A5102735173- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Diabetes Management and Research
- Allergic Rhinitis and Sensitization
- Sarcoidosis and Beryllium Toxicity Research
- Air Quality and Health Impacts
- Clinical practice guidelines implementation
- Child and Adolescent Health
- Diabetes and associated disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Esophageal and GI Pathology
- Pancreatic function and diabetes
- Delphi Technique in Research
- Pharmacological Effects and Assays
- Healthcare cost, quality, practices
- Diabetes Treatment and Management
- Health Policy Implementation Science
- Occupational exposure and asthma
- Smoking Behavior and Cessation
- Indoor Air Quality and Microbial Exposure
- Ear Surgery and Otitis Media
- Diagnosis and Treatment of Venous Diseases
Newcastle upon Tyne Hospital
2004-2018
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015-2018
Freeman Hospital
2003-2017
Royal College of Physicians
2012-2017
Newcastle University
1996-2016
Nottingham City Hospital
1988-2015
British Thoracic Society
2009-2013
St. John's College
2013
St James's University Hospital
2009
Merck (Japan)
2003
Since 1999 the British Guidelines on Management of Asthma have been produced jointly by Thoracic Society (BTS) and Scottish Intercollegiate Guideline Network (SIGN) using a rigorous evidence-based methodology.Sections within guideline revised regularly, with Pharmacological section being updated nearly every year.We believe this has resulted in 'living guideline' that is responsive to new research current for clinicians.For 2011, two sections added Monitoring Control Adolescents.
Background: Patients with poorly controlled asthma have greater morbidity and mortality. This study evaluated the efficacy tolerability of omalizumab in patients controlled, moderate‐to‐severe allergic asthma. Methods: was a randomized, open‐label, multicentre, parallel‐group study. A total 312 (12–73 years) receiving ≥400 μ g/day (adolescent) or ≥800 (adult) inhaled beclomethasone dipropionate, equivalent were included. received best standard care (BSC) without [at least 0.016 mg/kg/IgE...
use of all medicines.Campaigns to inform patients about self education would be the public benefit. Good teamwork is essentialEncouraging seek advice from community pharmacist may lead a greater proportion visits doctors resulting referrals pharmacist, perhaps through formal referral forms.The change in status prescription only medicines pharmacy sale also result general practitioners referring purchase an over counter medicine.The opportunities for teamworking between two professions will...
Lower limb peripheral arterial disease (referred to as in this summary) is common, affecting 3% 7% of people the general population and 20% over age 75.1 It associated with an increased risk cardiovascular morbidity mortality severely limits people's functional capacity quality life. Peripheral often asymptomatic, but when it symptomatic most common presentation intermittent claudication (pain legs, buttocks, or thighs brought on by walking relieved rest). Critical ischaemia characterised...
Asthma exacerbations are frightening for patients and occasionally fatal. We tested the concept that a plan to manage their asthma (self-management plan), which included temporary quadrupling of dose inhaled glucocorticoids when control started deteriorate, would reduce incidence severe among adults adolescents with asthma.We conducted pragmatic, unblinded, randomized trial involving who were receiving glucocorticoids, or without add-on therapy, had at least one exacerbation in previous 12...
Community acquired pneumonia is a common condition that causes considerable morbidity and has mortality rate of approximately 20% for patients admitted to hospital in the United Kingdom.1 It diagnosed 5-12% adults who present general practitioners with symptoms lower respiratory tract infection,2 3 22-42% are subsequently hospital.3 4 Adherence previous guidelines been poor, this variation practice can lead suboptimal outcomes such as increased longer stay hospital.5 6 7 Hospital (excluding...
Acute upper gastrointestinal bleeding is the commonest medical emergency managed by gastroenterologists in United Kingdom. The most frequently identified source of peptic ulcer disease, but other important causes exist, particularly oesophageal or gastric varices, which are classically associated with more severe bleeding. A large audit UK 20071 indicated that rate mortality from acute (about 7%) has not changed much over past 50 years, and service provision varies considerably across UK....
<h3>Importance</h3> Guidelines recommend against antibiotic use to treat asthma attacks. A study with telithromycin reported benefit, but adverse reactions limit its use. <h3>Objective</h3> To determine whether azithromycin added standard care for attacks in adults results clinical benefit. <h3>Design, Setting, and Participants</h3> The Azithromycin Against Placebo Exacerbations of Asthma (AZALEA) randomized, double-blind, placebo-controlled trial, a United Kingdom–based multicenter...
