A5089893159- Neuroscience and Neuropharmacology Research
- Protein purification and stability
- Monoclonal and Polyclonal Antibodies Research
- Stress Responses and Cortisol
- HER2/EGFR in Cancer Research
- Vitamin D Research Studies
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Memory and Neural Mechanisms
- HIV, Drug Use, Sexual Risk
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Cancer Cells and Metastasis
- Substance Abuse Treatment and Outcomes
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Opioid Use Disorder Treatment
- Nanoplatforms for cancer theranostics
- Antimicrobial Resistance in Staphylococcus
- Blood Pressure and Hypertension Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Bacterial biofilms and quorum sensing
- Proteins in Food Systems
Royal College of Surgeons in Ireland
2011-2021
Trinity College Dublin
2008-2009
An animal model of depression combining genetic vulnerability and early-life stress (ELS) was prepared by submitting the Flinders Sensitive Line (FSL) rats to a standard paradigm maternal separation. We analysed hippocampal synaptic transmission plasticity in vivo ionotropic receptors for glutamate FSL rats, their controls Resistant (FRL) both lines subjected ELS. A strong inhibition long-term potentiation (LTP) lower expression NR1 subunit NMDA receptor were found rats. Remarkably, ELS...
Abstract The persistent cognitive disruptive effects of stress have been strongly implicated in the pathophysiology depression and post‐traumatic disorder. Here we examined factors influencing time course recovery from inhibitory effect acute inescapable stressors on ability to induce long‐term potentiation (LTP) dorsal hippocampus vivo. We tested different forms LTP, inbred strains rats. Acute elevated platform completely, but transiently (<3 h), inhibited induction both NMDA...
A major limitation of biological therapeutics is their propensity for degradation particularly in aqueous solutions hence resulting short shelf-life. In this study, the stability trastuzumab (Herceptin®) intravenous (i.v.) solutions, an IgG1 monoclonal antibody (mAb), indicated treatment HER2 positive breast cancer, stored under refrigerated conditions, was evaluated over 28 days. No change visual appearance or average particle size observed. The pH values i.v. remained stable time....
Abstract Aims To examine the risk of mortality associated with interruptions to continuity methadone maintenance treatment (MMT), including transfers between services, in opioid‐dependent individuals attending specialist addiction services. Design Retrospective cohort study using services and primary care dispensing records, National Methadone Register Drug‐Related Death Index (NDRDI). Setting Geographically defined population Dublin, Ireland. Participants A total 2899 people prescribed...
Objective Previous prevalence estimates of POtentially Serious Alcohol–Medication INteractions in Older adults (POSAMINO) are based on in-home inventories medications; however, this method is associated with under-reporting medications when compared dispensing records. This study aims to estimate the POSAMINO among community-dwelling older using drug data from community pharmacy setting. Design Cross-sectional study. Setting Irish Community Pharmacy. Participants 1599 consecutive presenting...
The aim of the present study was to investigate influence process shear stressors on stability a model monoclonal antibody, trastuzumab. Trastuzumab, at concentrations 0.4-4.0 mg/mL, subjected sonication, freeze-thaw, lyophilisation, spray drying and encapsulated into micro- nanoparticles. stressed samples were analysed for structural integrity by gel electrophoresis, SDS-PAGE, size exclusion chromatography (SEC), while conformational circular dichroism (CD). Biological activity trastuzumab...
Minimally invasive intratumoural administration of thermoresponsive hydrogels, that transition from liquid to gel in response temperature, has been proposed as a potential treatment modality for solid tumours. The aim this study was assess the inherent cytotoxicity poloxamer-based hydrogel murine xenograft model lung cancer.
The bacterial pathogen Staphylococcus aureus is a leading cause of bloodstream infections, where patients often suffer from relapse despite antibiotic therapy. Traditional anti-staphylococcal drugs display reduced effectivity against internalised bacteria, but nanoparticles conjugated with antibiotics can overcome these challenges. In the present study, we aimed to characterise internalisation and re-emergence S. human endothelial cells construct new formulation that target intracellular...
A major limitation of biological therapeutics is their propensity for degradation particularly in aqueous solutions hence resulting short shelf-life. In this study, the stability trastuzumab (Herceptin®) intravenous (i.v.) solutions, an IgG1 monoclonal antibody (mAb), indicated treatment HER2 positive breast cancer, stored under refrigerated conditions, was evaluated over 28 days. No change visual appearance or average particle size observed. The pH values i.v. remained stable time....
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