Diagnostic criteria for multiple sclerosis have been developed to guide the diagnostic process. In latest revision of McDonald criteria, presence oligoclonal bands may replace need dissemination in time. The aim this study is investigate if less time-consuming analysis immunoglobulin G index cerebrospinal fluid can safely predict findings bands.This a retrospective patients with at three hospitals South-East Norway where lumbar puncture performed routinely. We included diagnosed after 2005...

Hepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution other aetiological causes CLD less well documented and hence opportunities modulate potential risk factors are being lost. aims this study were explore spectrum eastern Ethiopia identify plausible underlying for its development.A cross-sectional was undertaken between April 2015 2016 two public hospitals Harar, Ethiopia. population comprised consenting...

Biomarkers may facilitate clinical decisions in order to guide antimicrobial treatment and prediction of prognosis community-acquired pneumonia (CAP). We measured serum C-reactive protein, procalcitonin (PCT) calprotectin levels, plasma pentraxin 3 (PTX3) presepsin along with whole-blood white cell counts, at three time-points, examined their association microbial aetiology adverse outcomes CAP.Blood samples were obtained hospital admission, stabilisation 6-week follow-up from 267...

Self-perceived statin-associated muscle symptoms (SAMS) are prevalent, but only a minority is drug-dependent. Diagnostic biomarkers not yet identified. The local statin exposure in skeletal tissue may correlate to the adverse effects. We aimed determine whether atorvastatin metabolites blood reflect corresponding metabolite levels muscle, and genetic variants of transporters modulate this relationship. also addressed as potential objective SAMS. Muscle were examined patients with coronary...

Statin-associated muscle symptoms (SAMS) is a prevalent cause of statin discontinuation. It challenging and time-consuming for clinicians to assess whether are caused by the or not, diagnostic biomarkers requested. Atorvastatin metabolites have been associated with SAMS. We aimed compare atorvastatin pharmacokinetics between coronary heart disease (CHD) patients without clinically intolerance statin-dependent histopathological alterations in tissue. Secondarily we genetic variants relevant...

The serum bone turnover markers (BTM) procollagen type 1 N-terminal propeptide (P1NP) and C-terminal cross-linking telopeptide of collagen (CTX) are recommended for monitoring adherence response antiresorptive drugs (ARD). BTM elevated about year after fracture therefore target values most convenient in ARD treatment follow-up patients. In this prospective cohort study, we explored the cut-off P1NP CTX showing best discriminating ability with respect to effects, reflected mineral density...

Introduction. Self-monitoring of blood glucose (SMBG) is important in diabetes management. Reliable and user-friendly instruments are essential. OneTouch Verio® a new concentration-measuring system designed to be used by patients with healthcare professionals. The objective the present study was evaluate analytical performance Verio®. Method. evaluated Scandinavian evaluation laboratory equipment for primary (SKUP) according protocol based on ISO 15197 American Diabetes Association (ADA)...

Objective: Faecal (f-) calprotectin is a widely used surrogate marker of intestinal inflammation. F-calprotectin analysis labour demanding partly due to time consuming extraction step. The aim this project was validate new method for f-calprotectin. Material and methods: A prospective multicentre study included 135 patients with an established diagnosis inflammatory bowel disease. submitted faeces sample, which extracted both the conventional at participating laboratory device. extracts were...

Faecal (f-) calprotectin is a widely used marker for intestinal inflammation. However, extraction procedure time consuming and cumbersome. The main aim of this study was to evaluate patient-performed f-calprotectin compared performed in the laboratory.A total 81 adult patients with an established diagnosis inflammatory bowel disease provided two samples from same movement, one conventional faeces sample patient administered device. A laboratory technician extracted device.F-calprotectin...

Abstract Background Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability a human antimicrobial defense mechanism. We explored iron-related proteins as potential biomarkers in community-acquired pneumonia hypothesized that infection-induced changes these differ between groups pathogens could predict microbial etiology. Methods Blood samples from prospective cohort 267 patients with were analyzed hepcidin, ferritin, iron, transferrin, soluble...

Abstract Background Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in mevalonate biosynthesis pathway. By this mechanism, synthesis of cholesterol is reduced as well isoprenoid intermediates, which are essential to isoprenylation several proteins. Decreased protein has been suggested a potential pathophysiological mechanism statin intolerance, but in-vivo studies remain be conducted. Purpose To assess whether levels blood plasma, response atorvastatin treatment, associated with...

Abstract Statin‐associated muscle symptoms are frequently reported and often lead to discontinuation of statin therapy with an increased risk cardiovascular events. In vitro studies suggest that statin‐mediated inhibition the mevalonate pathway leads cell toxicity. We aimed determine relationship between mevalonate, LDL‐cholesterol, atorvastatin metabolites in patients coronary heart disease self‐perceived side effects. Furthermore, we assessed correlation blood intolerance due symptoms....

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): Vestre Viken Hospital Trust. Background In clinical practice, it is challenging and time-consuming to assess whether self-perceived statin associated muscle symptoms (SAMS) are caused by the or not, diagnostic biomarkers therefore requested [1]. Atorvastatin (ATV) metabolites, especially lactones, have been with dependent muscular side effects [2, 3]. Purpose To ATV metabolites as potential for in...

Background . Recent studies have identified chewing of khat ( Catha edulis ) as an independent risk factor for liver injury; however, the pathogenetic mechanism remains poorly understood. Case series found markers autoimmune hepatitis in patients with khat-related disease, suggesting that might trigger response. The aims present study were (i) to assess prevalence autoantibodies typical diseases a healthy population Ethiopia and (ii) explore hypothesis usage triggers autoimmunity. Methods...

<b>Background:</b> Biomarkers are helpful tools to aid clinical decision-making in community-acquired pneumonia (CAP) through identification of microbial etiology and severe outcome, but there is a need for clarification the most useful biomarker(s) cut-off levels best significance. We measured five biomarkers examined their association with etiology, disease severity short-term outcome CAP. <b>Methods:</b> C-reactive protein (CRP), procalcitonin (PCT), pentraxin 3 (PTX3), soluble triggering...

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): The Dam foundation Introduction Statin non-adherence remains a prevalent challenge in cardiovascular disease prevention and robust methods to monitor adherence are needed. Large variations low-density-lipoprotein cholesterol (LDL-C) response given type dose statin have been reported. LDL-C short-term discontinuation statins is not well defined. Moreover, the relationship between blood concentrations...

Abstract Funding Acknowledgements Type of funding sources: Public hospital(s). Main source(s): Vestre Viken Hospital Trust Background Statin-associated muscle symptoms (SAMS) cover a broader range clinical presentations, with normal or mildly elevated creatine kinase (CK) in blood, and is prevalent challenge practice. Our understanding the pathophysiology SAMS remains largely unknown. Purpose To gain new knowledge on molecular effects atorvastatin plasma blood cells patients coronary heart...