A5029780592- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Inflammatory Bowel Disease
- Graphene and Nanomaterials Applications
- Pneumonia and Respiratory Infections
- Diabetes and associated disorders
- Vitamin C and Antioxidants Research
- Gut microbiota and health
- Reproductive System and Pregnancy
- Nanoparticle-Based Drug Delivery
- COVID-19 Impact on Reproduction
- Salivary Gland Disorders and Functions
- Diet and metabolism studies
- Intestinal and Peritoneal Adhesions
- Clostridium difficile and Clostridium perfringens research
- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2017-2024
Primary Sjögren's syndrome (pSS) is an autoimmune disease triggered by a combination of environmental and host genetic factors, which results in the focal lymphocytic infiltration exocrine glands causing eye mouth dryness. Glandular infiltrates include T B cell subsets positive for CD5 and/or CD6, two surface scavenger receptors involved fine-tuning intracellular signals mediated antigen-specific receptor complex (TCR) (BCR) cells. Moreover, epithelial cells inflamed overexpress CD166/ALCAM,...
Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) resulting from the interaction of multiple environmental, genetic immunological factors. CD5 CD6 paralogs encoding lymphocyte co-receptors involved in fine-tuning intracellular signals delivered upon antigen-specific recognition, microbial pattern recognition cell adhesion. While expression variation is known to influence some immune-mediated disorders, their role IBD remains unclear. To this end, Cd5-...
Background CD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at center of immunological synapse. There, assists in cell-to-cell contact stabilization and modulation activation/differentiation events through interaction CD166/ALCAM (activated leukocyte cell adhesion molecule), its main reported ligand. While accumulating evidence attracting new interest on targeting for therapeutic purposes autoimmune disorders, little known potential...
Several genetic polymorphisms of the innate immune system have been described to increase risk cytomegalovirus (CMV) infection in transplant patients. The aim this study was assess impact a polygenic score predict CMV and disease high recipients (heart, liver, kidney or pancreas). On hundred sixteen CMV-seronegative grafts from CMV-seropositive donors undergoing heart, pancreas transplantation 7 centres were prospectively included for purpose during 2-year period. All received 100-day...
Modulation of antitumor immune responses by targeting checkpoint regulators has been proven successful in the treatment many different tumors. Recent evidence shows that lymphocyte receptor CD5 -a negative regulator TCR-mediated signaling- may play a role anti-tumor response. To explore such an issue, we developed transgenic C57BL/6 mice expressing soluble form human (shCD5EμTg), putatively blocking CD5-mediated interactions ("decoy receptor" effect). Homozygous shCD5EμTg showed reduced...
Sepsis is an unmet clinical need constituting one of the most important causes death worldwide, a fact aggravated by appearance multidrug resistant strains due to indiscriminate use antibiotics. Host innate immune receptors involved in pathogen-associated molecular patterns (PAMPs) recognition represent source broad-spectrum therapies alternative or adjunctive Among few members ancient and highly conserved scavenger receptor cysteine-rich superfamily (SRCR-SF) sharing bacterial-binding...
CD6 is a lymphocyte-specific scavenger receptor expressed on adaptive (T) and innate (B1a, NK) immune cells, which involved in both fine-tuning of lymphocyte activation/differentiation recognition bacterial-associated molecular patterns (i.e., lipopolysaccharide). However, evidence CD6's role the physiological response to bacterial infection was missing. Our results show that induction monobacterial polymicrobial sepsis Cd6-/- mice lower survival rates increased loads pro-inflammatory...
Invasive fungal diseases represent an unmet clinical need that could benefit from novel immunotherapeutic approaches. Host pattern recognition receptors (e.g., Toll-like receptors, C-type lectins, or scavenger receptors) sense conserved cell wall constituents may provide suitable antifungal agents. Thus, we explored the therapeutic potential of lymphocyte class I receptor CD5, a nonredundant component host immune response binds to β-glucans. Antifungal properties soluble ectodomain human CD5...
Abstract Background The view of prostate cancer (PCa) progression as a result the interaction epithelial cells with host's immune system is supported by presence tumor infiltrating lymphocytes (TILs). TILs fate and microenvironment mediated accessory molecules such CD5 CD6, two signal‐transducing coreceptors involved in fine‐tuning T cell responses. While nature ligand still controversial, CD6 binds CD166/ALCAM, adhesion molecule dissemination cancers, including PCa. purpose present study...
Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation the bloodstream, is one main hallmarks nanomedicine, especially that NIR fluorescent probes cancer theragnosis. The herein reported technology furnishes water-dispersible double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG-NCs), using a versatile and highly efficient one-pot industrially...