A5081615653- Inflammatory Bowel Disease
- Microscopic Colitis
- Pregnancy and Medication Impact
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Reproductive System and Pregnancy
- Lung Cancer Diagnosis and Treatment
- Gut microbiota and health
- Biomarkers in Disease Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Health disparities and outcomes
- Health, psychology, and well-being
- Celiac Disease Research and Management
- Effects of Radiation Exposure
- Head and Neck Cancer Studies
- Climate Change and Health Impacts
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and preeclampsia studies
- Dietary Effects on Health
- Radiomics and Machine Learning in Medical Imaging
- Infant Nutrition and Health
- Autoimmune and Inflammatory Disorders
- Helicobacter pylori-related gastroenterology studies
Sykehuset i Vestfold
2016-2025
Akershus University Hospital
2017-2023
University of Oslo
2017-2020
Patients with inflammatory bowel disease [IBD] often suffer from rheumatic manifestations, including back disorders. The prevalence of these disorders late in the course IBD is poorly investigated. aim this study was to estimate patients 20 years after diagnosis, and investigate possible associations severity, HLA-B27, NOD2 genotype.A population-based cohort [the IBSEN study] followed prospectively for years. Information covering activity diseases collected at regular follow-ups. HLA-B27...
Background: Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim this study was to compare dietary intakes nutritional status men women newly diagnosed IBD a general population sample, investigate whether were line the Nordic Nutrition Recommendations. Methods: This cross-sectional including adults≥ 40 years from Inflammatory Bowel Disease South-Eastern Norway (IBSEN) III cohort...
Abstract Background Despite the well-established involvement of gut microbiota in inflammatory bowel disease (IBD), little is known about how changes over time or it varies with clinical activity and faecal calprotectin. To address this gap, we utilized population-based inception cohort IBSEN III. Methods Stool samples from IBD patients symptomatic controls (SC) were collected at diagnosis after 3, 6, 12 months. Comprehensive data collection was performed baseline 12-month follow-up, while...
Abstract Background Multiple alterations in the immune repertoire of IBD patients have been identified including, an expansion a subset type II natural killer T cells CD patients, termed Crohn’s-associated invariant (CAIT)1. Previously, we showed that CAIT respond to small molecules resemble multiple microbial and drug metabolites2. This begs question whether are expanded due ongoing disease or medications administrated control disease. Methods We profiled cell receptor alpha chain 246...
Abstract Background The kynurenine pathway is upregulated in inflammatory bowel disease (IBD) a disease-activity induced manner. This route of tryptophan (Trp) degradation leads to variety bioactive compounds, including several with anti-inflammatory (e.g., kynurenic acid (Kyna), xanthurenic (Xana)) or cytotoxic (quinolinic (Quin)) effects. Our aim was stratify patients IBD into distinct subgroups based on their Trp metabolic profiles (Trp metabotypes) and assess prognostic capacity...
Abstract Background Fatigue is common in both Crohn's disease (CD) and ulcerative colitis (UC), but the pathogenesis still unclear. The primary aim of this study was to assess odds for substantial fatigue (SF) chronic (CF) one year after diagnosis based on presence SF at baseline. secondary identify clinical factors that may be associated with diagnosis. Methods Patients ≥18 years a definite CD or UC 1-year follow-up were recruited from Inflammatory Bowel Disease South-Eastern Norway (IBSEN...
Abstract Background Distinguishing irritable bowel syndrome (IBS) from inflammatory disease (IBD) flare-ups is challenging. This study used objective remission markers to accurately determine IBS prevalence in a population-based cohort of patients with IBD. Methods Adults ulcerative colitis and Crohn’s were recruited the IBD South-Eastern Norway III study. Irritable bowel-like symptoms assessed using Rome IV criteria for at 1- 3-year follow-ups. Remission was defined objectively biochemical...
The aims of this study were to explore the influences familial, maternal, and paternal inflammatory disease (IBD) on perinatal outcomes in offspring risk for development IBD related factors.Eighty-five patients with Crohn's (CD) 86 ulcerative colitis (UC) included from a population-based incidence enrolled 1990-1994. Family birth records these patients, as well their 207 infants, drawn Norwegian Medical Birth Registry, established 1967, compared national cohort same period.Maternal (odds...
Abstract Background Patients with inflammatory bowel disease report multiple symptoms, but the relationships among co-occurring symptoms are poorly understood. This study aimed to examine prevalence of and explore symptom clusters possible associations between socio-demographic clinical variables in patients newly diagnosed disease. Methods The IBSEN III is a prospective population-based inception cohort used patient data from three largest hospitals catchment area. Memorial Symptom...
Environmental and genetic factors contribute to variation in irritable bowel syndrome (IBS), anxiety depression. Comorbidity between these disorders is high. A previous investigation of our population-based twin cohort revealed that low birth weight increased the risk for development IBS, with environmental influences utero as most relevant contributing factor. We hypothesise both intrauterine influence co-occurrence IBS symptoms postal questionnaire sent 12700 Norwegian twins born 1967 1979...