Although serial peak expiratory flow (PEF) measurements are often used to assess the variability of airflow obstruction, range values be expected in general population has never been defined, nor is there any consensus as how PEF should expressed. We have compared recordings made by 121 subjects selected at random from a small town (Group A) and 221 because wheeze last year B). Subjects were asked record every 2 h during waking hours for 7 days using mini-Wright® meter. Seven Indices derived...
Bone mass has previously been shown to be reduced at peripheral bone sites in patients with bronchial asthma receiving corticosteroids. To assess whether total is body calcium was measured by vivo neutron activation analysis various treatments for and compared results from normal controls rheumatoid arthritis polymyalgia rheumatica. Compared 13.6% (p less than 0.001) daily oral corticosteroids but only 9.0% 0.005) a similar group of who had received supplements the start their corticosteroid...
Inclusion of a standardized measurement airway function is important in epidemiologic studies asthma to facilitate comparison between different studies. Bronchial reactivity widely used such studies, but peak expiratory flow (PEF) variability has number potential advantages. We compared PEF with methacholine challenge tests community population sample. Subjects selected at random (n = 95) and on the basis having experienced wheeze last 12 months 130) performed test maximum dose 12.25 µmol...
To arrive at an agreed, prioritized ranking of treatment uncertainties in asthma that need further research, by developing a collaboration patients, carers and clinicians, facilitated the James Lind Alliance Working Partnership between Asthma UK British Thoracic Society.A four-step procedure: (1) establish collaborative Partnership; (2) identify collect using patient survey analysing existing systematic reviews, clinical guidelines query-answering services; (3) categorize uncertainties; (4)...
This paper explores the complex landscape of evaluating impact digital cultural heritage initiatives within European Union. While present body research has so far addressed various facets culture and heritage, including humanities, a comprehensive understanding projects on broader cultural, social, economic contexts remains critical gap. is particularly important given increasing emphasis demonstrating value securing support for these initiatives. The EU recognizes this strategic importance,...
BACKGROUND--Evidence from laboratory studies suggests that air pollution can produce bronchoconstriction and respiratory symptoms in selected subjects, but the relevance of these findings to exposure natural is unclear. This study was performed determine whether at typical levels found UK has demonstrable effects on function subjects with airways disease. METHODS--Seventy five adult patients diagnoses asthma or chronic obstructive pulmonary disease (COPD) were studied for a period four weeks...
Thereisincreasing interest inclinical guidelines within theUnitedKingdom. Withthis hascomeanincreasing awareness of themethodological issues involved inguideline development, although reports arelimited.' Woolfdescribed threemainmethodsof guideline development: informal consensus, formal andevidence linked.2 In developed through themethodusedmostofteninthe UnitedKingdom,theguideline panelhas poorly defined, oftenimplicit, criteria for decision making. Development by usedby many...
#### The bottom line #### How patients were involved in the creation of this article Patients at every stage creating guideline. Patient groups and individuals contributed to scoping update consultation stage. Lay members active Guideline Development Group, contributing formulation recommendations summarised here, instrumental setting new treatment targets. Having type 1 diabetes reduces life expectancy adults United Kingdom by as much 13 years.1 Despite incontrovertible evidence that...
Measurement of bronchial reactivity is widely used in epidemiological surveys. Histamine has been compared with methacholine inhalation challenge two samples adults from a small town to determine which the better agent for use community studies. Increasing doses histamine and were given, up maximum 4 12 mumol respectively, according method Yan et al, provocative dose agonist causing 20% fall FEV1 (PD20) being measured. More subjects had measurable PD20 than histamine, both random sample 108...
BACKGROUND--Bronchial reactivity measurements are widely used in epidemiological studies to provide an objective marker of asthma. There are, however, several potential advantages measuring peak expiratory flow (PEF) variability instead, particularly large studies. PEF and bronchial were compared a population sample assess the relationships two factors known be associated with airways disease, compare their response rates. METHODS--Subjects aged 18-65 randomly selected from electoral...
Laboratory-based studies have shown that ozone and nitrogen dioxide can potentiate the effect of allergen in sensitized asthmatic subjects, but it is not known whether this interaction important under natural exposure conditions. Thirty-five subjects with clinical diagnoses asthma or chronic obstructive pulmonary disease a provocative dose causing 20% fall forced expiratory volume one second methacholine <12.25 micromol (using Yan method) kept peak flow (PEF) records for 4-week period during...
We present a case of 59 year old asymptomatic lady who was found to have incidental findings pulmonary, osseous and hepatic involvement with sarcoidosis. The lesions were lytic involved unusual sites such as the vertebrae skull base. initial clinical concern had been multiple myeloma or disseminated metastases. Biopsy material obtained following mediastinoscopy revealed chronic, non-necrotising granulomatous lymphadenopathy indicative Cases this could greatly benefit from multidisciplinary...