A5042751345- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Circadian rhythm and melatonin
- Cellular transport and secretion
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Adipose Tissue and Metabolism
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Genetic Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
University of Milan
2015-2024
Sapienza University of Rome
2024
University of Milano-Bicocca
2022-2024
European University of Rome
2022
University of Trieste
2015
Cornell University
2015
Aarhus University
2015
Aarhus University Hospital
2015
North-West University
2015
Karolinska Institutet
2014
Background Behavioral stress is recognized as a main risk factor for neuropsychiatric diseases. Converging evidence suggested that acute associated with increase of excitatory transmission in certain forebrain areas. Aim this work was to investigate the mechanism whereby increases glutamate release, and if therapeutic drugs prevent effect on release. Methodology/Findings Rats were chronically treated vehicle or employed therapy mood/anxiety disorders (fluoxetine, desipramine, venlafaxine,...
Stress is a major risk factor in the onset of several neuropsychiatric disorders including anxiety and depression. Although studies have shown that social isolation stress during postweaning period induces behavioral brain molecular changes, effects on behavior adulthood been less characterized. Aim this work was to investigate relationship between alterations changes induced by chronic adult male mice. Plasma corticosterone levels adrenal glands weight were also analyzed. Socially isolated...
Glutamate neurotransmission was recently implicated in the action of stress and antidepressant mechanisms. We report that chronic (not acute) treatment with three antidepressants different primary mechanisms (fluoxetine, reboxetine, desipramine) markedly reduced depolarization-evoked release glutamate, stimulated by 15 or 25 m KCl, but not GABA. Endogenous glutamate GABA measured superfused synaptosomes, freshly prepared from hippocampus drug-treated rats. Interestingly, drugs only barely...
The hypotheses on the pathophysiology of depression/mood disorders and antidepressant mechanisms have greatly changed in recent years. classical monoamine hypothesis was revealed to be simplistic, that it could not explain temporal delay therapeutic action antidepressants. Converging lines evidence shown adaptive changes several neuroplasticity are likely cellular molecular correlates effect. In this article, analyzed relation mechanism antidepressants, ranging from gene expression...
Depression is a debilitating mental disease, characterized by persistent low mood and anhedonia. Stress represents major environmental risk factor for depression; the complex interaction of stress with genetic factors results in different individual vulnerability or resilience to disorder. Dysfunctions glutamate system have primary role depression. Clinical neuroimaging studies consistently reported alterations volume connectivity cortico-limbic areas, where neurons synapses predominate....
ABSTRACT Physical exercise and stressful experiences have been shown to exert opposite effects on behavioral functions brain plasticity, partly by involving the action of brain‐derived neurotrophic factor (BDNF). Although epigenetic modifications are known play a pivotal role in regulation different BDNF transcripts, it is poorly understood whether mechanisms also implied modulation induced physical stress. Here, we show that total mRNA levels transcripts 1, 2, 3, 4, 6, 7 were reduced...
Significance In mammals, different forms of stress, including psychosocial can affect several aspects health, fostering mood and anxiety disorders in humans. However, a lack knowledge about the mechanisms underlying brain physiology stress response hinders development new therapeutic strategies. We describe role epigenetic enzyme Lysine-Specific Demethylase 1 (LSD1) transduction pathway that translates social into an altered transcriptional plasticity genes hippocampus. particular, we show...