A5072036594- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Autoimmune and Inflammatory Disorders
- Gastroesophageal reflux and treatments
- Celiac Disease Research and Management
- Digestive system and related health
- Health Systems, Economic Evaluations, Quality of Life
- Biomarkers in Disease Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- Pelvic floor disorders treatments
- Pharmaceutical studies and practices
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Healthcare cost, quality, practices
- Education, Healthcare and Sociology Research
- Dysphagia Assessment and Management
- Colorectal Cancer Surgical Treatments
- Adolescent and Pediatric Healthcare
- Organ Donation and Transplantation
- Mycobacterium research and diagnosis
- Clinical Nutrition and Gastroenterology
Oslo University Hospital
2017-2025
University of Oslo
2014-2025
Lovisenberg Diakonale Sykehus
2014-2023
Sorbonne Université
2015
Centre Hospitalier Universitaire Amiens-Picardie
2015
Hôpital Saint-Antoine
2015
As mucosal healing is the goal of treatment in inflammatory bowel disease, defining a fecal [f-] calprotectin cut-off level for crucial. Previous studies have presented different levels. The aim this study was to investigate ability two f-calprotectin assays differentiate from inflammation ulcerative colitis.Sixty-two patients with colitis underwent colonoscopy classification [Mayo endoscopic subscore]. also submitted sample analysis using assays, Calpro ELISA and Buhlmann ELISA.The...
Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim this study was to compare dietary intakes nutritional status men women newly diagnosed IBD a general population sample, investigate whether were line the Nordic Nutrition Recommendations. Methods: This cross-sectional including adults≥ 40 years from Inflammatory Bowel Disease South-Eastern Norway (IBSEN) III cohort...
Abstract Background Despite the well-established involvement of gut microbiota in inflammatory bowel disease (IBD), little is known about how changes over time or it varies with clinical activity and faecal calprotectin. To address this gap, we utilized population-based inception cohort IBSEN III. Methods Stool samples from IBD patients symptomatic controls (SC) were collected at diagnosis after 3, 6, 12 months. Comprehensive data collection was performed baseline 12-month follow-up, while...
Abstract Background Multiple alterations in the immune repertoire of IBD patients have been identified including, an expansion a subset type II natural killer T cells CD patients, termed Crohn’s-associated invariant (CAIT)1. Previously, we showed that CAIT respond to small molecules resemble multiple microbial and drug metabolites2. This begs question whether are expanded due ongoing disease or medications administrated control disease. Methods We profiled cell receptor alpha chain 246...
Abstract Background The kynurenine pathway is upregulated in inflammatory bowel disease (IBD) a disease-activity induced manner. This route of tryptophan (Trp) degradation leads to variety bioactive compounds, including several with anti-inflammatory (e.g., kynurenic acid (Kyna), xanthurenic (Xana)) or cytotoxic (quinolinic (Quin)) effects. Our aim was stratify patients IBD into distinct subgroups based on their Trp metabolic profiles (Trp metabotypes) and assess prognostic capacity...
Abstract Background Fatigue is common in both Crohn's disease (CD) and ulcerative colitis (UC), but the pathogenesis still unclear. The primary aim of this study was to assess odds for substantial fatigue (SF) chronic (CF) one year after diagnosis based on presence SF at baseline. secondary identify clinical factors that may be associated with diagnosis. Methods Patients ≥18 years a definite CD or UC 1-year follow-up were recruited from Inflammatory Bowel Disease South-Eastern Norway (IBSEN...
Abstract Background Distinguishing irritable bowel syndrome (IBS) from inflammatory disease (IBD) flare-ups is challenging. This study used objective remission markers to accurately determine IBS prevalence in a population-based cohort of patients with IBD. Methods Adults ulcerative colitis and Crohn’s were recruited the IBD South-Eastern Norway III study. Irritable bowel-like symptoms assessed using Rome IV criteria for at 1- 3-year follow-ups. Remission was defined objectively biochemical...
Objective Faecal (f-) calprotectin is a biomarker of intestinal inflammation. Previous studies have described intra-individual day-to-day variability this in patients with inflammatory bowel disease (IBD) and morning samples been suggested for standardisation purposes. With project, we investigated if differed from diurnal variability. Additionally, evaluated new extraction method f-calprotectin analysis. Methods Fifty provided three faeces – evening on two consecutive days. Nineteen the...
Abstract Background Patients with inflammatory bowel disease report multiple symptoms, but the relationships among co-occurring symptoms are poorly understood. This study aimed to examine prevalence of and explore symptom clusters possible associations between socio-demographic clinical variables in patients newly diagnosed disease. Methods The IBSEN III is a prospective population-based inception cohort used patient data from three largest hospitals catchment area. Memorial Symptom...
Mucosal healing has become the new goal of treatment in ulcerative colitis. Fecal calprotectin been demonstrated to differentiate between mucosal inflammation and healing. With this project, we investigated whether a reduction f-calprotectin <250 μg/g after medical for active colitis could predict After baseline colonoscopy, 20 patients with were followed consecutive fecal monthly until two measurements < 250 or maximum follow-up 12 months. A flexible sigmoidoscopy was then performed Mayo...
