A5070495189- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Photodynamic Therapy Research Studies
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Porphyrin and Phthalocyanine Chemistry
- Frailty in Older Adults
- Lung Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Gastroesophageal reflux and treatments
- Bariatric Surgery and Outcomes
- Lung Cancer Treatments and Mutations
- COVID-19 and healthcare impacts
- Palliative Care and End-of-Life Issues
- Helicobacter pylori-related gastroenterology studies
Trinity College Dublin
2012-2025
St. James's Hospital
2012-2025
University College Dublin
2025
University of Coimbra
2019-2024
Royal London Hospital
2024
University College London
2024
Cancer Institute (WIA)
2022-2024
Royal National Orthopaedic Hospital NHS Trust
2024
Afe Babalola University
2022
Oregon Health & Science University
2018
Background: The FLOT protocol and the CROSS trimodality regimen represent current standards in management of locally advanced esophageal adenocarcinoma. In absence published Randomised Controlled Trial data, this propensity-matched comparison evaluated tolerance, toxicity, impact on sarcopenia pulmonary physiology, operative complications, oncologic metrics. Methods: Two hundred twenty-two patients, 111 each arm, were included from 2 high-volume centers. Computed tomography-measured...
Abstract Background Many gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months using standard chemotherapy. Innovative treatments, like targeted therapy or immunotherapy, have recently proved to ameliorate prognosis, but general agreement on managing oligometastatic disease has yet be achieved. An international multi-disciplinary workshop was held Bertinoro, Italy, November 2022 verify whether achieving consensus at...
Photodynamic therapy (PDT) is an anticancer with proven efficacy; however, its application often limited by prolonged skin photosensitivity and solubility issues associated the phototherapeutic agents. Injectable hydrogels which can effectively provide intratumoral delivery of photosensitizers sustained release are attracting increased interest for photodynamic cancer therapies. However, most PDT applications based on systems high complexity, often, preclinical validation not provided....
Abstract Background To effectively embed exercise rehabilitation in cancer survivorship care, a co-ordinated system of acute and community services, forming stepped model is recommended. Patients can be directed to the service which best meets their needs through assessment, triage referral. Triage referral systems are not yet widely applied practice need evaluated real-world contexts. The PERCS (Personalised Exercise Rehabilitation Cancer Survivorship) study aims evaluate application an...
Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of on T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study investigated profiles and if immune checkpoint blockade (ICB) could enhance immunity under acidosis. Acidic conditions substantially altered expression OAC patient-derived cells, upregulating TIM-3, LAG-3 CTLA-4. Severe (pH 5.5) significantly decreased percentage central memory CD4+ an that was...
The curative treatment for esophageal cancer (EC) is esophagectomy, a procedure which modifies the capacity to normally metabolize food. Post-esophagectomy, individuals may struggle with food intake, malabsorption, weight loss, and gastrointestinal issues, negatively impacting their quality of life (QOL). Despite increasing survival rate EC patients, little still known about dietary intake pattern over course long-term survivorship. This study aims explore nutritional survivors, comparing it...
The intrinsic challenge of large molecules to cross the cell membrane and reach intracellular targets is a major obstacle for development new medicines. We report how rotation along single C–C bond, between atropisomers drug in clinical trials, improves uptake therapeutic efficacy. redaporfin (a fluorinated sulfonamide bacteriochlorin photosensitizer 1135 Da) are separable display orders magnitude differences photodynamic efficacy that directly related their differential cellular uptake....
Abstract Background People who interact with healthcare services have an ethical and legal right to control their own lives, make informed decisions, consent what happens them. For be considered ethically legally valid, three key criteria must met: given voluntarily; people sufficiently of all options; should capacity the decision give or withhold consent. Aim This study set out explore, through use surveys, perspectives patients public in relation Method Surveys were developed for...
Introduction The growing number of people living with, through and beyond cancer poses a new challenge for sustainable survivorship care solutions. Digital health solutions which incorporate various information communication technologies are reshaping healthcare; offering huge potential to facilitate promotion, support healthcare efficiencies, improve access positively impact outcomes. include websites mobile applications, technologies, telehealth solutions, wearable devices, AI-supported...
This Delphi exercise aimed to gather consensus surrounding risk factors, diagnosis, and management of chyle leaks after esophagectomy develop recommendations for clinical practice.Chyle following malignancy are uncommon. Although they associated with increased morbidity mortality, diagnosis these patients remain controversial a challenge globally.This was modified delivered clinicians across the oesophagogastric anastomosis collaborative. A 5-staged iterative process used on practice,...
Abstract The time dependence of atropisomer interconversion has limited the pursuit single drug candidates, even in circumstances where one presents favorable biological activity over another. Moderate energy barriers risk compromising stability. As a result, examples atropisomerically pure drugs current clinical use are rare. However, recent years, there been shift towards development single, stable candidates with enhanced activity. Consequently, methods which effectively restrict rotation...
Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current treatment modalities and has strong link obesity. To better elucidate the role of visceral adiposity in this disease state, full metabolic profile combined analysis secreted pro-inflammatory cytokines, metabolites, lipid profiles were assessed human ex vivo adipose tissue explants from obese non-obese OAC patients. These data then related extensive clinical including obesity status,...
The COVID-19 pandemic has significantly impacted the traditional delivery of medical education. Medical education programmes have had to cope with limitations on face-to-face learning, and accelerate adoption digital learning. In addition, potential serious implications psychological well-being students. We aim assess changes in perceptions experiences students as a consequence this pandemic.Cross-sectional survey at Trinity College Dublin (TCD) between March April 2022 was performed....
Abstract The ECCG developed a standardized platform for reporting operative complications, with consensus definitions, and DUCA adopted these definitions have reported comparison against benchmarks. aim of this study was to report five year complications data using the Esophageal Complications Consensus Group (ECCG), compare published benchmark studies from collaborative group Dutch Upper Gastrointestinal Cancer Audit (DUCA). Methods All patients undergoing multimodal therapy or surgery...
Visceral obesity (VO) and metabolic syndrome (MetS) are risk factors for esophageal adenocarcinoma (EAC); however, their impact on operative oncological outcomes is unclear. The aim of this study was to determine the incidence VO MetS among patients with EAC, assess independent outcomes. A total 454 consecutive undergoing treatment curative intent were studied. Total, subcutaneous, visceral fat area (VFA), lean body mass (LBM) measured by computed tomography pretreatment, defined as VFA...
In the contemporary era of cancer immunotherapy, an abundance clinical and translational studies have reported radiotherapy (RT) immunotherapies as a viable option for immunomodulation many subtypes, with related trials ongoing. locally advanced disease, chemotherapy or chemoradiotherapy followed by surgical excision tumour remain principal treatment strategy in oesophageal adenocarcinoma (OAC), however, use host immune system to improve anti-tumour immunity is rapidly garnering increased...
Use of immune checkpoint blockade to enhance T cell-mediated immunity within the hostile tumour microenvironment (TME) is an attractive approach in oesophageal adenocarcinoma (OAC). This study explored effects TME, including nutrient deprivation and hypoxia, on (IC) expression cell phenotypes, potential use nivolumab function under such conditions.ICs were upregulated stromal cells PD-L2, CTLA-4 TIGIT. OAC patient-derived PBMCs co-cultured with OE33 LAG-3 downregulated co-stimulatory marker...