A5066041617- Lipoproteins and Cardiovascular Health
- Gastrointestinal motility and disorders
- Pharmaceutical Economics and Policy
- Cardiac Health and Mental Health
- Diet and metabolism studies
- Medication Adherence and Compliance
- Pneumonia and Respiratory Infections
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Acute Myocardial Infarction Research
- Plant biochemistry and biosynthesis
- Congenital gastrointestinal and neural anomalies
- Respiratory viral infections research
- Smoking Behavior and Cessation
- Emergency and Acute Care Studies
- Hemoglobinopathies and Related Disorders
- Gut microbiota and health
- Iron Metabolism and Disorders
- Blood Pressure and Hypertension Studies
- Biosimilars and Bioanalytical Methods
- Esophageal and GI Pathology
- Infant Health and Development
- Cystic Fibrosis Research Advances
Drammen Hospital
2016-2025
Vestre Viken Hospital Trust
2016-2025
University of Oslo
1990-2019
Oslo University Hospital
1990-2010
Norwegian Medical Association
2009
University Hospital Ulm
2006
National Hospital
2001
Norwegian Cancer Society
1991-1995
Karolinska Institutet
1994
The effect of an intestinal microflora consisting selected microbial species on myoelectric activity small intestine was studied using germ-free rat models, with recording before and after specific colonization, in the unanesthetized state. Intestinal transit, neuropeptides blood (RIA), neuromessengers wall were determined. Clostridium tabificum vp 04 promoted regular spike burst activity, shown by a reduction migrating complex (MMC) period from 30.5 ± 3.9 min state to 21.2 0.14 ( P <...
Despite recent advances in microbiological techniques, the etiology of community-acquired pneumonia (CAP) is still not well described. We applied polymerase chain reaction (PCR) and conventional methods to describe CAP hospitalized adults evaluated their respective diagnostic yields. 267 patients were enrolled consecutively over our 3-year prospective study. Conventional (i.e., bacterial cultures, urinary antigen assays, serology) combined with nasopharyngeal (NP) oropharyngeal (OP) swab...
For each of several individuals a sequence repeated events, forming renewal process, is observed up to some censoring time. The object estimate the average interevent time over population as well variation times within and between individuals. Medical motivation comes from gastroenterology, concerns occurrence certain cyclic movements in small bowel during fasting state. Two statistical models are considered: one standard variance component model adapted censored data, other recent intensity...
Background Contributors to long-term mortality in patients with community-acquired pneumonia (CAP) remain unclear, little attention paid etiology. We examined survival, causes of death, and risk factors for adult who had been hospitalized CAP, emphasis on demographic, clinical, laboratory, microbiological characteristics. Methods Two hundred sixty-seven consecutive admitted 2008–2011 a general hospital CAP were prospectively recruited followed up. Patients died during stay excluded....
Intestinal disorders suggesting impaired gastrointestinal motility due to aging have been reported, but the influence of advanced age on patterns in human small intestine is unknown. The present prospective study describes these 15 healthy old subjects with a median 84 years (range, 81-91 years). Nineteen young adults served as controls. Ambulatory manometry was performed at home, two sensors located proximal intestine. Postprandial induced by standardized meal 1800 h, and fasting recorded...
Fifteen healthy old people mean age 84 years (range 80-91 years), were examined to assess the effect of advanced on microecology upper gastrointestinal tract. Twelve 15 (80%) hypochlorhydric with pH 6.6 (0.3) (mean (SEM) and a bacterial count 10(8) colony forming units (CFU) per ml 10(5)-10(10)) in fasting gastric aspirate. Normochlorhydric subjects had low counts (< or = 10(1) CFU/ml). The microbial flora was dominated by viridans streptococci, coagulase negative staphylococci, Haemophilus...
ABSTRACT Variability in low‐density lipoprotein cholesterol (LDL‐C) has emerged as a potential independent cardiovascular risk factor, but the impact of short‐term discontinuation statins on LDL‐C remains to be defined. Furthermore, relationship between individual statin metabolites and changes not yet been examined. The present study aimed investigate concentrations during four‐day atorvastatin therapy examine correlations half‐lives concentrations. This pharmacokinetic intervention...
