A5022247989- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Antimicrobial agents and applications
- Cancer Research and Treatments
- Synthesis and Biological Activity
- Photoacoustic and Ultrasonic Imaging
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Retinoids in leukemia and cellular processes
- Autophagy in Disease and Therapy
- Surgical Sutures and Adhesives
- Forensic Fingerprint Detection Methods
- Ferroptosis and cancer prognosis
- Advanced Battery Materials and Technologies
- Synthesis and biological activity
- Advancements in Transdermal Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Ocular Surface and Contact Lens
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and bioactivity of alkaloids
- Photodynamic Therapy Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Natural Compounds in Disease Treatment
Guilin Medical University
2023-2025
Southeast University
2017-2024
State Key Laboratory of Digital Medical Engineering
2017-2020
Bohai University
2016-2017
Abstract Photothermal therapy (PTT) usually requires hyperthermia >50 °C for effective tumor ablation, which inevitably induces heating damage to the surrounding normal tissues/organs. Moreover, low retention and high liver accumulation are two main obstacles that significantly limit efficacy safety of many nanomedicines. To solve these problems, a smart albumin‐based microenvironment‐responsive nanoagent is designed via self‐assembly human serum albumin (HSA), dc‐IR825 (a cyanine dye...
Tumor microenvironment (TME)-responsive nanosystems represent a category of intelligent nanomaterials for precise anticancer drug delivery. Herein, we report smart size-/morphology-switchable nanodrug that can respond to the acidic TME and near-infrared (NIR) laser irradiation effective tumor ablation metastasis inhibition. The nanoagent is physically assembled by cytolytic peptide, melittin (MEL), an NIR-absorbing molecule, cypate, tumor-targeting polymer, hyaluronic acid (HA). At pH 7.4,...
Imaging the dynamics and behaviors of plasma membranes is at leading edge life science research. We report here development a universal red-fluorescent probe Chol-PEG-Cy5 for wash-free membrane labelling both in vitro vivo. In aqueous solutions, fluorescence significantly quenched due to intermolecular resonance energy transfer (RET) between neighbouring Cy5 moieties; however, upon anchoring, probes undergo lateral diffusion lipid bilayers, resulting weakened RET turn-on emission....
Biocompatible, double channel activable and photodegradable IR825-conjugated polymeric nanomicelles are developed for fluorescence imaging-guided photothermal cancer therapy.
Theranostic nanoparticles (NPs) capable of mitochondrial targeting/imaging, cancer/normal cell differentiation, early stage cancer diagnosis, and mitochondria-based photothermal therapy (PTT) were developed. The NPs fabricated by physical encapsulation near-infrared (NIR) heptamethine cyanine dye me-IR825 into the inner core micelle-forming copolymer Pluronic F127 (PF127). PF127/me-IR825 exhibited two fluorescence emissions at ∼610 nm (excited 550 nm) 845 780 nm). former was used for in...
Great efforts have been devoted to the development of novel and multifunctional wound dressing materials meet different needs healing. Herein, we covalently grafted quaternary ammonium groups (QAGs) containing 12-carbon straight-chain alkanes dextran polymer skeleton. We then oxidized resulting product into quaternized (OQD). The obtained OQD is rich in antibacterial QAGs aldehyde groups. It can react with glycol chitosan (GC) via Schiff-base reaction form a GC@OQD hydrogel good self-healing...
Abstract Alloy‐type anodes are of interest for their resource‐rich and high theoretical capacity performance in sodium‐ion batteries (SIBs). However, severe volume expansion may lead to rapid decay electrode pulverization. In this work, metallic Bi with better structure stability is rationally selected as a skeleton form 2D BiSb alloy alleviate the expansion. Interestingly, by combining in‐situ XRD ex‐situ TEM characterizations, reversible multi‐step alloying sodium storage mechanism ↔...
Abstract The anabolism of tumor cells can not only support their proliferation, but also endow them with a steady influx exogenous nutrients. Therefore, consuming metabolic substrates or limiting access to energy supply be an effective strategy impede growth. Herein, novel treatment paradigm starving‐like therapy—triple energy‐depleting therapy—is illustrated by glucose oxidase (GOx)/dc‐IR825/sorafenib liposomes (termed GISLs), and such triple therapy exhibits more tumor‐killing effect than...
The urgent need for new antimicrobial drugs arises from the limited efficacy of traditional antibiotics against emerging drug-resistant strains. Celastrol (CSL) demonstrates an exceptional antibacterial property that remains unaffected by bacterial resistance, but its poor water solubility limits wide applications. This study uses hydrophobic inner cavity mono-(6-diethylenetriamine-6-deoxy)-β-cyclodextrin (mβ-CD) (a derivative cyclodextrin) to encapsulate CSL, constructing inclusion complex...
An efficient method for the synthesis of novel isocoumarino- [3',4':4,5]pyrrolo[3,2-c]coumarins was described.The construction this new fused heterocycles system achieved undergo a domino reaction 4-aminocoumarins with ninhydrin in good yields.Coumarins and isocoumarins are an important class naturally occurring lactones, 1 which have attracted attention chemists because their various biological activities such as antioxidative, 2 anticancer 3 antiviral 4 antifungal activities. 5The...
An efficient method for the preparation of novel benz[f]indolo[3,2-c]isochromeno-5,7,13-triones 3 was described.The construction this new pentacyclic system achieved undergo a domino reaction 2-amino-1,4-naphthoquinones 1 with ninhydrin 2 in one-pot good yields.Functional heterocycles chemical and biomedical importance, particularly those containing isocoumarin ring, have played pivotal role organic medicinal research several decades. They exhibit significant biological activities such as...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Cyanine-Containing Polymeric Nanoparticles with Imaging/Therapy-Switchable Capability for Mitochondria-Targeted Cancer TheranosticsGuang-Yu PanGuang-Yu PanMore by Guang-Yu Pan, Hao-Ran JiaHao-Ran JiaMore Jia, Ya-Xuan ZhuYa-Xuan ZhuMore Zhu, Wei SunWei SunMore Sun, Xiao-Tong ChengXiao-Tong ChengMore Cheng, and Fu-Gen Wu*Fu-Gen WuMore Wuhttp://orcid.org/0000-0003-1773-2868Cite this:...
Abstract Title compounds (V) are efficiently synthesized using a Pictet—Spengler reaction of key intermediate (III), which is obtained by condensation compound (I) with 3‐cyanopyridine‐2‐thione (II) via Thorpe—Ziegler isomerization, and aromatic aldehydes (IV) under sulfamic acid catalysis in good yields.