A5078306032- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Mast cells and histamine
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Celiac Disease Research and Management
- Food Allergy and Anaphylaxis Research
- Immunotherapy and Immune Responses
- Signaling Pathways in Disease
- IL-33, ST2, and ILC Pathways
- Urticaria and Related Conditions
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Microscopic Colitis
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
Exosome Diagnostics (United States)
2024
University of Salerno
2013-2023
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2023
Johns Hopkins University
2004-2020
Johns Hopkins Medicine
1997-2020
Institute for Experimental Endocrinology and Oncology
2019
National Research Council
2019
Massachusetts General Hospital
2015
University of Baltimore
2010-2013
University of Maryland, Baltimore
2010-2011
Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten. Gluten-sensitive individuals (GS) cannot tolerate gluten and may develop gastrointestinal symptoms similar to those in CD, but overall clinical picture generally less severe not accompanied concurrence tissue transglutaminase autoantibodies or comorbidities. By studying comparing mucosal expression genes associated with intestinal barrier function, as well innate adaptive immunity CD compared GS, we sought...
Cytomegalovirus (CMV), a prevalent pathogen, causes severe disease in immunocompromised humans. However, present understanding is limited regarding the long-term clinical effect of persistent CMV infection immunocompetent adults. The authors conducted prospective observational cohort study (1992–2002) 635 community-dwelling women Baltimore, Maryland, aged 70–79 years Women's Health and Aging Studies to examine on risk frailty, common geriatric syndrome, mortality older women. baseline serum...
Abstract Up-regulation of C-C chemokine expression characterizes allergic inflammation and atopic diseases. A functional mutation in the proximal promoter RANTES gene has been identified, which results a new consensus binding site for GATA transcription factor family. higher frequency this allele was observed individuals African descent compared with Caucasian subjects (p < 0.00001). The mutant associated dermatitis children German Multicenter Allergy Study (MAS-90; p 0.037), but not...
<i>Background:</i> The immune-mediated enteropathy, celiac disease (CD), and gluten sensitivity (GS) are two distinct clinical conditions that both triggered by the ingestion of wheat gliadin. CD, but not GS, is associated with possibly mediated an autoimmune process. Recent studies show gliadin may induce activation IL-17-producing T cells IL-17 expression in CD mucosa correlates intake. <i>Methods:</i> small-intestinal patients GS dyspeptic controls was analyzed for...
Chronic inhalation of cigarette smoke is a prominent cause chronic obstructive pulmonary disease (COPD) and provides an important source exogenous oxidants. In addition, several inflammatory structural cells are endogenous oxidants in the lower airways COPD patients, even former smokers. This suggests that play key role pathogenesis COPD. oxidative stress counterbalanced by protective effects various antioxidant defenses airways. A large amount data from animal models patients with have...
Abstract The C-C chemokine eotaxin is a potent chemoattractant for eosinophils and probably plays an important role in the pathogenesis of asthma, although mechanisms its regulation are not well known. Airway epithelial cells express mRNA protein after stimulation with variety cytokines. We focused on molecular gene by TNF-α IL-4 airway cell line, BEAS-2B. Cells were transfected luciferase reporter plasmids, which contained up to 1363 bp promoter. Eotaxin promoter activity was increased...
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Abstract Atopy, which predisposes individuals to develop asthma, severe systemic anaphylaxis, and atopic dermatitis, is usually associated with dramatically elevated total serum IgE levels thought be controlled by a major susceptibility gene multiple minor genes. A recent sib-pair analysis revealed tight linkage between markers on 5q31.1 controlling levels. Due its location within this cluster biologic role in Ig class switching Th2 cell differentiation, the IL-4 has emerged as one candidate...
The autoimmune enteropathy, coeliac disease (CD), is triggered by ingestion of gluten-containing grains. We recently reported that the chemokine receptor CXCR3 serves as a for specific gliadin peptides cause zonulin release and subsequent increase in intestinal permeability. To explore role immune response to gliadin, peripheral blood mononuclear cells from both patients with CD healthy controls were incubated either pepsin-trypsin-digested or 11 α-gliadin synthetic presence absence blocking...
Mutual interactions between cancer cells and the tumor microenvironment importantly contribute to development of tyrosin kinase inhibitor (TKI) resistance in patients affected by EGFR-mutant NSCLC. In particular, immune recognition-associated proteins with impact on cell clearance through phagocytosis, such as CD47 calreticulin, could adaptive immune-escape. Preclinical studies targeting anti-phagocytic molecule showed promising results different types including lung cancer, but no data are...
Antimicrobial resistance represents one of the main threats to healthy ecosystems. In recent years, among multidrug-resistant microorganisms responsible for nosocomial infections, Enterococcus species have received much attention. Indeed, peculiar skills in their ability acquire genes and cause severe diseases, such as endocarditis. This study showed prevalence antimicrobial rate spp. isolated from clinical samples, January 2015 December 2019 at University Hospital "San Giovanni di Dio e...
Abstract During inflammatory responses, a major posttranscriptional regulation of early response and gene expression occurs through modulation mRNA turnover. We report that two potent inducers the CC chemokine eotaxin, TNF-α IL-4, regulate its production in airway epithelial cells by increasing eotaxin stability. In experiments using transcriptional inhibitor actinomycin D, half-life was significantly prolonged cell stimulation with or combination cytokines being most effective extending...