A5104688582- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Inflammatory Bowel Disease
- Microscopic Colitis
- Cell death mechanisms and regulation
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Immune Response and Inflammation
- Cancer Research and Treatments
- Microtubule and mitosis dynamics
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Adolescent Sexual and Reproductive Health
- Cancer, Lipids, and Metabolism
- Gastrointestinal motility and disorders
- Advanced Proteomics Techniques and Applications
European Atherosclerosis Society
2021
Elkem (Norway)
2021
Inserm
2006-2018
Université de Bourgogne
2003-2018
Université Bourgogne Franche-Comté
2018
Centre de recherche Translationnelle en Médecine moléculaire
2000-2016
Université des Sciences de la Santé
2015
Fondation de l'Avenir
2010-2011
Brigham and Women's Hospital
2010
Université de Montréal
1982-2007
Abstract Myeloid-derived suppressor cells (MDSC) accumulate in the spleen and tumor bed during growth. They contribute to immune tolerance of cancer notably by inhibiting function CD8(+) T cells. Thus, their elimination may hamper growth enhancing antitumor T-cell functions. We have previously reported that some anticancer agents relied on cell–dependent responses achieve maximal efficacy. However, effect MDSC has remained largely unexplored. In this study, we observed gemcitabine...
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid with the ability to suppress T cell activation. They accumulate tumor-bearing shown contribute cancer development. Here, we isolated tumor-derived exosomes (TDEs) from mouse lines that an interaction between TDE-associated Hsp72 MDSCs determines suppressive activity via activation Stat3. In addition, soluble factors triggered MDSC expansion Erk. Stat3 TLR2/MyD88-dependent...
Tumor growth promotes the expansion of CD4+CD25+ regulatory T (T reg) cells that counteract cell–mediated immune responses. An inverse correlation between natural killer (NK) cell activation and reg in tumor-bearing patients, shown here, prompted us to address role controlling innate antitumor immunity. Our experiments indicate human expressed membrane-bound transforming factor (TGF)–β, which directly inhibited NK effector functions down-regulated NKG2D receptors on surface. Adoptive...
We investigated the mechanisms of immune tolerance raised by tumors comparing immunogenic and tolerogenic tumor cell clones isolated from a rat colon carcinoma. When injected into syngeneichosts, REGb cells yield that are rejected, while PROb progressive inhibit regression tumors. show here volume is correlated with an expansion CD4(+)CD25(+) regulatory T lymphocytes in lymphoid tissues. These delay vivo rejection vitro cell-mediated responses against through mechanism requires contact...
The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation CD4+CD25+ (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function originates from proliferation naturally occurring CD25+ requires signaling transforming growth factor (TGF)–β receptor II. During tumor progression, a subset dendritic (DCs) myeloid immature phenotype is recruited to draining lymph nodes. This DC...
Corticosteroids are the most efficacious drugs for inducing remission in active Crohn's disease, but their benefits frequently offset by serious side effects. Budesonide is a corticosteroid with high topical antiinflammatory activity low systemic because of extensive hepatic metabolism. We investigated efficacy and safety an oral controlled-ileal-release preparation budesonide patients disease involving ileum or proximal colon.
Abstract Purpose: T-cell infiltration is associated with good tumor prognosis in many cancers. To assess the capacity of neoadjuvant chemotherapy to affect breast cancer, we evaluated CD3 and CD8 infiltrates, Foxp3 immunosuppressive T cells. Experimental Design: CD3+, CD8+, Foxp3+ cell infiltrates were detected by immunohistochemistry a series 56 cancer patients before after end chemotherapy. Results: Poor prognostic factors (negative hormonal receptors, high grade, nodal involvement)...
Tumor-infiltrating T and B lymphocytes could have the potential to affect cancer prognosis. The objective of this study was investigate prognostic significance tumor infiltration by CD8 CD4 cells, in patients with localized gastric cancer. In a retrospective cohort 82 treated surgery we quantitatively assessed immunohistochemistry on surgical specimen, immune infiltrates IL-17+, CD8+, Foxp3+, Tbet+ cells CD20+ both core at invasive margin via immunohistochemical analyses specimens. We...
Background: Chemotherapy is currently evaluated in order to enhance the efficacy of immune checkpoint blockade (ICB) therapy colorectal cancer. However, mechanisms by which these drugs could synergize with ICB remains unclear. The impact chemotherapy on PD-1/PD-L1 pathway and resulting anticancer responses was assessed two mouse models cancer validated tumor samples from metastatic patients that received neoadjuvant treatment. We demonstrated 5-Fluorouracil plus Oxaliplatin (Folfox) drove...
Background: The transmembrane receptor Fas, together with its protein-binding partner (Fas ligand), is a key regulator of programmed cell death (i.e., apoptosis). Fas and ligand also influence the ability cytotoxic T lymphocytes natural killer cells to eliminate tumor cells. However, by inducing apoptosis in activated cells, Fas/Fas system may protect some from clearance immune system. Anticancer drugs enhance expression on surface receptor-expressing leukemia thus suggesting that caused...
Abstract Cancer chemotherapy can induce tumor regression followed, in many cases, by relapse the long‐term. Thus this study was performed to assess determinants of such phenomenon using an vivo cancer model and vitro approaches. When animals bearing established are treated cisplatin, initially undergoes a dramatic shrinkage is characterized giant cells that do not proliferate but maintain DNA synthesis. After several weeks latency, resumes its progression consists small proliferating cells....
Abstract Accumulating preclinical evidence suggests that anticancer immune responses contribute to the success of chemotherapy. However, predictive value tumour‐infiltrating lymphocytes after neoadjuvant chemotherapy for breast cancer remains unknown. We hypothesized nature infiltrate following would predict patient survival. In a series 111 consecutive HER2‐ and 51 non‐HER2‐overexpressing patients treated by chemotherapy, we studied immunohistochemistry tumour infiltration FOXP3 CD8 T...
From an established cell culture line obtained from a chemically-induced rat colon carcinoma, two sublines have been selected and isolated according to their susceptibility trypsin-mediated detachment plastic surfaces. Subline TR, the most resistant detaching effect of trypsin, gave progressive tumors in syngeneic rats which it was inoculated. TS, easily detached by also rats, but all these disappeared within 3 or 4 weeks. Both when injected into nude mice. This suggests that parent is...
Abstract In various cell systems, an inverse relationship was found between expression of E‐cadherin, a molecule involved in the Ca 2+ ‐dependent homophylic cell‐to‐cell attachment epithelial cells, and capacity to invade extracellular matrix gels or normal tissues vitro. , DHD/K12/TRb (PROb) maintained as line derived from rat colon carcinoma, homogeneously expressed. vitro immunoreactive which functional shown dissociation‐reassociation assays. PROb cells were be non‐invasive 3 different...