A5080978252- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Antifungal resistance and susceptibility
- HIV-related health complications and treatments
- Bacterial Identification and Susceptibility Testing
- Neonatal and Maternal Infections
- Respiratory Support and Mechanisms
- Family and Patient Care in Intensive Care Units
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Clostridium difficile and Clostridium perfringens research
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Infections and Studies
- COVID-19 Impact on Reproduction
- Bacterial biofilms and quorum sensing
- Healthcare Systems and Technology
- COVID-19 and Mental Health
Hospital La Paz Institute for Health Research
2014-2025
Instituto de Salud Carlos III
2022-2025
Centro de Investigación Biomédica en Red
2022-2025
Hospital Universitario La Paz
2016-2025
Spanish Clinical Research Network
2025
Universidad Carlos III de Madrid
2022
Research Network (United States)
2021
Universidad Autónoma de Madrid
2019-2020
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2020
Hospital General Universitario Gregorio Marañón
2020
Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging problem in the paediatric population worldwide with high mortality rates bloodstream infection (BSI). Objectives To evaluate predictors of 30 day CRE BSI a cohort. Methods A retrospective observational single-centre study (December 2005–August 2018) was conducted. Cases children 0 to 16 years were included. Microbiological identification (MALDI Biotyper) and antimicrobial susceptibility testing (Vitek2®...
ABSTRACT Background and Objectives Bacteria in tracheal aspirate samples from children with tracheostomy can indicate infection or colonization. Our study aimed to determine whether bacterial counts > 10 4 5 CFU (colony forming units)/mL are more frequently associated tracheobronchitis. Additionally, we examine the association between count variables distinguishing colonization tracheobronchitis, along clinical severity indicators. Methods Retrospective cohort of at La Paz University...
To assess the prevalence and risk factors for S. aureus methicillin-resistant (MRSA) nasal colonization in Spanish children.Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data aspirates were collected March to July 2018.A total 1876 enrolled. Prevalence MRSA 33% (95% CI 30.9-35.1) 1.44% 0.9-2), respectively. Thirty-three percent children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors...
The prevalence of multidrug-resistant Gram-negative infections, particularly carbapenem-resistant strains, has become a significant global health concern. Ceftazidime–avibactam (CZA) emerged as promising treatment option. However, data on its efficacy and safety in children are scarce, necessitating further investigation. We conducted descriptive case series at tertiary hospital Spain from February 2019 to January 2022. Pediatric patients (<16 years) treated with CZA for confirmed or...
SARS-CoV-2 virus infects children but, contrary to other respiratory viruses, tend be asymptomatic or have less symptoms than adults and are rarely the index case in household transmission chains. The aim of this study was compare relative viral loads nasopharyngeal samples from aged 0 17 years with those an adult population. We selected 126 positive children. Relative were measured by RT-PCR comparative ∆Ct method using primers probes targeting gene E human RNAseP. significantly lower...
Aim: T2Bacteria® Panel detects six ESKAPE pathogens in around 3.5 h directly whole blood. Our aim was to compare T2Bacteria with simultaneous blood culture critically ill children suspected bloodstream infection. Materials & methods: Retrospective study of admitted our tertiary-care center (2018–2020). Results: A total 60 patients were recruited, including 63 episodes and 75 T2Bacteria/blood cultures performed. Overall agreement between 78.7% a discordance 21.3% (16/75 samples). Conclusion:...
A progressive increase in the incidence of infections caused by multidrug-resistant microorganisms is being reported.Among these resistant microorganisms, main threats are extended-spectrum -lactamase-, AmpC-, and carbapenemase-producing Gram-negative bacilli, methicillin-resistant Staphylococcus aureus vancomycin-resistant Enterococcus faecium.To address this important problem, it essential to establish pediatric Antimicrobial Stewardship programs, perform active epidemiological...
Background: Data on SARS-CoV-2 transmission among children living with healthcare workers (HCWs) are scarce. Methods: A cross-sectional study was performed at a tertiary Hospital in Madrid, including of HCW who suffered from infection between March and May 2020. Children underwent enzyme-linked immunosorbent serological for detecting antibodies: VIRCELL IgG assay. Results: One hundred thirteen 69 HCWs confirmed were recruited: 47 had positive (41.6%). secondary attack rate 43.7% (25% if both...
The prevalence of multidrug-resistant Gram-negative infections, particularly carbapenem-resistant strains, has become a significant global health concern. Ceftazidime-avibactam (CZA) emerged as promising treatment option. However, data on its efficacy and safety in children are scarce, necessitating further investigation. We conducted retrospective study at tertiary hospital Spain from February 2019 to January 2022. Pediatric patients (&lt;16 years) treated with CZA for confirmed or...
Early diagnosis of invasive Candida infections is a challenge for pediatricians, intensivists, and microbiologists. To fill this gap, new nanodiagnostic method has been developed using manual application T2 nuclear magnetic resonance to detect species. The aim study was evaluate, prospectively, the usefulness as tool T2Candida panel in pediatric patients admitted at PICU compared with blood culture.This prospective, observational, unicentric compare results simultaneous cultures candidemia...
A case of 1-year- old male multivisceral transplant recipient with candidemia diagnosed by the T2Candida® test is presented. Optimal management complemented treatment global clinical episode. Duration might be established much more precisely than blood cultures.
Introduction: After the introduction of pneumococcal conjugate vaccines, community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae has decreased whereas Staphylococcus aureus and pyogenes could be increasing. These bacteria have been associated with high rates complications. Aims: (1) To describe characteristics pediatric bacterial CAP requiring hospitalization. (2) compare outcomes according to causative microorganisms. (3) analyze changes in rate etiology over time. Patients...
Introduction Intestinal colonization by Multi-Drug Resistant Organisms (MDROs) can pose a threat on the health of critically ill patients. The extent these organisms is related to previous antibiotic treatments and their ability cause infections among adult aim this study determine relationship between intestinal Relative Loads (RLs) selected resistance genes, consumption extra-intestinal spread pediatric Methods RLs bla CTX-M-1-Family , OXA-1 OXA-48 VIM were determined in 382 rectal swabs...
A progressive increase in the incidence of infections caused by multidrug-resistant microorganisms is being reported. Among these resistant microorganisms, main threats are extended-spectrum β-lactamase-, AmpC-, and carbapenemase-producing Gram-negative bacilli, methicillin-resistant Staphylococcus aureus vancomycin-resistant Enterococcus faecium. To address this important problem, it essential to establish pediatric Antimicrobial Stewardship programs, perform active epidemiological...
An increasing number of women living with perinatally acquired HIV are reaching adulthood and becoming pregnant. Achieving viral suppression is challenging in this population frequently exposed to numerous antiretroviral regimens. This study describes the long-term outcomes pregnant Spain.Descriptive, retrospective, multicenter who gave birth between January 2000 December 2019 Madrid. Epidemiological, clinical, HIV-related data were collected from first delivery end period, including...