A5055535924- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Transplantation: Methods and Outcomes
- Muscle and Compartmental Disorders
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- Pancreatic function and diabetes
- Long-Term Effects of COVID-19
- Erythropoietin and Anemia Treatment
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- Polyomavirus and related diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurological and metabolic disorders
- Parathyroid Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Kidney Stones and Urolithiasis Treatments
- Iron Metabolism and Disorders
- Extracellular vesicles in disease
Fundació Clínic per a la Recerca Biomèdica
2021-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2025
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2023-2024
Hospital Clínic de Barcelona
2018-2024
Red de Investigación en Sida
2024
Universitat de Barcelona
2019-2021
CHU Ambroise Paré
2020
A novel class of membranes, medium cut-off (MCO) has recently been designed to achieve interesting removal capacities for middle and large molecules in hemodialysis (HD) treatments. The few studies published date have reported contradictory results regarding middle-sized when comparing MCO dialyzers versus used online hemodiafiltration (OL-HDF).A prospective, single-center study was carried out 22 patients. Each patient underwent 9 dialysis sessions with routine parameters, one an dialyzer...
Pancreas graft status in simultaneous pancreas-kidney transplant (SPKTx) is currently assessed by nonspecific biochemical markers, typically amylase or lipase. Identifying a noninvasive biomarker with good sensitivity detecting early pancreas rejection could improve SPKTx management.Here, we developed pilot study to explore donor-derived cell-free DNA (dd-cfDNA) performance predicting biopsy-proven acute (P-BPAR) of the cohort 36 recipients biopsy-matched plasma samples. dd-cfDNA was...
The introduction of donor-derived free DNA (ddcfDNA) has emerged as an accurate non-invasive biomarker to diagnose rejection, compared classical ones. Here we evaluate our experience after its implementation in center in-house technique. Single-center cross-sectional study with extraction cell-free blood and quantification the ddcfDNA using AlloSeqcfDNA assay (CareDx) at time performing biopsies 'per protocol' or indication' between December 2020 2023. 172 graft were included (59 for...
Most high-flux dialyzers can be used in both hemodialysis (HD) and online hemodiafiltration (OL-HDF). However, some of these have higher permeability should not prescribed for OL-HDF to avoid high albumin losses. The aim this study was compare the safety efficacy a currently dialyzer HD with those several other which only HD. A prospective, single-center carried out 21 patients. Each patient underwent 5 dialysis sessions routine parameters: 2 Helixone (HD postdilution OL-HDF) 1 session each...
Ischemia-reperfusion injury (IRI) upon transplantation is one of the most impactful events that kidney graft suffers during its life. Its clinical manifestation in recipient, delayed function (DGF), has serious prognostic consequences. However, different definitions DGF are subject to physicians' choices and centers' policies, a more objective tool quantify IRI needed. Here, we propose use donor-derived cell-free DNA (ddcfDNA) for this scope.
In an overwhelming demand scenario, such as the SARS-CoV-2 pandemic, pressure over health systems may outburst their predicted capacity to deal with extreme situations. Therefore, in order successfully face a emergency, scientific evidence and validated models are needed provide real-time information that could be applied by any center, especially for high-risk populations, transplant recipients. We have developed hybrid prediction model whose accuracy relative several alternative...
Improvement in insulin alternatives is leading to a delayed presentation of microvascular and macrovascular complications diabetes. The objective this study was evaluate the long-term outcomes older (≥50 years) diabetic patients who receive pancreas transplantation (PT).We retrospectively evaluated all 338 PTs performed at our center between 2000 2016 (mean follow-up 9.4±4.9 years). Recipient graft survivals were estimated for up 10 years after PT. Major adverse cardiovascular events (MACEs)...
Abstract Background Monoclonal serum free light chains (sFLC) are a well-known cause of renal impairment (RI) in patients with multiple myeloma (MM). As an indicator monoclonality, sFLC ratio has acquired key role the diagnosis and monitorization disease. However, its interpretation is altered chronic kidney disease (CKD). This study aims to evaluate modification reference range CKD, propose optimal for CKD. Methods Serum FLC κ/λ estimated glomerular filtration rate (eGFR) were...
The transplant community is focused on prolonging the ex vivo preservation time of kidney grafts to allow for long-distance graft transportation, assess viability marginal grafts, and optimize a platform translation innovative therapeutics clinical practice, especially those cell vector delivery organ conditioning reprogramming. We describe first case feasible from donor after uncontrolled circulatory death over 73-h period using normothermic perfusion analyze hemodynamic, biochemical,...
Abstract Blood flow (Qb) is one of the dialysis parameters most strongly influencing performance modalities. However, few studies have compared different modalities in patients with low Qb. We conducted a prospective, single‐center study 21 patients. Each patient underwent four sessions routine parameters: high‐flux hemodialysis (HD), predilution hemodiafiltration (pre‐HDF), expanded HD (HDx), and postdilution HDF (post‐HDF). The removal ratios (RR) urea, creatinine, ß 2 ‐microglobulin,...
<b><i>Introduction:</i></b> COVID-19 is a highly contagious disease that has easily spread worldwide. Outpatient maintenance hemodialysis seems to entail an increased risk of contagion, and previous reports inform mortality among this population. <b><i>Methods:</i></b> We retrospectively analyzed clinical laboratory parameters, outcomes, management once discharged CKD-5D patients infected with SARS-CoV-2 from our health area....
Metabolic acidosis is a common problem in haemodialysis patients, but overcorrection has been associated with higher mortality. There no clear definition of the optimal serum bicarbonate target or dialysate bicarbonate. This study analysed impact reducing from 35 to 32 mEq/L on plasma levels cohort patients treated online haemodiafiltration (OL-HDF).We performed prospective stable chronic OL-HDF programme for at least 12 months Hospital Clinic Barcelona. We pre- and post-dialysis total...
Current literature suggests a higher risk of pregnancy-related complications in patients with renal fibromuscular dysplasia (FMD). The aim our study was to assess the nature and prevalence subsequently diagnosed FMD. A call for participation sent centers contributing European/International FMD Registry. Patients at least 1 pregnancy were included. Data on collected through medical files characteristics from 534 pregnancies obtained 237 patients. Despite fact that, 96% cases, not before...
Obesity increases the risk of developing chronic kidney disease (CKD), which has a major negative impact on global health. Bariatric surgery (BS) demonstrated substantial improvement obesity-related comorbidities and thus, it emerged as potential therapeutic tool in order to prevent end-stage renal disease. A limited number publications date have examined beneficial effects risks BS patients with non-advanced stages CKD. We aimed investigate safety CKD 3–4 (directly related or not obesity)...
<b><i>Background:</i></b> Etelcalcetide is a novel second-generation calcimimetic that, because of its intravenous administration, could improve treatment adherence in secondary hyperparathyroidism (SHPT). The aim this study was to evaluate the effectiveness etelcalcetide compared with that cinacalcet controlling SHPT patients under hemodialysis. <b><i>Methods:</i></b> A prospective observational performed 29 hemodialysis who switched from...
Tacrolimus is pivotal in pancreas transplants but poses challenges maintaining optimal levels due to recipient differences. This study aimed explore the utility of time spent below therapeutic range and intrapatient variability predicting rejection