A5047973294- Celiac Disease Research and Management
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Neuropeptides and Animal Physiology
- Neuroendocrine Tumor Research Advances
- Child Nutrition and Feeding Issues
- Gastrointestinal motility and disorders
- Digestive system and related health
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Autism Spectrum Disorder Research
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Infant Health and Development
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Antimicrobial Peptides and Activities
- Inhalation and Respiratory Drug Delivery
- Urticaria and Related Conditions
- Dietary Effects on Health
- Rabies epidemiology and control
University of Campania "Luigi Vanvitelli"
2007-2021
Palmerston North Hospital
2019
University of Naples Federico II
1991-2017
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi
2013
Azienda Ospedaliera G. Brotzu
2013
University of Cagliari
2003
University of Maryland, Baltimore
2003
Sapienza University of Rome
1977-1994
Policlinico Umberto I
1977-1985
Glostrup Hospital
1983
Somatostatin is produced by gastrointestinal endocrine cells that have long, nonluminal, cytoplasmic processes. Such processes terminate on other cell types, including gastrin-producing and hydrochloric acid-producing cells, whose functions are profoundly affected somatostatin. The findings suggest somatostatin control the of through local release peptide way Also, certain types similar prolongations, which may analogous (paracrine) regulatory functions.
Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected either celiac disease or wheat allergy. Given lack NCGS biomarker, there need for standardizing procedure leading diagnosis confirmation. In this paper we report experts’ recommendations on how diagnostic protocol should be performed confirmation NCGS. A full assess clinical response gluten-free diet...
Zonulin, a protein that modulates intestinal permeability, is upregulated in several autoimmune diseases and involved the pathogenesis of diabetes BB/Wor animal model disease. To verify association between serum zonulin levels vivo permeability patients with type 1 diabetes, both parameters were investigated different stages process. Forty-two percent (141 339) had abnormal levels, as compared age-matched control subjects. The increased correlated changes claudin-1, claudin-2, myosin IXB...
ABSTRACT Objectives: Intestinal permeability (IPT) was investigated in patients with autism as well their first‐degree relatives to investigate leaky gut hypothesis. Faecal calprotectin (FC) also measured autism, either or without gastrointestinal symptoms, and relatives. Patients Methods: IPT results, assessed by means of the lactulose/mannitol test, were compared adult child controls FC values. Results: A high percentage abnormal values found among (36.7%) (21.2%) normal subjects (4.8%)....
Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten. Gluten-sensitive individuals (GS) cannot tolerate gluten and may develop gastrointestinal symptoms similar to those in CD, but overall clinical picture generally less severe not accompanied concurrence tissue transglutaminase autoantibodies or comorbidities. By studying comparing mucosal expression genes associated with intestinal barrier function, as well innate adaptive immunity CD compared GS, we sought...
LFB1 (HNF-1/HNF-1 alpha/APF) and LFB3 (vHNF-1/HNF-1 beta) are two homeoproteins involved in the transcriptional regulation of several liver-specific genes. Both genes expressed polarized epithelia a wide range tissues, including liver, digestive tract kidney. We have analyzed expression pattern developing rat kidney by situ hybridization. Our results show that transcripts can be detected mesoderm-derived cells as soon they induced to differentiate into epithelium, while appear only at later...
Background: Intestinal permeability has seldom been investigated in diabetes mellitus, even though patients frequently report gastrointestinal symptoms, and it recently shown that the prevalence of celiac disease associated with mellitus is higher than expected. Methods: to cellobiose mannitol was 31 affected by type I uncomplicated mellitus. Values were compared those obtained 32 normal subjects. Results: The percentage recovery far two thirds correlated length disease, probes' ratio...
Purpose . Immune system of some autistic patients could be abnormally triggered by gluten/casein assumption. The prevalence antibodies to gliadin and milk proteins in children with paired/impaired intestinal permeability under dietary regimen either regular or restricted is reported. Methods 162 ASDs 44 healthy were investigated for permeability, tissue-transglutaminase (tTG), anti-endomysium (EMA)-IgA, total mucosal IgA exclude celiac disease; HLA-DQ2/-DQ8 haplotypes; systemic (IgA, IgG,...
The uremic toxin p ‐cresol (4‐methylphenol) is either of environmental origin or can be synthetized from tyrosine by cresol‐producing bacteria present in the gut lumen. Elevated amounts have been previously found urines Italian and French autism spectrum disorder (ASD) children up until 8 years age, may associated with severity intensity abnormal behaviors. This study aims to investigate mechanism producing elevated urinary ASD. Urinary levels were thus measured High Performance Liquid...
AIM:To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis irritable bowel disease (IBS) in our geographical area, and to collect information on use locally acting non-absorbable antibiotics management SIBO. METHODS:A non-interventional study was conducted 73 consecutive a symptom-based diagnosis. RESULTS:When underwent "breath test", 33 (45.2%) showed presence SIBO.After treatment rifaximin 1200 mg/d for seven days 32 patients, 19...
The effect of bombesin on insulin, pancreatic glucagon, and gut glucagon was investigated in eight healthy volunteers two pancreatectomized patients. Bombesin, infused iv at the constant rate 5 ng kg−1 min−1, produced a sharp statistically significant rise plasma insulin concentration. peak reached min (26 ± 2.17 μU/ml; P < 0.005 vs. basal values), followed by prolonged (P 0.05) decrease blood glucose. Pancreatic rapidly rose to maximal value 80.5 7.6 pmol/liter values). In contrast with...
5-Fluorouracil (5-FU), in association with leucovorin (LV), is the most used chemotherapy agent treatment of colorectal cancer. Response rate, as well side-effect incidence, increases dose intensity regimens that are used. The common dose-limiting toxicity for 5-FU/LV modulation diarrhea. To assess modification small intestinal function, we investigated changes permeability (IP) and absorption (IA) 41 chemo-naive patients (21 men 22 women; mean age, 61 +/- 9 years) advanced cancer after...