A5021901487- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Hydrogels: synthesis, properties, applications
- Oral microbiology and periodontitis research
- Cancer Cells and Metastasis
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Mesenchymal stem cell research
- Peripheral Artery Disease Management
- Urinary and Genital Oncology Studies
- Cardiac Structural Anomalies and Repair
- Polymer Surface Interaction Studies
- Smoking Behavior and Cessation
- Advanced Sensor and Energy Harvesting Materials
- School Health and Nursing Education
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
Royal College of Surgeons in Ireland
2014-2024
St Bernard's Hospital
2016
National Children’s Research Centre
2009
Our Lady's Hospital
2004-2009
University College Dublin
2004
Children's Health Ireland at Crumlin
2004
Trinity College Dublin
2004
Newcastle University
1999
Royal Victoria Infirmary
1999
Novel block copolymers comprising poly(ethylene glycol) (PEG) and an oligo(tyrosine) were synthesized in different compositions by N-carboxyanhydride (NCA) polymerization. It was shown that PEG2000-Tyr(6) undergoes thermoresponsive hydrogelation at a low concentration range of 0.25-3.0 wt % within temperature 25-50 °C. Cryogenic transmission electron microscopy (Cryo-TEM) revealed continuous network fibers throughout the hydrogel sample, even concentrations as 0.25 %. Circular dichroism (CD)...
Cardiac stem cells (CSCs) represent a logical cell type to exploit as regenerative treatment option for tissue damage accrued result of myocardial infarction. However, the isolation and expansion CSCs prior transplantation is time consuming, costly invasive, reliability may also prove be major obstacle in clinical application CSC-based therapy after In order overcome this, we propose incorporation growth factor-eluting alginate microparticles into collagen-based scaffolds an implantable...
Background: Cardiovascular diseases (CVD) account for 36% of deaths in Europe and the United States. Gene therapy can act as a therapeutic modality treatment CVD. The use microRNA mimetics may be advantageous they regulate important
Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall restore cardiac function or deliver stem cells in regenerative therapy have shown promising data. However, clinical translation of hydrogel-based therapies has been limited due difficulties injecting them through catheters. We engineered a novel catheter, Advanced Materials Catheter (AMCath), overcomes translational hurdles associated with delivering fast-gelling covalently cross-linked hyaluronic acid...
Introduction: Drug-based treatment regimens for cancer are often associated with off-target toxic side effects and low penetration of the drug at tumor site leading to patient morbidity limited efficacy. Loco-regional delivery has potential increase efficacy while concomitantly reducing toxicity.Areas covered: Clinical applications using loco-regional include intra-arterial in retinoblastoma, direct intra-tumoral (IT) injection ethanol ablation hepatocellular carcinoma (HCC) use HIPEC...
Abstract Regenerative medicine approaches, specifically stem cell technologies, have demonstrated significant potential to treat a diverse array of pathologies. However, such approaches resulted in modest clinical benefit, which may be attributed poor retention/survival at the disease site. A delivery system that facilitates regional and repeated target tissues can provide enhanced efficacy therapies when localized high doses cells is required. In this study, new regenerative reservoir...
Macroencapsulation systems have been developed to improve islet cell transplantation but can induce a foreign body response (FBR). The development of neovascularization adjacent the device is vital for survival encapsulated islets and limitation long-term success. Previously we additive manufactured multi-scale porosity implants, which demonstrated 2.5-fold increase in tissue vascularity integration surrounding implant when compared non-textured implant. In parallel this,...
Vesicoureteral reflux familial clustering implies that genetic factors have a key role in pathogenesis. We identified genes cause this disease and elucidated the biology genetics of vesicoureteral reflux.There were 166 families 738 individuals, including 319 parents 419 offspring. The had 193 affected sib pairs whom was confirmed by voiding cystourethrogram. DNA samples obtained to analyze various candidate or regions with urinary tract development, eg UPK3, UPK2, UPK1B, Chr.10q25.3, KAL1,...
Aim: The aim of this study was to evaluate the formulation a synthetic IGF-1 (pIGF-1) in PLGA microparticles (MP). Methods: Poly (lactic-co-glycolic acid) (PLGA) MPs loaded with pIGF-1 were prepared, characterised and evaluated using double emulsion solvent evaporation method. Results: Spherical showed an average particle size 2 µm, encapsulation efficiency (EE) 67% 50% degradation over 15 days. With view enhancing retention myocardium, MP encapsulated cross-linked hyaluronic acid hydrogel....
Minimally invasive intratumoural administration of thermoresponsive hydrogels, that transition from liquid to gel in response temperature, has been proposed as a potential treatment modality for solid tumours. The aim this study was assess the inherent cytotoxicity poloxamer-based hydrogel murine xenograft model lung cancer.