A5020317758- Esophageal Cancer Research and Treatment
- BRCA gene mutations in cancer
- Gastric Cancer Management and Outcomes
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- Ethics in Clinical Research
- Cancer Genomics and Diagnostics
- Cancer Risks and Factors
- Helicobacter pylori-related gastroenterology studies
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Esophageal and GI Pathology
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Cardiovascular Health and Risk Factors
- Patient Dignity and Privacy
- Global Cancer Incidence and Screening
- Ferroptosis and cancer prognosis
- Health Literacy and Information Accessibility
- Social Media in Health Education
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Eosinophilic Disorders and Syndromes
- Metabolism, Diabetes, and Cancer
Trinity College Dublin
2014-2024
St. James's Hospital
2012-2024
Mater Misericordiae University Hospital
2014
University College Dublin
2014
Royal College of Surgeons in Ireland
2010
Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within HLA region) and 16q23, where closest protein-coding gene is FOXF1. Subsequently, Esophageal Adenocarcinoma Consortium (BEACON) identified loci for near CRTC1 BARX1, within 100 kb FOXP1. aimed identify further SNPs that increased validate previously reported associations.
Abstract Background Epidemiological studies have linked obesity with many cancers. The insulin-like growth factor (IGF) 1 axis may be an important mediator in obesity-associated cancer. This study examined the relationship between IGF-1 and its receptor (IGF-1R) oesophageal adenocarcinoma, a cancer strongly to obesity. Methods Patients adenocarcinoma considered suitable for attempted curative treatment were studied. Visceral adiposity was defined by waist circumference or visceral fat area....
Abstract Overweight and obesity is linked to increased incidence mortality of many cancer types. Of all cancers, oesophageal adenocarcinoma (OAC) displays one the strongest epidemiological links with obesity, accounting for up 40% cases, but molecular pathways driving this association remain largely unknown. This study aimed elucidate mechanisms underpinning cancer, determine if visceral associated aggressive tumour biology in OAC. Following co‐culture adipose tissue explants, expression...
Effective therapeutic approaches are urgently required to tackle the alarmingly poor survival outcomes in esophageal adenocarcinoma (EAC) patients. EAC originates from within intestinal-type metaplasia, Barrett's esophagus, a condition arising on background of gastroesophageal reflux disease and associated inflammation.This study used druggable genome small interfering RNA (siRNA) screening library 6022 siRNAs conjunction with bioinformatics platforms, genomic studies tissues, somatic...
Abstract Background Irish Health Research Regulations (HRRs) were introduced following the commencement of General Data Protection Regulation (GDPR) in 2018. The HRRs set out supplementary regulatory requirements for research. A legal analysis presented under auspices Academy Medical Sciences (IAMS) on April 8 and November 25, 2019 at Royal College Surgeons Ireland welcomed introduction GDPR HRRs. found “explicit consent” by is problematic. call was made to regulate informed consent line...
Abstract Barrett’s oesophagus (BO), an intestinal-type metaplasia (IM), typically arising in conjunction with gastro-oesophageal reflux disease, is a prominent risk factor for the development of oesophageal adenocarcinoma (OAC). The molecular similarities between IM and normal intestinal tissues are ill-defined. Consequently, contribution intestine-enriched factors expressed within BO to oncogenesis unclear. Herein, using transcriptomics we define genes meta-profiles OAC. Interestingly, 77%...
OBJECTIVES: Obesity is linked to increased mortality from many cancer types, and esophageal adenocarcinoma (EAC) displays one of the strongest epidemiological associations. The aims this study are dissect molecular pathways linking obesity with EAC determine if aggressiveness disease. METHODS: Affymetrix microarrays identified altered signaling in an cell line following coculture visceral adipose tissue or isolated adipocytes viscerally obese patients (n=6). Differentially expressed genes...
Breast cancer is the most common female worldwide. The lifetime risk of a woman being diagnosed with breast approximately 12.5%. For women who carry deleterious mutation in either BRCA genes, BRCA1 or BRCA2, developing ovarian significantly increased. In recent years there has been increased penetrance and BRCA2 associated cancer, prompting investigation into role modifiable factors this group. Previous investigations topic have relied on participants recalling weight changes subjective...
Barrett's esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While is a leading known risk factor for esophageal adenocarcinoma, pathogenesis this disease sequence poorly understood. Mitochondria are highly susceptible to mutations due high levels reactive oxygen species (ROS) coupled with low DNA repair. The timing and mitochondria instability dysfunction across under studied.Using an in-vitro model representing normal squamous epithelium (HET1A),...
Abstract Purpose The association between pathological complete response (pCR) in patients receiving neoadjuvant chemotherapy (NAC) for breast cancer and Circulating Tumour Cells (CTCs) is not clear. aim of this study was to assess whether CTC enumeration could be used predict NAC as measured by the Miller–Payne grading system. Methods Twenty-six were recruited, blood samples taken pre- post-NAC. CTCs isolated using ScreenCell device stained a modified Giemsa stain. enumerated 2 pathologists...
Abstract Background Irish Health Research Regulations (HRRs) were introduced following the European Union (EU) General Data Protection Regulation (GDPR) in 2018. The HRRs described specific supplementary regulatory requirements for research regarding governance, processes and procedure that impact on several facets of research. numerous problems particularly “explicit consent” inadvertently created presented under auspices Academy Medical Sciences (IAMS) November 25, 2019, at Royal College...
Elevated levels of plasma homocysteine (Hcy) are an independent risk factor for cardiovascular disease and thrombosis. The molecular basis this phenomenon is not known but may relate to modification cell surface thiols. platelet specific integrin αIIbβ3 a cysteine-rich adhesion molecule that plays critical role in aggregation haemostasis In study, we looked evidence homocysteine-induced using fluorescently labeled PAC-1 antibody recognizes the activated conformation on surface. We show...
Background: The Savi Scout® radar system is a novel approach for localizing non-palpable breast lesions. aim of this pilot study was to compare traditional wire guided localisation (WGL) and (SSL) lesions in women undergoing conserving surgery.
Abstract Introduction: Obesity is an independent risk-factor for oesophageal adenocarcinoma. Adipose tissue endocrine organ secreting numerous factors with different biological activities. We aimed to investigate the molecular mechanisms linking obesity and cancer in cancer. Methods: conditioned media (ACM) was prepared from omental adipose of adenocarcinoma patients. Proliferation cells(OE33, OE19) response ACM examined by BrdU. OE33 cell line co-culture visceral gene expression pathways...
Abstract Background: Detection and enumeration of Circulating Tumour Cells (CTCs) has been evaluated in many cancers such as breast cancer. However, the full prognostic predictive power CTCs for cancer cannot currently be harnessed, association between pathological complete response patients receiving neoadjuvant chemotherapy is still not clear. The aim this study was to assess if could used predict patients. Methods: 26 were recruited, blood samples taken pre- post-neoadjuvant chemotherapy....