Chronic wounds remain in a state of disrupted healing, impeding neurite outgrowth from injured nerves and poor development new blood vessels by angiogenesis. Current therapeutic approaches primarily focus on...

The influence of sociodemographic, clinical and treatment factors on the quality life patients with schizophrenia has yet to be fully defined. We evaluated who were attending a catchment area rehabilitation centre, in order establish its correlates. These had poor moderate which was inversely related negative symptom severity, illness duration, cumulative length previous hospitalization patient age. Patients residing hostels or group homes poorer than those living independently their family....

To map the development of insight in 4 years after presentation with first-episode schizophrenia and schizophreniform disorder to determine effects evolving on depression likelihood attempted suicide.We assessed 101 individuals at presentation, 6 months years. We measured insight, including recognition mental illness, need for treatment ability relabel psychotic symptoms. recorded all suicide attempts.Insight improved time. Recognition illness predicted years.Six greater acknowledgement by...

Extracellular matrix (ECM)-based scaffolds, through their inherent bioactivity and molecular recognition signals, provide the ideal substrate for tissue engineering regenerative applications. Collagen, most abundant ECM protein, has proven itself to be a very versatile material with applications in many fields, including leather food industries, cosmetics, drug delivery, engineering. However, doubts persist about optimal source of collagen applications, given possible immunogenicity disease...

Directing appropriate extracellular matrix remodeling is a key aim of regenerative medicine strategies. Thus, antifibrotic interfering RNA (RNAi) therapy with exogenous microRNA (miR)-29B was proposed as method to modulate following cutaneous injury. It hypothesized that delivery miR-29B from collagen scaffold will efficiently the response and reduce maladaptive such aggressive deposition type I after The release assessed its ability silence III expression evaluated in vitro. When primary...

Chronic, nonhealing wounds in the form of diabetic foot ulcers (DFUs) are a major complication for patients. The inability DFU to heal appropriately leads an open wound with high risk infection. Current standards care fail fully address either underlying defective repair mechanism or microbial Thus, it is clear that novel approaches needed. One such approach use multifunctional biomaterials as platforms direct and promote healing. In this study, biomimetic, bilayered antimicrobial...

Abstract The aim of this study was to identify the features first episode schizophrenia that predict adherence antipsychotic medication at six-month follow-up. We used validated instruments assess clinical and socio-demographic variables in all patients with from a defined geographical area admitted Dublin psychiatric hospital over four-year period ( N = 100). At follow-up 60) we assessed using Compliance Interview. One third were non-adherent within six months their illness. High levels...

Volumetric muscle loss (VML) injuries are characterized by a degree of tissue that exceeds the endogenous regenerative capacity muscle, resulting in permanent structural and functional deficits. Such consequence trauma, as well host congenital acquired diseases disorders. Despite significant preclinical research with diverse biomaterials, early clinical studies implantation decellularized extracellular matrices, there still barriers to more complete restoration form function following repair...

Background. Although it is well recognized that individuals with schizophrenia display evidence of subtle neurological impairment, its aetiopathological and clinical significance continues to be unclear. Methods. Patients presenting a first episode or schizophreniform psychosis (DSM-IV criteria) were examined using two previously validated examinations. The majority ( N = 35) prior their ‘first ever’ dose neuroleptic while the remaining patients 21) had been medicated for less than one...

Objective: To estimate the prevalence, and identify clinical correlates of comorbid substance misuse (abuse or dependence) among readmissions with schizophrenia, particularly to establish whether is associated higher rates depressive symptoms suicidal ideation. Method: Over 12 months, consecutive from a catchment area psychiatric service DSM‐IV schizophrenia/schizoaffective disorder were assessed using assessments symptomatology including depression, insight compliance. Comorbid was...

This study assessed the manner in which insight influenced schizophrenic patients' evaluation of their objective life conditions and concurrent validity between clinicians' assessments global quality life.Forty out-patients who fulfilled DSM-III-R criteria for schizophrenia were independently interviewed using Lancashire Quality Life Profile Standard Living Interview. Insight was a self-report questionnaire, Scale.For insightful patients there significant but modest correlation subjective...

Having a diagnosis of schizophrenia is risk factor for involuntary admission to psychiatric inpatient care, but we have limited understanding why some patients and not others require admission. We aimed identify the predictors in first episode schizophrenia. used validated instruments assess clinical socio-demographic variables all (n = 78) with from defined geographical area admitted Dublin hospital over 4-year period. Involuntary 17) could be distinguished voluntary 61) on basis age,...

Current treatment options for craniofacial volumetric muscle loss (VML) have disadvantages and cannot fully restore normal function. Bio-inspired semisynthetic acrylated hyaluronic acid (AcHyA) hydrogel, which fills irregularly shaped defects, resembles an extracellular matrix, induces a minimal inflammatory response, has shown promise in experimental studies of extremity VML. We therefore sought to study AcHyA hydrogel the For this, we used novel model masseter VML rat. Following creation 5...

Background. Although patients with schizophrenia have increased rates of neurological soft signs, few studies examined prospectively their trait or state characteristics in relation to psychopathology. Method. In a prospective study 97 first-episode (DSM-IV criteria) we assessed signs and psychopathology at presentation 6 month follow-up for 73 cases. To establish whether were associated variations clinical state, measured using two validated examinations (Neurological Evaluation Scale...

Functionalisation of biomaterials with therapeutic moieties (proteins, drugs, genes) is a pre-requisite to tissue regeneration and restoration function following injury or disease.

Abstract Extracellular matrix synthesis and remodelling are driven by increased activity of transforming growth factor beta 1 (TGF-β1). In tendon tissue repair, TGF-β1 leads to progressive fibrosis. Decorin (DCN) interleukin 10 (IL-10) antagonise pathological collagen exerting a neutralising effect via downregulation TGF-β1. Herein, we report that the delivery DCN IL-10 transgenes from hydrogel system supresses constitutive expression range pro-fibrotic extracellular genes.

Cell-based strategies for the treatment of ischemic diseases are at forefront tissue engineering and regenerative medicine. Cell therapies purportedly can play a key role in neovascularization tissue; however, low survival poor cell engraftment with host vasculature following implantation limits their potential to treat diseases. To overcome these limitations, we previously developed growth factor sequestering hyaluronic acid (HyA)-based hydrogel that enhanced transplanted mouse...