A5090335286- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- Education and Teacher Training
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Biomarkers in Disease Mechanisms
- Click Chemistry and Applications
- Hemoglobinopathies and Related Disorders
- Liver Disease Diagnosis and Treatment
- Cell death mechanisms and regulation
- Orthopedic Infections and Treatments
- Burn Injury Management and Outcomes
- Social Sciences and Policies
- Neutropenia and Cancer Infections
- Dialysis and Renal Disease Management
- Gestational Trophoblastic Disease Studies
- Angiogenesis and VEGF in Cancer
- Education in Rural Contexts
- Autopsy Techniques and Outcomes
- Antibiotic Use and Resistance
- Cancer-related gene regulation
Leitat Technological Center
2010-2025
Universidad Nacional Experimental Rafael María Baralt
2023
Acciona (Spain)
2023
Ação Educativa
2023
Pemex (Mexico)
2018-2021
Fundación Valle del Lili
2018
New York University Press
2015
Hospital General de México
2011
Universidad de Granada
2006
Instituto de Investigación Biosanitaria de Granada
2006
S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis stimulating angiogenesis. We demonstrated that S100A4 synergizes with vascular endothelial growth factor (VEGF), via RAGE receptor, in promoting cell migration increasing KDR expression MMP-9 activity. In vivo overexpression led to significant increase vascularization human melanoma xenograft M21 model. Conversely, when silencing shRNA technology, dramatic decrease...
Despite progresses in diagnosis and treatment, pancreatic cancer continues to have the worst prognosis of all solid malignant tumors. Recent evidences suggest that metastasis-promoting protein S100P stimulates tumor proliferation, survival, invasion metastasis progression through extracellular functions. Moreover, its expression is strongly correlated with poor patients several types although entire molecular mechanism responsible for diverse biological functions not fully understood. We...
Health-related quality of life (HRQoL) patients with X-linked hypophosphatemia (XLH) is lower than that both the general population and other chronic diseases, mainly due to diagnostic delay, treatment difficulties, poor psychosocial support, problems social integration. Early diagnosis optimal are paramount control disease in XLH, avoid complications, maintain or improve their HRQoL. We, therefore, analyzed HRQoL pediatric adult XLH treated conventional therapy Spain.We used several...
Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance conventional therapies, leading poor patient outcomes. This challenges the efficiency photodynamic therapy (PDT), which relies on generation cytotoxic reactive oxygen species (ROS) through irradiation photosensitizer (PS), process partially dependent levels. In this work, we introduce novel family potent PSs based ruthenium(II) polypyridyl complexes with 2,2′-bipyridyl ligands...
Abstract Background Methotrexate is a chemotherapeutic drug that used in therapy of wide variety cancers. The efficiency treatment with this compromised by the appearance resistance. Combination treatments MTX other drugs could modulate expression genes involved resistance would be an adequate strategy to prevent development Methods differential pattern between sensitive and MTX-resistant cells was determined whole human genome microarrays analyzed GeneSpring GX software package. A global...
The members of the human regulators calcineurin (RCAN) protein family are endogenous (CN)-cytosolic nuclear factor activated T-cells (NFATc) pathway activation. This function is explained by presence a highly conserved calcipressin inhibitor (CIC) motif in RCAN proteins, which has been shown to compete with NFATc for binding CN and therefore able inhibit dephosphorylation activation CN. Very recently, emerging roles proteins transformation, tumor angiogenesis metastasis have described...
Abstract A novel conjugate between a cyclometalated platinum(II) complex with dual antiangiogenic and antitumor activity cyclic peptide containing the RGD sequence (‐Arg‐Gly‐Asp‐) has been synthesized by combining solid‐ solution‐phase methodologies. Although conjugation rendered non‐cytotoxic compound in all tested tumor cell lines (± α V β 3 5 integrin receptors), of Pt‐c(RGDfK) human umbilical vein endothelial cells at sub‐cytotoxic concentrations opens way to design class angiogenesis...
Antibody-Drug Conjugates (ADCs) have been shown to produce clinical benefit in cancer patient thanks their ability target highly cytotoxic small molecules tumor cells. However, the development of these complex faces significant challenges due need combine a large biologic drug with molecule generate desired bioconjugate. We describe here use protein ligation methodology, based on native chemical reaction site-specific Conjugates, which does not require incorporation unnatural modifications...
We analyzed the differential gene expression in pancreatic cancer cell line NP-18 upon induction of apoptosis caused by cyclin-dependent kinase inhibition triggered either overexpression tumor suppressor <i>p16<sup>INK4A</sup></i>using an adenoviral construction or incubation with chemical inhibitors, roscovitine olomoucine. Screening was performed using cDNA arrays from Clontech that allowed determination 1,176 genes specifically related cancer. The analysis carried...
IntroductionDiagnosis of Minimal hepatic encephalopathy (MHE) requires psychometric tests, although new methods are needed since sensitivity, specificity, and accuracy low.The P300 event-related potential (ERP) is obtained by auditory visual stimuli, only the has been used to detect MHE.We aimed compare diagnostic features MHE. Materials Sixty patients with liver cirrhosis thirty-five healthy controls completed thePsychometric Hepatic Encephalopathy Score (PHES), critical flicker frequency...
The Ca2+/calmodulin-mediated phosphatase activity of calcineurin (CN) integrates calcium-mediated signaling with gene expression programs involved in the control essential cellular processes health and disease, such as immune response pathogenesis cancer progression metastasis. In addition, CN is target immunosuppressive drugs cyclosporine A (CsA) FK-506 which are cornerstone immunosuppressant therapy. Unfortunately, long-term administration these results severe side effects. Herein, we...
The aim of the study was to establish an association between viroimmunological status HIV positive patients and their levels 70-kD heat shock protein (Hsp70). longitudinal retrospective case involved 61 at University Hospital in Granada (Spain) from 1999 2002. Twenty-five were viroimmunologically stable, while other 36 had suffered virological failure. A minimum three blood samples taken intervals least 3 months for who stable virologically immunologically, whereas four failure group: two...
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The purpose of this essay is to carry out an analysis the importance critical thinking from position transformative action university teachers, who must encourage active and reflective participation. Using a descriptive methodology with documentary bibliographic design through review some authors Garcia Reyes y Pachano (2012) Madueño (2014), Freire P (2014) Solbes J. (2017) Zambrano S. (2015) make important contributions, For this, it sought that in educational practices teacher thought...