A5066974810- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Bone health and osteoporosis research
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Collagen: Extraction and Characterization
- Silk-based biomaterials and applications
- Bone fractures and treatments
- Knee injuries and reconstruction techniques
- Bone health and treatments
- Orthopedic Infections and Treatments
- Nerve injury and regeneration
- Cellular Mechanics and Interactions
- Pelvic floor disorders treatments
- Graphene and Nanomaterials Applications
- Connective tissue disorders research
- Kidney Stones and Urolithiasis Treatments
- MicroRNA in disease regulation
Royal College of Surgeons in Ireland
2016-2025
Trinity College Dublin
2016-2025
Advanced Materials and BioEngineering Research
2016-2025
University of Medicine and Health Sciences
2025
University College Dublin
2025
Science Foundation Ireland
2022-2024
Guangdong Institute of New Materials
2023
Ollscoil na Gaillimhe – University of Galway
2018-2023
University Hospital Galway
2023
Medical University of Graz
2023
Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease trauma. The developing field engineering (TE) aims regenerate tissues by combining cells from the body with highly porous scaffold biomaterials, which act as templates for regeneration, guide growth new tissue. This article describes functional requirements, and types, materials used in state art scaffolds applications. Furthermore, it challenges where future research...
Mean pore size is an essential aspect of scaffolds for tissue-engineering. If pores are too small cells cannot migrate in towards the center construct limiting diffusion nutrients and removal waste products. Conversely, if large there a decrease specific surface area available cell attachment. However relationship between scaffold activity poorly understood as result conflicting reports within literature on optimal required successful Previous studies bone tissue-engineering have indicated...
The permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion nutrients in waste out scaffold well influencing pressure fields within construct. objective this study was to characterize permeability/fluid mobility collagen-GAG a function pore size compressive strain using both experimental mathematical modeling techniques. Scaffolds containing four distinct mean sizes (151, 121, 110, 96 microns) were...
Crosslinking and the resultant changes in mechanical properties have been shown to influence cellular activity within collagen biomaterials. With this mind, we sought determine effects of crosslinking on both compressive modulus collagen-glycosaminoglycan scaffolds osteoblasts seeded them. Dehydrothermal, 1-ethyl-3-3-dimethyl aminopropyl carbodiimide glutaraldehyde treatments were first investigated for their effect scaffolds. After this, most promising used study attachment, proliferation,...
There is an enduring and unmet need for a bioactive, loadbearing tissue-engineering scaffold, which biocompatible, biodegradable capable of facilitating promoting osteogenesis when implanted in vivo.This study set out to develop biomimetic scaffold by incorporating osteoinductive hydroxyapatite (HA) particles into highly porous extremely biocompatible collagenbased developed within our laboratory over the last number years improve osteogenic performance.Specifically we investigated how...
Recent investigations into micro-architecture of scaffolds has revealed that mean pore sizes are cell-type specific and influence cellular shape, differentiation, extracellular matrix secretion. In this context, the overall goal study was to investigate whether scaffold affect mesenchymal stem cell initial attachment, chondrogenic gene expression, cartilage-like deposition. Collagen-hyaluronic acid (CHyA) scaffolds, recently developed in our laboratory for vitro chondrogenesis, were...
The extent of regeneration following biomaterial implantation is dependent on the microenvironment surrounding implant. Since implant composition can have a profound effect inflammation, it essential to understand this process as non-resolving inflammatory response lead fibrous encapsulation and insufficient integration. Incorporation particulates into implants confers structural functional benefits, thus optimizing particulate characteristics enhance immune mediated efficacy important. We...
Much research is currently ongoing into new therapies for cartilage defect repair with biomaterials frequently appearing which purport to have significant regenerative capacity. These may be classified as medical devices, and such must undergo rigorous testing before they are implanted in humans. A large part of this involves vitro trials biomechanical testing. However, order bridge the gap between lab clinic, vivo preclinical required, usually demanded by regulatory approval bodies. This...
Abstract Functional conductive hydrogels are widely used in various application scenarios, such as artificial skin, cell scaffolds, and implantable bioelectronics. However, their novel designs technological innovations severely hampered by traditional manufacturing approaches. Direct ink writing (DIW) is considered a viable industrial‐production 3D‐printing technology for the custom production of according to intended applications. Unfortunately, creating functional DIW has long been plagued...
Chronic wounds remain in a state of disrupted healing, impeding neurite outgrowth from injured nerves and poor development new blood vessels by angiogenesis. Current therapeutic approaches primarily focus on...
The mechanical properties of tissue engineering scaffolds are critical for preserving the structural integrity and functionality during both in vivo implantation long-term performance. In addition, scaffold can direct cellular activity within a tissue-engineered construct. this context, aim study was to investigate effects dehydrothermal (DHT) treatment on collagen-glycosaminoglycan (CG) scaffolds. Temperature (105-180 degrees C) exposure period (24-120 h) DHT were varied determine their...