A5012725188- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Antifungal resistance and susceptibility
- Immunotherapy and Immune Responses
- Fungal Infections and Studies
- Immune Response and Inflammation
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2020
The CD6 glycoprotein is a lymphocyte surface receptor putatively involved in T cell development and activation. facilitates adhesion between cells antigen-presenting through its interaction with CD166/ALCAM (activated leukocyte molecule), physically associates the (TCR) at center of immunological synapse. However, precise role during thymocyte peripheral immune responses remains to be defined. Here, we analyze vivo consequences deficiency. CD6−/− thymi showed reduction both CD4+ CD8+...
Individual susceptibility differences to fungal infection following invasive and/or immunosuppressive medical interventions are an important clinical issue. In order explore immune response-related factors that may be linked susceptibility, we have compared the response of inbred C57BL/6J and outbred CD1 mouse strains different experimental models sepsis. The challenge animals with zymosan-induced generalised inflammation model revealed poorer survival rates in C57BL/6J, consistent lower Th1...
Background CD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at center of immunological synapse. There, assists in cell-to-cell contact stabilization and modulation activation/differentiation events through interaction CD166/ALCAM (activated leukocyte cell adhesion molecule), its main reported ligand. While accumulating evidence attracting new interest on targeting for therapeutic purposes autoimmune disorders, little known potential...