A5030675189- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Retinopathy of Prematurity Studies
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Retinal Development and Disorders
- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Entomopathogenic Microorganisms in Pest Control
- Ocular Oncology and Treatments
- Saffron Plant Research Studies
- Advanced biosensing and bioanalysis techniques
- Vitamin D Research Studies
Chongqing Emergency Medical Center
2019-2025
Chongqing University
2019-2025
Tongji University
2009-2024
Tibet University
2024
University of British Columbia
2014-2024
Terry Fox Research Institute
2021-2024
BC Cancer Agency
2014-2024
Guangzhou University of Chinese Medicine
2020-2024
Keio University
2016-2023
University of Electronic Science and Technology of China
2021-2023
Prevalence of myopia is increasing worldwide. Outdoor activity one the most important environmental factors for control. Here we show that violet light (VL, 360-400nm wavelength) suppresses progression. First, confirmed VL suppressed axial length (AL) elongation in chick model. Expression microarray analyses revealed suppressive gene EGR1 was upregulated by exposure. exposure induced significantly higher upregulation chorioretinal tissues than blue under same conditions. Next, conducted...
The plasmonic resonance effect on metasurfaces generates an abrupt phase change. We employ this modulation mechanism to design the longitudinal field distribution of ultrathin terahertz (THz) lens for achieving axial long-focal-depth (LFD) property. Phase distributions designed are obtained by Yang-Gu iterative amplitude-phase retrieval algorithm. By depositing a 100 nm gold film 500 μm silicon substrate and etching arrayed V-shaped air holes through film, THz is fabricated micro...
The long-term clinical outcome of poor prognosis in patients with diabetic hyperglycaemic crisis episodes (HCE) remains unknown, which may be related to acute organ injury (AOI) and its continuous damage after hospital discharge. This study aimed observe the differences relevant risk factors HCE or without AOI.A total 339 inpatients were divided into an AOI group (n=69) a non-AOI (n=270), their explored. outcomes prediction models for evaluating adverse events discharge established.The...
As a new anti-diabetic medicine, Liraglutide (LIRA), one of GLP-1 analogues, has been found to have an anti-atherosclerotic effect. Since vascular smooth muscle cells (VSMCs) play pivotal roles in the occurrence diabetic atherosclerosis, it is important investigate role LIRA reducing harmful effects high-glucose (HG) treatment cultured VSMCs, and identifying associated molecular mechanisms.Primary rat VSMCs were exposed low or high glucose-containing medium with without LIRA. They challenged...
Background: Little is known about the adverse effects of frailty transitions. In this study, we aimed to characterize transitions between states and examine their associations with type death among older adults in China, a developing country rapidly growing aging population. Methods: We used data 11,165 (aged 65–99 years) from 2002 2005 waves Chinese Longitudinal Healthy Longevity Survey (CLHLS). Overall, 44 health deficits were construct index (FI; range: 0–1), which was then categorized...
Despite the global pandemic of myopia, precise molecular mechanism onset myopia remains largely unknown. This is partially because lack efficient murine myopic models that allow genetic manipulation at low cost. Here we report a highly practical and reproducible lens-induced model by specially designed frames lenses for mice. A lens power dependent induction in mice was shown until minus 30 diopter lenses. The phenotype significantly stronger than form-deprivation myopia. We presented...
Axial length is the primary determinant of eye size, and it elongated in myopia. However, underlying mechanism onset progression axial elongation remain unclear. Here, we show that endoplasmic reticulum (ER) stress sclera an essential regulator myopia development through activation both PERK ATF6 axis followed by scleral collagen remodeling. Mice with lens-induced (LIM) showed ER sclera. Pharmacological interventions for could induce or inhibit progression. LIM activated all IRE1, axis,...
We first compared long-term clinical outcomes in treating critical limb ischemia (CLI) and foot ulcer patients with diabetes between autologous bone marrow mesenchymal stem cell (BMMSC) bone-marrow-derived mononuclear (BMMNC) transplants. Forty-one were enrolled followed up for 3 years. They received an 18-day standard treatment before transplantation. Patients bilateral CLI injected intramuscularly or basally BMMSC, BMMNC, normal saline (NS). Cox model analysis showed significant...
Diabetic retinopathy (DR) is one of the leading causes blindness globally. Retinal neuronal abnormalities occur in early stage DR. Therefore, maintaining retinal activity DR may prevent vision loss. Previously, pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, was suggested as promising drug hypertriglyceridemia. However, role pemafibrate remains obscure we aimed to unravel systemic and changes by diabetes. Adult mice were intraperitoneally injected...
