A5002099859- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Hip and Femur Fractures
- Anesthesia and Pain Management
- Pelvic and Acetabular Injuries
- COVID-19 and healthcare impacts
- Cancer, Stress, Anesthesia, and Immune Response
- Colorectal Cancer Surgical Treatments
- Clinical practice guidelines implementation
- Reconstructive Surgery and Microvascular Techniques
- Autoimmune Bullous Skin Diseases
- Gastroesophageal reflux and treatments
- Cancer Cells and Metastasis
- Anatomy and Medical Technology
- Hernia repair and management
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Minimally Invasive Surgical Techniques
- Autoimmune and Inflammatory Disorders
- Food Allergy and Anaphylaxis Research
- Global Healthcare and Medical Tourism
- Angiogenesis and VEGF in Cancer
- Venous Thromboembolism Diagnosis and Management
- Social Media in Health Education
Trinity College Dublin
2015-2025
Royal College of Surgeons in Ireland
2021-2025
University College Dublin
2025
St. James's Hospital
2021-2023
Midland Regional Hospital Mullingar
2021
Summary Optimal pain control following esophagectomy remains a topic of contention. The aim was to perform systematic review and network meta-analysis (NMA) randomized clinical trials (RCTs) evaluating the analgesia strategies post-esophagectomy. A NMA performed according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA)-NMA guidelines. Statistical analysis using Shiny R. Fourteen RCTs which included 565 patients assessed nine techniques were included. Relative systemic...
Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current treatment modalities and has strong link obesity. To better elucidate the role of visceral adiposity in this disease state, full metabolic profile combined analysis secreted pro-inflammatory cytokines, metabolites, lipid profiles were assessed human ex vivo adipose tissue explants from obese non-obese OAC patients. These data then related extensive clinical including obesity status,...
Background Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains unknown. Our study profiles systemic anti-tumor immunity perioperatively help inform optimal timing into current standards care EAC patients. Methods Systemic 11 patients was phenotyped immediately prior esophagectomy (POD-0) and post-operatively (POD)-1, 3, 7 week 6. Longitudinal...
This timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost in perioperative window upper gastrointestinal cancer (UGI) patients.PBMCs were isolated from 11 UGI patients undergoing tumour resection post-operative days (POD) 0, 1, 7 42 expanded ex vivo using anti-CD3/28 IL-2 for 5 absence/presence nivolumab or ipilimumab. T cells subsequently immunophenotyped via flow cytometry to determine...
Childhood food allergy (FA) prevalence continues to increase. Skilled primary care involvement is essential for effective management. The study sought obtain feedback from GPs in Ireland regarding their approach paediatric FA, and access training expert advice. An online questionnaire was composed distributed GPs, recruited through a database, across the Republic of Ireland. A quota 100 complete responses set. All analyses were performed on SPSS MS Excel statistical software. 66% report that...
Educational podcast series are becoming increasingly popular as free open access medical education (FOAMed) resources, however, the educational benefit associated with their use is unclear. The aim of this study was to assess outcomes implementation a surgical for undergraduate students.
Background: Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of oesophageal cancer. The most appropriate time to incorporate ICIs remains unknown. Our study profiles systemic anti-tumour immunity perioperatively help inform optimal timing into current standards care adenocarcinoma (OAC) patients.Methods: Systemic was immunophenotyped pre- and post-oesophagectomy on days 0, 1, 3, 7 week 6 by flow cytometry (n=14). frequency...
Background: The unprecedented burden of the COVID pandemic has brought with it many challenges including economic, social, infrastructural, and crucially significant disruptions in healthcare provision. Consequently, certain aspects elective care have been deprioritised to enable health systems respond resulting growing waiting lists, delayed some cases suboptimal care. purpose current study is evaluate impact on scheduled nationally.Methods: Data was sourced from National Quality Assurance...
Background: Traditionally, oesophageal oncological resections have been performed via open approaches with well-documented levels of morbidity and mortality complicating the post-operative course. Recently, minimally invasive garnered sustained support in all areas surgery, there has an exponential adaptation this technology upper GI surgery advent laparoscopic techniques and, more recently, robotic surgery. The current literature while growing, is inconsistent reporting on benefits...
<h3>Background</h3> Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of oesophageal adenocarcinoma (OAC). The most appropriate time to incorporate ICIs remains unknown. Our study profiles systemic anti-tumour immunity perioperatively help inform optimal timing into current standards care OAC patients. <h3>Methods</h3> Systemic 11 patients was phenotyped prior oesophagectomy and on post-operative days (POD) 0, 1, 3, 7 week 6...
Abstract Background While the use of robotic-assisted surgery is now mainstream for procedures such as robotic prostatectomy, its role in general less well established. Access to training robotics trainees Republic Ireland variable. Further, there no data on attitudes Irish towards robotics. We aimed establish perceived utility access and satisfaction with training. Methods A survey was disseminated enrolled a General Surgery scheme via email social media. Data collected included stage...
Abstract Introduction The COVID-19 pandemic has interfered with many aspects of cancer management, including delayed diagnoses, stalled screening programmes, limiting treatment and clinical trials. Colorectal is the second commonest cause death in Ireland. objective current study to assess impact this on colorectal diagnoses surgery, at a national level. Methods Data endoscopy, emergency elective operations nationally Ireland over three year period (2018-2020) were obtained from National...
Abstract Background Robotic-assisted minimally invasive surgery (MIS) for rectal cancer is a relatively new technique. Studies to date suggest that short term outcomes including TME quality, margin status, lymph node retrieval and 30-day morbidity mortality are equivalent in robotic-assisted laparoscopic MIS cancer. By contrast, there paucity of data on the medium long-term oncologic safety comparative Methods A retrospective review was conducted all (n = 31) 23) cases performed at our...