving Rho kinase inhibitor for 2 weeks. endpoint includes changes in...
Abstract Lung cancer is a fatal disease with the highest worldwide morbidity and mortality rates. Despite recent advances in targeted therapy immune checkpoint inhibitors for cancer, their efficacy remained limited. Therefore, we designed Newcastle virus (NDV)‐modified tumor whole‐cell vaccine as therapeutic identified its antigen presentation level to develop effective immunotherapy. Then, calculated immune‐stimulating effects of NDV‐modified lung cell intratumoral NDV injection combination...
The aim of this study was to investigate the role and mechanism miR-155 in regulating autophagy a caerulein-induced acute pancreatitis (AP) cellular model. GFP-LC3 immunofluorescence assay performed detect vesicle formation pancreatic acinar cell line AR42J. AR42J cells were transfected with mimic, inhibitor, corresponding controls explore effect on autophagy. protein levels LC3-I, LC3-II, Beclin-1, p62 analyzed by western blot analysis. Dual-luciferase reporter verify interaction between...
Cardiovascular failure is one of the most relevant causes death in pulmonary hypertension (PH). With progressive increases right ventricular (RV) afterload PH patients, both RV and left (LV) function impair RV-LV dyssynchrony develop parallel. We aimed to analyze balance between deformation assess outcome patients with by means speckle tracking echocardiography. In this prospective study, 54 invasively diagnosed hypertension, 26 healthy volunteers were included underwent a broad panel...
Acute pancreatitis (AP) is a common digestive disorder with high morbidity and mortality. The present study aimed to investigate the expression of early growth response protein 1 (Egr1), effect competing endogenous (ce)RNA network on trypsinogen activation. Pancreatic acinar intracellular activation (PAITA) an important event in stage AP; however, underlying mechanisms remain unclear. used taurolithocholic acid 3‑sulfate (TLC‑S)‑treated AR42J cells (pancreatic cell line) establish PAITA...
Abstract Background This multicenter, double-blinded, randomized controlled trial (RCT) aims to assess the impact of an artificial intelligence (AI)-based model on efficacy intracranial aneurysm detection in CT angiography (CTA) and its influence patients’ short-term long-term outcomes. Methods Study design : Prospective, double-blinded RCT. Settings The was designed for automatic aneurysms from original CTA images. Participants Adult inpatients outpatients who are scheduled head scanning....
To overcome the disadvantages of traditional PID controller, a compound servo control system combining conventional and fuzzy is presented to meet demand vehicular antenna in this paper. Incorporating control, paper presents design method controller that based on tuning rules formed by integrating two above ideas. Simulation results are show efficiency proposed controller. The practical effect shows adopts has better performance than system, meets requirements system.
Objectives . To observe and analyze the parameters of sacral reflex pudendal nerve somatosensory evoked potential (SSEP) in patients with multiple system atrophy (MSA) respect to factors such as age, disease course, subtype provide evidence for clinical diagnosis MSA. Materials Methods A total 51 MSA 30 healthy controls were selected from First Affiliated Hospital Wenzhou Medical University May 2013 November 2015. Electrophysiological detection SSEP performed using Keypoint EMG/EP system....
To observe the characteristics of sacral reflex and sympathetic skin in patients with Parkinson's disease (PD) multiple system atrophy P-type (MSA-P) to analyze their value as a differential diagnostic method. The data 30 healthy people, 58 PD patients, 52 MSA-P from First Affiliated Hospital Wenzhou Medical University were collected. Electrophysiological bulbocavernosus (BCR) response (SSR) evaluated using Keypoint EMG/EP system. latency period, amplitude, extraction rate BCR SSR compared...