Abstract Cimifugin is a bioactive component of Saposhnikovia divaricata , Chinese herb for treating allergy. Our previous studies demonstrated that cimifugin inhibited allergic inflammation efficiently. This study aims to determine the mechanism on epithelial cells in inflammation. Mice were sensitized and challenged with FITC establish type 2 atopic dermatitis ( AD ) model. The initial stage model, which mice just was established vivo immortalized human epidermal (HaCaT) utilized vitro ....
Abstract Fine particulate matter is a well‐known air pollutant threatening public health. Studies have confirmed long‐term exposure to the particles could decrease pulmonary function, induce asthma exacerbation, and chronic obstructive disease, as well increase incidence mortality of lung cancer. A clinical study has explored that prevalence risks vitamin D (VD) deficiency in various disease toxins induced tissue damage. Our current aimed explore mechanism further therapeutic potential VD...
Autologous platelet-rich plasma (au-PRP) has been widely used for the management of refractory chronic wounds. However, patients with diabetic lower extremity ulcers (DLEUs) usually have complicated clinical conditions, and utility au-PRP is limited. In this study, feasibility, effectiveness, safety allogeneic (al-PRP) were investigated compared in treatment DLEUs. A total 75 in-patients type 2 diabetes assigned to al-PRP group ( n = 20), 25), conventional wound therapeutic (CWT) 30) matched...
Photovoltaic (PV) power generation is highly valued for its straightforward implementation and use of sustainable solar resources. However, PV systems in highland regions face greater variability unpredictability due to complex, fluctuating weather patterns, making accurate forecasting output difficult. Current methods fail adequately account the numerous factors impacting productivity do not reliably optimize prediction accuracy convergence speed. This paper puts forth a hybrid MLP-FGWO-PSO...
Obesity stigmatization, defined as the social devaluation and denigration of individuals because their excess weight, represents a significant barrier to effective healthcare delivery. This study aimed investigate professionals' knowledge about obesity-related health impacts, attitudes regarding weight bias (negative or discriminatory toward with obesity), beliefs causes nature obesity. cross-sectional was conducted among professionals between Jan, 2024 Feb, in The Department General...
Despite the initial response to reversible, ATP-competitive quinazoline inhibitors that target ErbB-family, such a subset of cancer patients almost invariably develop resistance. Recent studies have provided compelling evidence irreversible ErbB potential override this Here, we found AST1306, novel anilino-quinazoline compound, inhibited enzymatic activities wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well EGFR resistant mutant in both cell-free cell-based systems....
Abstract Myopia, which prevalence is rapidly increasing, causes visual impairment; however, the onset mechanism of pathological axial length (AL) elongation remains unclear. A highly vascularized choroid between retinal pigment epithelium (RPE) and sclera not only maintains physiological activities, but also contributes to ocular development growth regulation. Vascular endothelial factor (VEGF) secreted from RPE essential for function maintenance choriocapillaris. Herein, we demonstrated...
Objective: Falls often occur in patients with diabetic neuropathy due to biomechanical alternation. The implication of peripheral (DPN) on gait and balance remains poorly understood. Methods: A total 11 dynamic gait, electrophysiological parameters were evaluated 176 participants. compared between groups. Results: Stride length stride velocity significantly lower all subgroups DPN healthy subjects (p< 0.05). Stance phase double support higher, but swing across than Under eyes-open standing,...
<h3>Background:</h3> Vardenafil is a new phosphodiesterase-5 inhibitor that has shown some efficacy in the treatment of pulmonary arterial hypertension (PAH). <h3>Objective:</h3> To examine long-term effects vardenafil patients with PAH. <h3>Methods:</h3> A multicentre, open-label study 1-year's duration was undertaken 45 PAH to determine safety and (5 mg once daily for first 4 weeks, then 5 twice daily) make preliminary assessment its monthly acquisition cost compared other PAH-active...
Aims . To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring progression in patients with diabetic foot ulcer (DFU). Methods A retrospective study was designed to the utility of estimating DFU admitted our hospital between January 2015 2016. In total, 152 were enrolled group, 52 age gender matched people diabetes but no included as control group. assessed using Wagner criteria. Results Patients divided into 2 subgroups based on Mean...
The prevalence of myopia has been increasing in recent years. natural carotenoid crocetin reported to suppress experimental mice. We evaluated the effects on suppression children. A multicenter randomized double-blind placebo-controlled clinical trial was performed with 69 participants aged 6 12 years, whose cycloplegic spherical equivalent refractions (SER) were between −1.5 and −4.5 diopter (D). receive either a placebo or followed up for 24 weeks. Axial length (AL) elongation changes SER...