Patients with inflammatory bowel disease (IBD) are in general prone to weight loss. We explored the risk of inadequate gestational gain (GWG), and impact GWG on adverse pregnancy outcomes, among mothers IBD Norwegian Mother Child Cohort Study (MoBa). The MoBa 95,200 enrolled from 1999 2008, comprised 217 ulcerative colitis 166 Crohn's disease. Demographics were ascertained through a basic questionnaire before first ultrasound visit an history activity during mailed out 2013. Inadequate was...
Abstract Background and Aims Although fatigue is common in inflammatory bowel disease [IBD], its pathogenesis remains unclear. This study aimed to determine the prevalence of associated factors a cohort patients newly diagnosed with IBD. Methods Patients ≥18 years old were recruited from Inflammatory Bowel Disease South-Eastern Norway [IBSEN III] study, population-based, observational inception cohort. Fatigue was assessed using Questionnaire compared data Norwegian general population....
To explore the change in risk among 1st degree relatives of ulcerative colitis (UC) and Crohn's disease (CD) for development concordant an incidence cohort followed ten years. Furthermore, we wanted to compare familial sporadic cases regarding clinical characteristics course disease.This population-based study included 421 patients with UC 197 CD enrolled from 1990 1994. Clinical number were recorded continuously during years.Age at diagnosis (OR=0.95, 95% CI: 0.93-0.98) cumulative relapse...
The development of both chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is influenced by smoking related inflammation caused an excessive innate immune response to smoke exposure. In addition, the induced formation covalent bonds between carcinogens DNA accumulation permanent somatic mutations in critical genes are important carcinogenic processes, can also induce inflammatory responses. How mirrored serum markers COPD LC if these reflect prognosis patients with is,...
Summary Background The introduction of biologic therapies and the ‘treat‐to‐target’ treatment strategy may have changed disease course ulcerative colitis (UC). Aims To describe early outcome at 1‐year follow‐up in a population‐based inception cohort adult patients with newly diagnosed UC. Methods Inflammatory Bowel Disease South‐Eastern Norway (IBSEN) III study is prospective follow‐up. Patients inflammatory bowel during 2017–2019 were included. ≥18 years diagnosis UC who attended...
The purpose was to study the spatial distribution of cases inflammatory bowel disease (IBD) and characterize municipalities with high incidences in a search for environmental risk factors.Spatial clustering patients diagnosed IBD during 1990-1993 were studied 4 counties southeastern Norway, an ecological analysis conducted relationship between their characteristics such as population, health care, urban/rural change, socioeconomic change.One cluster consisting identified Østfold county (P =...
Journal Article Concordance for IBD among twins compared to ordinary siblings — A Norwegian population-based study Get access May-Bente Bengtson, Bengtson * aMedical Department, Tonsberg County Hospital, Tonsberg, Norway *Corresponding author. Lokesvei 10, Åsgårdstand 3179, Norway. Tel.: +47 93236365, 33 049241 (home); fax: 343949. Search other works by this author on: Oxford Academic PubMed Google Scholar Geir Aamodt, Aamodt bThe Institute of Public Health, Oslo, Morten H. Vatn, Vatn...
The aim was to compare clustering of time at diagnosis and phenotype inflammatory bowel disease (IBD) between affected parents children explore generational differences in age (AAD) as well the concordance clinical characteristics. Eighty-four pairs from 45 families were included 5 counties southeastern Norway August 2003 December 2006; 43 sib-sib 39 parent-child pairs. Clinical data obtained by phone interviews hospital records. difference median AAD 17.0 years (P < 0.001) 2.0 = 0.29)...
Incidence and prevalence of ulcerative colitis follow a north-south (latitudinal) gradient increases northwards at the northern hemisphere or southwards southern hemisphere. The disease has increased during last decades. temporal trend been explained by hygiene hypothesis, but few parallel explanations exist for spatial variability. Many factors are linked to latitude such as climate. Our purpose was investigate association between variables governing climate prospectively identified...
The present study explores changes in pulmonary function, symptoms and radiological signs of pneumonitis after curatively intended stereotactic body radiation therapy (SBRT). All inoperable, early-stage non-small cell lung cancer patients treated with (SBRT) from 2014-2017 were included this single-centre study. They followed regularly for 12 months treatment. classified into three groups based on radiology symptomatology: no pneumonitis, asymptomatic symptomatic pneumonitis. Forty-four...
Background and aim Modern treatment strategies for inflammatory bowel disease (IBD) are postulated to change the natural course. Inception cohort studies gold standard investigating such changes. We have initiated a new population-based inception study; Inflammatory in South Eastern Norway III (IBSEN III). In this article, we describe study protocol baseline characteristics of cohort.Methods IBSEN is an ongoing, observational with prospective follow-up. Adult pediatric patients suspected IBD...