A5059695533- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Lanthanide and Transition Metal Complexes
- HIV/AIDS drug development and treatment
Universitat de Barcelona
2022-2025
Institut de Biomedicina de la Universitat de Barcelona
2022-2025
Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance conventional therapies, leading poor patient outcomes. This challenges the efficiency photodynamic therapy (PDT), which relies on generation cytotoxic reactive oxygen species (ROS) through irradiation photosensitizer (PS), process partially dependent levels. In this work, we introduce novel family potent PSs based ruthenium(II) polypyridyl complexes with 2,2′-bipyridyl ligands...
Human immunodeficiency virus-type 1 (HIV-1) remains one of the leading contributors to global burden disease, and novel antiretroviral agents with alternative mechanisms are needed cure this infection. Here, we describe an exploratory attempt optimize properties benfluron, a cytostatic agent previously reported exhibit strong anti-HIV activity likely based on inhibitory actions virus transcription Rev-mediated viral RNA export. After obtaining six analogs designed modify benzo[c]fluorenone...
Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation the bloodstream, is one main hallmarks nanomedicine, especially that NIR fluorescent probes cancer theragnosis. The herein reported technology furnishes water-dispersible double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG-NCs), using a versatile and highly efficient one-pot industrially...