A5084756778- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Occupational exposure and asthma
- Lung Cancer Diagnosis and Treatment
- Air Quality and Health Impacts
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Occupational Health and Safety Research
- Occupational and environmental lung diseases
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psychosomatic Disorders and Their Treatments
- Orthopedic Surgery and Rehabilitation
- Vascular Tumors and Angiosarcomas
- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Cancer survivorship and care
- Clostridium difficile and Clostridium perfringens research
- Emergency and Acute Care Studies
- Bone and Joint Diseases
- Indoor Air Quality and Microbial Exposure
- Cell Adhesion Molecules Research
- Ultrasound in Clinical Applications
- Mental Health Research Topics
- Microscopic Colitis
- Respiratory Support and Mechanisms
University of Miami
2022-2025
University of Liverpool
2007-2023
University of Virginia
2020-2023
Aintree University Hospitals NHS Foundation Trust
2010-2023
Aintree University Hospital
2006-2018
Caprion (Canada)
2018
Université du Québec à Montréal
2016
St George's, University of London
2012
Imperial College London
2012
North Manchester General Hospital
2012
A joint initiative by the British Thoracic Society and for Cardiothoracic Surgery in Great Britain Ireland was undertaken to update 2001 guidelines selection assessment of patients with lung cancer who can potentially be managed radical treatment.
Primary-care spirometry has been promoted as a method of facilitating accurate diagnosis chronic obstructive pulmonary disease (COPD). The present study examined whether improving rates lead to improvements in pharmacological and nonpharmacological management. From 1999 2003, the current authors provided an open-access reversibility service local primary-care area, which 1,508 subjects were referred. A total 797 (53%) had pre-bronchodilator airflow obstruction (AFO). Of who underwent...
Idiopathic hyperventilation (IH) is a poorly understood condition of sustained hypocapnia and controversial etiology. Although behavioral/emotional factors may contribute, it uncertain whether chemosensitivity altered, maintained during exercise, the associated breathlessness reflects hyperventilation. In 39 patients with IH 23 control subjects, we described ventilatory responses to isocapnic-hypoxia, hyperoxic-hypercapnia, exercise; breath-hold tolerance; breathlessness; psychologic status....
BACKGROUND--Evidence from laboratory studies suggests that air pollution can produce bronchoconstriction and respiratory symptoms in selected subjects, but the relevance of these findings to exposure natural is unclear. This study was performed determine whether at typical levels found UK has demonstrable effects on function subjects with airways disease. METHODS--Seventy five adult patients diagnoses asthma or chronic obstructive pulmonary disease (COPD) were studied for a period four weeks...
There are many approaches to the wrist both volar and dorsal, depending on injury at hand. The design of locking plate has created a rise in distal radius fractures being treated using FCR approach its modifications. It does, however, have limitations visualization ulnar corner radius. In this paper, we will revisit flexor carpi ulnaris pose some considerations for historical context, safety, efficacy, surgical technique.
Exposure to cotton is known produce a specific occupational disease as byssinosis. A large population of textile workers was investigated determine whether such exposure also associated with chronic bronchitis once other possible aetiological factors had been accounted for.A total 2991 were for the presence symptoms compatible bronchitis. An MRC adapted respiratory questionnaire and definition used diagnostic labelling. Current lifetime dust estimated by personal work area sampling, use...
The British Thoracic Society (BTS) Standards of Care (SoC) Committee produced a standard care for occupational asthma (OA) in 2008, based on systematic evidence review performed 2004 by the Occupational Health Research Foundation (BOHRF).BOHRF updated base from 2004-2009 2010.This article summarises changes and is aimed at physicians, nurses other healthcare professionals primary secondary care, health public employers, workers their health, safety representatives.Various recommendations...
Recent studies have implicated a crucial role of Hippo signaling in cell fate determination by biomechanical signals. Here we show that mechanical loading triggers the activation Hippo-PKCζ-NFκB pathway chondrocytes, resulting expression NFκB target genes associated with inflammation and matrix degradation. Mechanistically, activates an atypical PKC, PKCζ, which phosphorylates p65 at Serine 536, stimulating its transcriptional activation. This mechanosensitive PKCζ is impeded cells gene...