An algorithm for the paracetamol absorption test gastric emptying, adjusting individual pharmacokinetics, was recently developed. The aim of present study to validate use this algorithm. Furthermore, applied elucidate whether a tube interferes with rate emptying. A caloric liquid meal administered orally nine healthy volunteers on two separate days. On one occasion, subjects were intubated nasogastric and aspirated from stomach 45 min after intake. percentage retained in at time aspiration...
Understanding the determinants of low-density lipoprotein cholesterol (LDL-C) control constitutes basis modelling interventions for optimal lipid and prognosis. We aim to identify medical psychosocial (study) factors associated with unfavourable LDL-C in coronary patients. A cross-sectional explorative study used logistic linear regression analysis investigate association between 1095 patients, hospitalized myocardial infarction and/or a revascularization procedure. Data were collected from...
Fecal calprotectin concentration in stool has recently been proposed as a marker of colonic neoplasm and inflammation, but the intraindividual day-to-day variability so far received little attention. The present study was undertaken to determine biological fecal patients referred for colonoscopy.A prospective design applied. In each 14 consecutive submitted colonoscopy, eight samples were collected before endoscopy. A detailed questionnaire used. Calprotectin measured by quantitative...
We present an approach for analyzing internal dependencies in counting processes. This covers the case with repeated events on each of a number individuals, and more generally, situation where several processes are observed individual. define dynamic covariates, i.e., covariates depending past The statistical analysis is performed mainly by nonparametric additive approach. yields method multivariate survival data, which alternative to frailty cumulative regression plots, tests, residual hat...
Objective An interleukin-beta antagonist reduces the risk of subsequent cardiovascular events in coronary patients with high-sensitivity C-reactive protein (hs-CRP) ≥2 mg/L. It remains to be defined how large population at inflammatory is, and what predictors elevated are. Methods A cross-sectional study investigated proportion hs-CRP (i.e. mg/L) respective demographic clinical 971 without concomitant diseases who had been hospitalized myocardial infarction (80%) and/or a revascularization...
Abstract Background The inflammatory response to community‐acquired pneumonia ( CAP ) is orchestrated through activation of cytokine networks and the complement system. We examined association multiple cytokines terminal complex TCC with microbial aetiology, disease severity short‐term outcome. Materials methods Plasma levels 27 were analysed in blood samples obtained at hospital admission, clinical stabilization 6‐week follow‐up from 247 hospitalized adults . Fourteen mediators included...
Biomarkers may facilitate clinical decisions in order to guide antimicrobial treatment and prediction of prognosis community-acquired pneumonia (CAP). We measured serum C-reactive protein, procalcitonin (PCT) calprotectin levels, plasma pentraxin 3 (PTX3) presepsin along with whole-blood white cell counts, at three time-points, examined their association microbial aetiology adverse outcomes CAP.Blood samples were obtained hospital admission, stabilisation 6-week follow-up from 267...
This project aims to identify socio-demographic, medical and psychosocial factors (study factors) associated with coronary risk control prognosis, test their impact in a representative sample of heart disease (CHD) patients.The first phase includes cross-sectional study designed explore the association between factor CHD patients. Data from hospital records, questionnaire, clinical examination blood samples were collected. The independent effects on subsequent events will be explored...
To estimate the effect of atorvastatin on muscle symptom intensity in coronary heart disease (CHD) patients with self-perceived statin-associated symptoms (SAMS) and to determine relationship blood levels and/or metabolites.A randomized multi-centre trial consecutively identified 982 previous or ongoing treatment after a CHD event. Of these, 97 (9.9%) reported SAMS 77 were 7-week double-blinded 40 mg/day placebo crossover design. The primary outcome was individual mean difference between...
Self-perceived statin-associated muscle symptoms (SAMS) are prevalent, but only a minority is drug-dependent. Diagnostic biomarkers not yet identified. The local statin exposure in skeletal tissue may correlate to the adverse effects. We aimed determine whether atorvastatin metabolites blood reflect corresponding metabolite levels muscle, and genetic variants of transporters modulate this relationship. also addressed as potential objective SAMS. Muscle were examined patients with coronary...
Statin-associated muscle symptoms (SAMS) is a prevalent cause of statin discontinuation. It challenging and time-consuming for clinicians to assess whether are caused by the or not, diagnostic biomarkers requested. Atorvastatin metabolites have been associated with SAMS. We aimed compare atorvastatin pharmacokinetics between coronary heart disease (CHD) patients without clinically intolerance statin-dependent histopathological alterations in tissue. Secondarily we genetic variants relevant...