Abstract Background and Aims Although fatigue is common in inflammatory bowel disease [IBD], its pathogenesis remains unclear. This study aimed to determine the prevalence of associated factors a cohort patients newly diagnosed with IBD. Methods Patients ≥18 years old were recruited from Inflammatory Bowel Disease South-Eastern Norway [IBSEN III] study, population-based, observational inception cohort. Fatigue was assessed using Questionnaire compared data Norwegian general population....
Summary Background The introduction of biologic therapies and the ‘treat‐to‐target’ treatment strategy may have changed disease course ulcerative colitis (UC). Aims To describe early outcome at 1‐year follow‐up in a population‐based inception cohort adult patients with newly diagnosed UC. Methods Inflammatory Bowel Disease South‐Eastern Norway (IBSEN) III study is prospective follow‐up. Patients inflammatory bowel during 2017–2019 were included. ≥18 years diagnosis UC who attended...
Background and aim Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural course. Inception cohort studies gold standard investigating such changes. We have initiated a new population-based inception study; Inflammatory in South Eastern Norway III (IBSEN III). In this article, we describe study protocol baseline characteristics of cohort.Methods IBSEN is an ongoing, observational with prospective follow-up. Adult pediatric patients suspected IBD...
Introduction: Patients with coeliac disease commonly report symptoms of 'brain fog'. The aim this study was to assess self-reported impaired concentration in before and after treatment gluten-free diet, compared healthy controls patient controls.Methods: newly diagnosed were included consecutively from two out-patient clinics. patients completed the questionnaires Adult ADHD Self-Report Scale v1.1 Symptoms Checklist (ASRS), Hospital Anxiety Depression (HADS) Gastrointestinal Symptom Rating...
Abstract Background The present study aimed to estimate the prevalence of irritable bowel syndrome [IBS] symptoms and associated variables in a prospective cohort patients with inflammatory disease [IBD] remission one year after diagnosis. Methods Adult [≥18 years old] ulcerative colitis [UC] Crohn’s [CD] were recruited from Inflammatory Bowel Disease South-Eastern Norway [IBSEN] III study, population-based inception cohort. IBS-like was assessed using Rome IV criteria for their IBD...
Crohn's disease (CD) is a clinical subset of inflammatory bowel that characterized by patchy transmural inflammation across the gastrointestinal tract. Although exact etiology remains unknown, recent findings suggest it complex multifactorial with contributions from host genetics and environmental factors such as microbiome. We have shown T cell repertoire CD patients harbors group highly expanded cells which hints toward an antigen-mediated pathology. To profile immunological signature at...
Abstract Purpose This unselected, population-based cohort study aimed to determine the level of health-related quality life (HRQoL) in patients with Crohn’s disease (CD) and ulcerative colitis (UC) at time diagnosis compared a reference population identify demographic factors, psychosocial measures, activity markers associated HRQoL. Methods Adult newly diagnosed CD or UC were prospectively enrolled. HRQoL was measured using Short Form 36 (SF-36) Norwegian Inflammatory Bowel Disease...
Objective: Faecal (f-) calprotectin is a widely used surrogate marker of intestinal inflammation. F-calprotectin analysis labour demanding partly due to time consuming extraction step. The aim this project was validate new method for f-calprotectin. Material and methods: A prospective multicentre study included 135 patients with an established diagnosis inflammatory bowel disease. submitted faeces sample, which extracted both the conventional at participating laboratory device. extracts were...
Background and aims Peroral endoscopic myotomy (POEM) is an established therapy for achalasia, but outcome evaluation has often been limited to Eckardt score (ES). The present study was aimed improve knowledge about predictive factors by performing a comprehensive objective of achalasia patients treated POEM.Methods This single centre prospective reports data 12 months after POEM in treatment-naive patients. A predefined follow-up protocol included ES, high resolution manometry, 24-h pH...
Abstract Background and aims The functional luminal imaging probe (FLIP) can provide measurements of lower esophageal sphincter (LES) distensibility. Studies report that use intraoperative FLIP examination during peroral endoscopic myotomy (POEM) for achalasia is associated with treatment success, but evidence limited inconsistent. main aim the present study was to assess associations between values 1-year outcomes. Additionally, other outcome variables were studied. Methods We performed a...
Faecal (f-) calprotectin is a widely used marker for intestinal inflammation. However, extraction procedure time consuming and cumbersome. The main aim of this study was to evaluate patient-performed f-calprotectin compared performed in the laboratory.A total 81 adult patients with an established diagnosis inflammatory bowel disease provided two samples from same movement, one conventional faeces sample patient administered device. A laboratory technician extracted device.F-calprotectin...
Introduction: Serological antibodies have been associated with complicated disease course in Crohn's (CD), including the need for surgery.Aim: The aim of this study was to investigate if a panel relevant could predict surgery prospective population-based cohort patients CD.Methods: IBSEN has followed prospectively 20 years. At 10- and 20-year follow-up, following serological analysed: pANCA, ASCA IgA, IgG, anti-OmpC, anti-I2, anti-CBir1. follow-up or until lost all CD-related surgeries were...