Laboratory-based studies have shown that ozone and nitrogen dioxide can potentiate the effect of allergen in sensitized asthmatic subjects, but it is not known whether this interaction important under natural exposure conditions. Thirty-five subjects with clinical diagnoses asthma or chronic obstructive pulmonary disease a provocative dose causing 20% fall forced expiratory volume one second methacholine <12.25 micromol (using Yan method) kept peak flow (PEF) records for 4-week period during...
Idiopathic hyperventilation has been defined as a respiratory-related psychophysiological complaint. This study attempted to clarify relationships between psychological and physiological variables in this condition. Participants demonstrated increased anxiety, depression, symptoms consistent with hyperventilation. was associated reduced peripheral chemosensitivity (isocapnic hypoxic rebreathe; -0.84 +/- 0.5 min-1.%O2(-1)), which normalized experimentally pCO2. Resting CO2 sensitivity close...
Journal Article A STUDY OF THE PERFORMANCE AND COMPARABILITY SAMPLING RESPONSE TO COTTON DUST WORK AREA PERSONAL TECHNIQUES Get access R. MCL. NIVEN, NIVEN * Department of Thoracic and Occupational Medicine, Chest Clinic, Wythenshawe HospitalManchester M23 9LT, U.K. *Author to whom correspondence should be addressed at: Environmental Hospital, Southmoor Road, Wythenshawe, Manchester Search for other works by this author on: Oxford Academic PubMed Google Scholar D. FISHWICK, FISHWICK C. A....
Idiopathic hyperventilation (IH) is a condition of uncertain aetiology characterized by sustained arterial and alveolar hypocapnia plethora symptoms, the most commonly reported being shortness breath, breathlessness. We previously that anxiety increases respiratory frequency minute ventilation with no change in metabolism normal subjects. In this study, we compared breathing response to 5% 7% CO2 gas mixtures subjects (n = 13) IH 9), taking into account breathlessness order determine how...
Informed patient choice is central to modern clinical care but there a paucity of data about how patients respond information regarding complex therapies. This qualitative study aimed understand the attitudes with chronic obstructive pulmonary disease (COPD) toward acute ventilatory support and assess aids decision making ventilation affect patients' views therapy.A standardized five-stage interview process was used explore noninvasive (NIV) invasive mechanical (IMV) in 50 stable COPD...
Knee osteoarthritis (KOA) is a degenerative disease resulting from mechanical overload, where direct physical impacts on chondrocytes play crucial role in development by inducing inflammation and extracellular matrix degradation. However, the signaling cascades that sense these induce pathogenic transcriptional programs of KOA remain to be defined, which hinders identification novel therapeutic approaches. Recent studies have implicated Hippo osteoarthritis. Since senses cues, we aimed...
Aims To investigate the poorly understood relationship between work-related respiratory symptoms, airway reactivity, across working shift change in forced expiratory volume 1 s (FEV1) and changes serial peak flow (sPEF) measures a group of textile workers. Methods Fifty-three workers, 34 exposed to cotton dust 19 man-made fibre (MMF), were investigated using standard questionnaire, sPEF, across-shift FEV1 measurement responsiveness. Results Thirty-four workers (64%) male, 9 (17%) had >5%...
Abstract Purpose of the study To measure number and distribution crackles in patients with idiopathic pulmonary fibrosis (IPF) assess how this relates to measures disease severity. Study design Fourteen IPF had both per litre lung volume function measured every 3 months for 1 year. Crackle counts were expressed according position (upper lower zones) whether they occurred during inspiration expiration. Results At baseline, crackle count unit was higher at bases than apices There a significant...
Functional upper airways obstruction is caused by vocal cord dysfunction and classically occurs in paroxysms closely resembling acute asthmatic attacks. We present two cases which the symptoms signs of demonstrate very little variability with time. suggest that as part this disorder, a syndrome chronic unremitting may occur.