A5015807669- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Cancer Research and Treatments
Fudan University
2023-2025
State Key Laboratory of Medical Neurobiology
2023
A long-standing paucity of effective therapies results in the poor outcomes triple-negative breast cancer brain metastases. Immunotherapy has made progress treatment tumors, but limited by non-immunogenicity tumors and strong immunosuppressive environment, patients with TNBC metastases have not yet benefited from immunotherapy. Dual immunoregulatory strategies enhanced immune activation reversal microenvironment provide new therapeutic options for patients. Here, we propose a cocktail-like...
Abstract Apart from the blood‐brain barrier (BBB), efficacy of immunotherapy for glioblastoma (GBM) is limited by presence intrinsic and adaptive immune resistance, implying that co‐delivery various immunotherapeutic agents or simultaneous regulation different cells urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in treatment GBM, owing to their multifunctional properties as carriers adjuvants ability cross BBB. However, traditional OMVs can lead toxic side...