A5073805081- Catalytic C–H Functionalization Methods
- Catalytic Alkyne Reactions
- Pharmaceutical studies and practices
- Catalytic Cross-Coupling Reactions
- Oxidative Organic Chemistry Reactions
- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Anesthesia and Sedative Agents
- Safe Handling of Antineoplastic Drugs
- Protein purification and stability
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Analytical Chemistry and Chromatography
- Intravenous Infusion Technology and Safety
- Epilepsy research and treatment
- Crystallization and Solubility Studies
- Semiconductor materials and devices
- GaN-based semiconductor devices and materials
- Pharmacological Effects and Toxicity Studies
- Cyclopropane Reaction Mechanisms
- Redox biology and oxidative stress
- Infant Health and Development
- HIV/AIDS drug development and treatment
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
St. John Fisher College
2014-2024
Xinxiang Medical University
2022
Wuhan University
2020
Weatherford College
2020
Zhongnan Hospital of Wuhan University
2020
University of Rochester
2017
Minzu University of China
2017
University of Rochester Medical Center
2014-2015
Zhejiang University
2009-2014
American Pharmacists Association
2014
Step by step: Highly selective cross dehydrogenative arylation of acetanilides was developed to construct biaryls under mild condition. With this method, different aryl CH bonds were activated in sequential reactions functionalized carbazoles (see scheme), which are present as key structural units various biological molecules and organic optical materials.
No compass required: A method is described for forming biaryl CC bonds by a PdII-catalyzed cross-coupling of aryl CH with boronic acids under mild conditions without the presence directing groups. Different substituents on both (hetero)arenes and are compatible reaction conditions, homocoupling highly inhibited. Dioxygen was applied as final oxidant. Supporting information this article available WWW http://www.wiley-vch.de/contents/jc_2002/2008/z704619_s.pdf or from author. Please note:...
A seamless join: An efficient method to construct a C(sp2)C(sp2) bond has been developed by using Suzuki–Miyaura-type coupling of N-alkyl acetanilides with boronic acids. The reaction was catalyzed PdII species and the CH activation directed acetamino group (see scheme). This offers halogen-free complicated structures.
Indole derivative 1 interferes with the interaction of HIV surface protein gp120 host cell receptor CD4. The 4-fluoro 2 exhibited markedly enhanced potency and was bioavailable in rat, dog, cynomolgus monkey when administered orally as a solution formulation. However, aqueous suspensions were poorly bioavailable, indicative dissolution-limited absorption. 7-azaindole 3, BMS-378806, improved pharmaceutical properties while retaining HIV-1 inhibitory profile 2.
Optimization of a series R132H IDH1 inhibitors from high throughput screen led to the first potent molecules that show robust tumor 2-HG inhibition in xenograft model. Compound 35 shows good potency U87 cell based assay and ∼90% corresponding mouse model following BID dosing. The magnitude duration correlates with free plasma concentration.
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTGold(I)-Catalyzed Oxidative Cleavage of a C−C Double Bond in WaterDong Xing, Bingtao Guan, Guixin Cai, Zhao Fang, Liping Yang, and Zhangjie ShiView Author Information Key Laboratory Bioorganic Chemistry Molecular Engineering Ministry Education, College Chemistry, Peking University, Beijing 100871, China, State Organometallic Chinese Academy Sciences, Shanghai 200032, Department East China Normal 200062, Cite this: Org. Lett. 2006, 8, 4,...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTHighly Selective Aerobic Oxidation of Alcohol Catalyzed by a Gold(I) Complex with an Anionic LigandBingtao Guan, Dong Xing, Guixing Cai, Xiaobin Wan, Nan Yu, Zhao Fang, Liping Yang, and Zhangjie ShiView Author Information The Key Laboratory Bioorganic Chemistry Molecular Engineering Ministry Education, College Chemistry, Peking University, Beijing 100871, China, Department East China Normal Shanghai 200062, Cite this: J. Am. Chem. Soc. 2005,...
Schritt für Schritt: Hochselektive gekreuzte dehydrierende Arylierungen von Acetaniliden wurden zum Aufbau Biarylen unter milden Bedingungen genutzt. Unterschiedliche Arten C(Aryl)-H-Bindungen können sequenzielle Reaktionen aktiviert werden, und die Methode bietet Zugang zu funktionalisierten Carbazolen (siehe Schema), als wichtige Struktureinheiten in biologischen Molekülen organischen optischen Materialien fungieren. Supporting information for this article is available on the WWW under...
Metal-catalyzed oxidation of proteins represents an important pathway post-translational modification. We utilized human growth hormone (hGH), a protein with well defined metal-binding site, to study the detailed mechanism metal-catalyzed by ascorbate/Cu(II)/O2. Particularly His18 and His21 within site were oxidized, predominantly 2-oxo-His incorporated oxygen originating from molecular oxygen, based on amino acid analysis, tryptic mapping, mass spectrometry, isotopic labeling, 1H NMR. The...
Nahtlos verbunden: Eine effiziente Methode zur Erzeugung von C(sp2)-C(sp2)-Bindungen beruht auf der Suzuki-Miyaura-Kupplung zwischen N-Alkylacetaniliden und Boronsäuren. Die Reaktion wird durch eine PdII-Spezies katalysiert, die C-H-Aktivierung Acetaminogruppe gesteuert (siehe Schema). Das Verfahren ermöglicht den halogenfreien Aufbau komplexer Strukturen. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z700590_s.pdf or from...
A unique method was discovered to construct polysubstituted pyrroles via an unprecedented multiple deprotonations/deaminations process from commercially available phenethylamines. During this transformation, twelve bonds were broken and five new constructed.
Selective allylation: Several electron-donating arenes such as 1,3,5-trimethoxybenzene, anisole, and phenol underwent palladium-catalyzed selective allylation in TFA/dimethylacetamide (DMA) under mild conditions with 2,3-allenoates (see scheme). The reaction afforded substituted 4,4-diarylbut-2(E)-enoates moderate yields high regio- stereoselectivity. Detailed facts of importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited...
Potency assays of pharmaceutical products are designed to measure the amount an active ingredient in a sample. They important quality control tools for all medications, including intravenous (IV) admixture fluid bags which commonly prepared by pharmacists healthcare facilities via extemporaneous compounding. An interdisciplinary laboratory module was created combining learning outcomes pharmacy compounding course with classic undergraduate chemistry quantitative analysis course. The students...
Abstract The impact of electronically‐active native point defects on ZnO optoelectronic technologies at the nanoscale is only now being explored. We are able to address these Schottky barrier formation and doping using a combination depth‐resolved scanned probe techniques. clearly identify optical transitions energies V Zn clusters, Ga site donors, Li sites, effects different annealing methods their spatial distributions in ion‐implanted as well grown‐in ZnO, how , O complexes contribute...
Abstract The reaction of 2,3‐allenoates and aldehydes in the presence an alkoxide affords alkyl 4,5‐diaryl‐3‐oxo‐2‐propylpent‐4( E )‐enoates cis ‐3,4‐diaryloxetanes through a formal CO CC metathesis. A mechanism for this has been proposed.